{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:10:42Z","timestamp":1788793842570,"version":"build-2803163510"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH Public Access Policy"},{"name":"PubMed Central upon the Official Date of Publication"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-AR071369"],"award-info":[{"award-number":["R01-AR071369"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32-AI074490"],"award-info":[{"award-number":["T32-AI074490"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["F30-AI186235"],"award-info":[{"award-number":["F30-AI186235"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-AI147383"],"award-info":[{"award-number":["R01-AI147383"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the University of Pittsburgh"},{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Idiopathic inflammatory myopathy (IIM) is a systemic autoimmune disease targeting muscle and extramuscular organs, but the molecular mechanisms driving IIM pathogenesis remain largely undefined. Muscle fibroblasts are central to orchestrating inflammation in myositis. Here, we investigated muscle fibroblast dynamics using a single-cell RNA sequencing approach in an established murine model of anti-histidyl\u2013tRNA synthetase (HRS, also known as Jo-1)-induced myositis. In fibroblasts, there was a robust activation of an IL-17 gene signature during disease. Among the induced genes was Nfkbiz, which encodes I\u03baB\u03b6, a noncanonical NF-\u03baB transcriptional coactivator known to be key for pathologic IL-17 signaling in a variety of autoimmune settings. In muscle fibroblasts, I\u03baB\u03b6 was potently activated by IL-17 in vitro and was essential for IL-17 signaling responsiveness. Surprisingly, however, the IL-17\u2013I\u03baB\u03b6 signaling axis was dispensable for the histopathological phenotype in HRS-induced myositis. Thus, despite a prominent IL-17 transcriptional signature, IL-17 and I\u03baB\u03b6 are not required for autoantibody production or tissue inflammation in this model system.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag225","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:51:38Z","timestamp":1785937898000},"source":"Crossref","is-referenced-by-count":0,"title":["IL-17\u2013driven transcriptional programs in muscle fibroblasts are not required for pathogenesis in murine anti-histidyl-tRNA synthetase (Jo-1) myositis"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0121-2691","authenticated-orcid":false,"given":"Decheng","family":"Li","sequence":"first","affiliation":[{"name":"Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA,","place":["United States"]},{"name":"Tsinghua Medicine, Tsinghua University , Beijing,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P","family":"Reay","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shachi P","family":"Vyas","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9424-1993","authenticated-orcid":false,"given":"Kenta","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana P","family":"Ascherman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Gaffen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh , Pittsburgh, PA,","place":["United 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pathogenesis of myositis","volume":"4","author":"Suber","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"key":"2026090710442115300_vkag225-B4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrneurol.2011.63","article-title":"Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis","volume":"7","author":"Mammen","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"2026090710442115300_vkag225-B5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s11926-996-0025-3","article-title":"Myositis specific autoantibodies","volume":"8","author":"Targoff","year":"2006","journal-title":"Curr Rheumatol Rep"},{"key":"2026090710442115300_vkag225-B6","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.4049\/jimmunol.1203070","article-title":"Functional redundancy of MyD88-dependent signaling pathways in a murine model of histidyl-transfer RNA synthetase-induced myositis","volume":"191","author":"Fernandez","year":"2013","journal-title":"J 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