{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:05:29Z","timestamp":1789682729517,"version":"4.0.1"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"publisher","award":["R01-DE033643"],"award-info":[{"award-number":["R01-DE033643"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2025ZNSFSC0763"],"award-info":[{"award-number":["2025ZNSFSC0763"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB-TRR 369"],"award-info":[{"award-number":["SFB-TRR 369"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clonal hematopoiesis of indeterminate potential (CHIP) arises from age-related somatic mutations in hematopoietic stem cells in the bone marrow (BM), driving clonal expansion and altered phenotypes. Loss-of-function mutations in the epigenetic regulator TET2 are among the most frequent in CHIP and increase the risk of hematologic malignancies and chronic inflammatory disorders. Here, we investigated the impact of TET2-driven CHIP on inflammatory bone loss. Partial BM reconstitution with TET2-deficient (Tet2\u2013\/\u2013) cells promoted clonal expansion and spontaneous periodontitis, characterized by gingival inflammation and alveolar bone loss. Furthermore, mice with TET2-driven CHIP exhibited heightened susceptibility to experimentally induced bone loss, including ligature-induced periodontitis and collagen antibody-induced arthritis. This inflammatory bone loss phenotype was associated with increased tissue infiltration of hyperinflammatory Tet2\u2013\/\u2013 neutrophils and monocytes, elevated IL-17\u2013producing CD4\u207a T cells (Th17), and enhanced osteoclastogenesis driven by paracrine signals from Tet2\u2013\/\u2013 myeloid cells acting on wild-type osteoclast precursors. Although T cell\u2013intrinsic TET2 deficiency minimally affected Th17 differentiation in vitro, Tet2\u2013\/\u2013 dendritic cells exhibited enhanced capacity to drive Th17 differentiation from wild-type CD4\u207a T cells. These findings reveal mechanistic links between TET2-driven CHIP and the pathogenesis of inflammatory bone loss disorders.<\/jats:p>","DOI":"10.1093\/jimmun\/vkag248","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:29:16Z","timestamp":1789680556000},"source":"Crossref","is-referenced-by-count":0,"title":["Exacerbation of inflammatory bone loss in TET2-driven clonal hematopoiesis"],"prefix":"10.1093","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-7357","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan,","place":["China"]},{"name":"Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Barovic","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry and Laboratory Medicine, University Hospital, Technische Universit\u00e4t Dresden , Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center , Houston, TX,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan,","place":["China"]},{"name":"Center of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7142-2386","authenticated-orcid":false,"given":"Xiaofei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania , Philadelphia, PA,","place":["United States"]},{"name":"School of Life Sciences and Biotechnology, Sheng Yushou Center of Cell Biology and Immunology, Shanghai Jiao Tong University , Shanghai,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hyung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania , Philadelphia, PA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-9802","authenticated-orcid":false,"given":"Peter J","family":"Murray","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute of Biochemistry , Martinsried,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Kalafati","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry and Laboratory Medicine, University Hospital, Technische Universit\u00e4t Dresden , Dresden,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Chronopoulos","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry and Laboratory Medicine, University Hospital, Technische Universit\u00e4t 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