{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:28:28Z","timestamp":1786321708108,"version":"build-2736575974"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20522"],"award-info":[{"award-number":["U22A20522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32311530695"],"award-info":[{"award-number":["32311530695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The immune system initially protects hosts against viral pathogens, with chemokines guiding immune cell movement. However, their expression patterns and immune cell recruitment mechanisms during transmissible gastroenteritis virus (TGEV) infection are still not fully understood. Here, we identified a distinct chemokine expression profile in intestinal epithelial cells following TGEV infection. Among these, CXCL10 selectively induced the chemotaxis of CD4+ CXCR3+ T cells, while only modestly recruiting CD8+ CXCR3+ (Tc1) T cells and showing minimal involvement in B cell recruitment, thereby shaping the intestinal immune microenvironment to promote TGEV infection. CXCL10 can also upregulate the expression of its receptor CXCR3, thereby further potentiating the migration of CD4+ T cells to the infected region. During this process, CXCL10 activated the CXCR3-Rho GTPase-cofilin signaling axis, driving actin cytoskeletal remodeling. Through this process, CD4+ T cells are channeled from the lamina propria to the infected intestinal lining, facilitating their functional responses. Collectively, these findings reveal a novel mechanism underlying Th1 cell trafficking during TGEV infection and suggest objectives for therapeutic vaccine creation and disease management.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag222","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T23:38:58Z","timestamp":1786318738000},"source":"Crossref","is-referenced-by-count":0,"title":["The CXCL10\/CXCR3 axis drives actin remodeling to recruit CD4+ T cells to gut epithelium during transmissible gastroenteritis virus infection"],"prefix":"10.1093","volume":"215","author":[{"given":"Chen","family":"Tan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Lanzhou,","place":["China"]},{"name":"Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Li\u00e8ge , Li\u00e8ge,","place":["Belgium"]},{"name":"Hainan Key Laboratory of Tropical Animal Breeding and Infectious Disease Research, Institute of Animal Husbandry and Veterinary Medicine, Hainan Academy of Agricultural Sciences , Haikou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Lanzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Lanzhou,","place":["China"]},{"name":"Hainan Key Laboratory of Tropical Animal Breeding and Infectious Disease Research, Institute of Animal Husbandry and Veterinary Medicine, Hainan Academy of Agricultural Sciences , Haikou,","place":["China"]},{"name":"Nutritional Biology, Wageningen University and Research , Wageningen, the","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Lanzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Breeding and Infectious Disease Research, Institute of Animal Husbandry and Veterinary Medicine, Hainan Academy of Agricultural Sciences , Haikou,","place":["China"]},{"name":"College of Veterinary Medicine, Gansu Agricultural University , Lanzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangfeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Hainan Key Laboratory of Tropical Animal Breeding and Infectious Disease Research, Institute of Animal Husbandry and Veterinary Medicine, Hainan Academy of Agricultural Sciences , Haikou,","place":["China"]},{"name":"College of Veterinary Medicine, Xinjiang Agricultural University , Urumqi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangliang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Lanzhou,","place":["China"]},{"name":"Hainan Key Laboratory of Tropical Animal Breeding and Infectious Disease Research, Institute of Animal Husbandry and Veterinary Medicine, Hainan Academy of Agricultural Sciences , Haikou,","place":["China"]},{"name":"College of Veterinary Medicine, Gansu Agricultural University , Lanzhou,","place":["China"]},{"name":"College of Veterinary Medicine, Xinjiang Agricultural University , Urumqi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"2026080919373696900_vkag222-B1","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1021\/acs.jmedchem.6b01309","article-title":"Structural analysis of chemokine receptor\u2013ligand interactions","volume":"60","author":"Arimont","year":"2017","journal-title":"J Med Chem"},{"key":"2026080919373696900_vkag222-B2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/ijms18020342","article-title":"Mechanisms of regulation of the chemokine-receptor 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