{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:24Z","timestamp":1792785984765,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Higher Education of Cameroon","award":["26\/048\/MINESUP\/SG\/CS\/CEA2"],"award-info":[{"award-number":["26\/048\/MINESUP\/SG\/CS\/CEA2"]}],"id":[{"id":"https:\/\/ror.org\/02xvp8z16","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Science and Technology of China through the Talented Young Scientist Program","award":["Cameroon-25-001"],"award-info":[{"award-number":["Cameroon-25-001"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The cowpea weevil, Callosobruchus maculatus (Fabricius) (Coleoptera: Bruchidae), is a major stored-product pest. Resistance to synthetic insecticides such as dichlorvos (DDVP) has prompted interest in alternatives with distinct modes of action. This study compared multigenerational transcriptional responses of C. maculatus to DDVP and the botanical insecticide Lippia adoensis (Hochst. ex Walp.) (Lamiales: Verbenaceae) essential oil (EO). DDVP exposure was associated with progressive fitness recovery across generations, together with upregulated expression of detoxification-related genes (e.g. Cyp6g1-2, Cyp6g1-3, Gst, Est2, Pod) and cholesterol metabolism-related genes (e.g. Dhcr24-1, Dhcr24-3). In contrast, L. adoensis EO was associated with consistently higher mortality and did not elicit comparable transcriptional changes in these gene sets. Clustering patterns placed EO-treated populations closer to controls, with less evidence of the DDVP-associated expression pattern. An antagonistic index comparing treatment-related fold changes indicated an opposing transcriptional relationship between EO and DDVP. Overall, the findings are consistent with L. adoensis EO acting without inducing the DDVP-associated detoxification expression pattern, suggesting a distinct transcriptional profile that may inform botanical-based approaches to pest management.<\/jats:p>","DOI":"10.1093\/jisesa\/ieag107","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:13:54Z","timestamp":1790334834000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring the multigenerational effects of\n                    <i>Lippia adoensis<\/i>\n                    (Lamiales: Verbenaceae) essential oil and Dichlorvos on\n                    <i>Callosobruchus maculatus<\/i>\n                    (Coleoptera: Bruchidae) life-history traits and gene expression"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2162-2119","authenticated-orcid":false,"given":"Mazarin","family":"Akami","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24, 157, Douala,","place":["Cameroon"]},{"name":"Xianghu Laboratory , Hangzhou, 311231,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-0223","authenticated-orcid":false,"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Xianghu Laboratory , Hangzhou, 311231,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4387-7693","authenticated-orcid":false,"given":"Bingbing","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Plant Science & Technology, Huazhong Agricultural University , No. 1 Shizishan Street, Wuhan 430070,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6991-8088","authenticated-orcid":false,"given":"Ousman","family":"Tamgue","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24, 157, Douala,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cabrel","family":"Bafong Ngueya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24, 157, Douala,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Pocssie Samenoug","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24, 157, Douala,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francioli","family":"Koro Koro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24, 157, Douala,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-0366","authenticated-orcid":false,"given":"Rosalie Annie","family":"Ngono Ngane","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24, 157, Douala,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8949-7150","authenticated-orcid":false,"given":"Nicolas","family":"Njintang Yanou","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Ngaoundere , Ngaoundere,","place":["Cameroon"]},{"name":"Department of Food Science and Nutrition, National School of Agro-Industrial Sciences, University of Ngaoundere , Ngaoundere,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias Nchiwan","family":"Nukenine","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Ngaoundere , Ngaoundere,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6434-5604","authenticated-orcid":false,"given":"Baolei","family":"Jia","sequence":"additional","affiliation":[{"name":"Xianghu Laboratory , Hangzhou, 311231,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4086-2556","authenticated-orcid":false,"given":"Yanlai","family":"Yao","sequence":"additional","affiliation":[{"name":"Xianghu Laboratory , Hangzhou, 311231,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-1422","authenticated-orcid":false,"given":"Chang-Ying","family":"Niu","sequence":"additional","affiliation":[{"name":"College of Plant Science & Technology, Huazhong Agricultural University , No. 1 Shizishan Street, Wuhan 430070,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026092923004280400_ieag107-B1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S1006-8104(17)30002-8","article-title":"Chemical composition and bioactivity of Lippia adoensis Hochst ex. 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