{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:31:55Z","timestamp":1786383115401,"version":"build-2736575974"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD2400804"],"award-info":[{"award-number":["2022YFD2400804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Natural Science Foundation of Shanghai","award":["24ZR1419700"],"award-info":[{"award-number":["24ZR1419700"]}]},{"name":"the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation","award":["GZB20250722"],"award-info":[{"award-number":["GZB20250722"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>B-cell responses rely on a tightly coordinated interplay between transcriptional programs and metabolic reprogramming. Upon activation, B cells remodel their metabolic profiles, with enhanced glutamine metabolism supporting biomass synthesis and proliferation. However, whether and how glutaminolysis underpins B-cell responses in early vertebrates remains largely unexplored. Here, using the Nile tilapia (Oreochromis niloticus) as a model, we demonstrate that IgM+ B cells markedly increase glutamine utilization upon activation. Glutamine deprivation impaired B-cell activation and proliferation, whereas glutamine supplementation promoted these processes. During Edwardsiella piscicida infection, pharmacological inhibition of glutamine metabolism significantly reduced the expansion of IgM+ B cells and compromised antibody secretion. Mechanistically, glutamine metabolism in tilapia IgM+ B cells was governed by the transcription factor c-Myc. Inhibition of c-Myc disrupted glutaminolysis, leading to diminished B-cell proliferation and antibody production. Upon activation, IgM+ B cells coordinated c-Myc expression and downstream glutamine metabolism through the mTORC1 and ERK signaling pathways, thereby coordinating metabolic and immune functions. Notably, this regulatory mechanism operated in a B cell\u2013intrinsic manner and was independent of T-cell help. Collectively, our findings reveal that teleost B cells possess evolutionarily conserved and sophisticated immunometabolic regulatory programs. This study provides new insights into how metabolic pathways are integrated with immune signaling to control B-cell function, highlighting coordinated immunometabolic regulation as a fundamental mechanism underlying vertebrate B-cell immunity.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag227","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:13:38Z","timestamp":1786382018000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts"],"prefix":"10.1093","volume":"215","author":[{"given":"Xinying","family":"Jiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Geng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokai","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University , 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