{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:44:49Z","timestamp":1793025889198,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"PhytoHealth Corporation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cancer-related fatigue (CRF) is an emerging clinical issue, although its prevalence and impact on quality of life (QOL) in cancer patients in Taiwan remain unclear. The present nationwide cross-sectional study was conducted to provide a thorough overview of the prevalence, related factors and impact of CRF in Taiwan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this multi-center survey, data were collected using the International Classification of Diseases 10th Revision (ICD-10) Fatigue evaluation, Brief Fatigue Inventory\u2013Taiwan (BFI-T), the Chinese version of the Symptom Distressed Scale and a fatigue experience survey. Logistic regression was used to determine the correlations between fatigue characteristics and the factors studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1207 cancer patients were recruited from 23 hospitals in Taiwan. Fatigue was the most distressing symptom in Taiwanese cancer patients. The distress score was higher if CRF was diagnosed using ICD-10 compared with BFI-T. Rest and nutritional supplementation were the most common non-pharmacological treatments; blood transfusion was the most common pharmacological treatment. There were 45% of patients reported not receiving a timely intervention for fatigue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Fatigue is the most bothersome symptom reported by Taiwanese cancer patients. Caregivers should be aware of the impact of CRF on QOL in cancer patients, constantly measure the severity of fatigue and provide appropriate interventions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyaa038","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T12:25:21Z","timestamp":1583497521000},"page":"693-700","source":"Crossref","is-referenced-by-count":27,"title":["A nationwide survey of fatigue in cancer patients in Taiwan: an unmet need"],"prefix":"10.1093","volume":"50","author":[{"given":"Kun-Ming","family":"Rau","sequence":"first","affiliation":[{"name":"Department of Hematology-Oncology, E-Da Cancer Hospital, Kaohsiung, Taiwan"},{"name":"I-Shou University, Collage of Medicine, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiow-Ching","family":"Shun","sequence":"first","affiliation":[{"name":"School of Nursing, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzeon-Jye","family":"Chiou","sequence":"first","affiliation":[{"name":"Cancer Center, Taipei Municipal Wanfang Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hsien","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan"},{"name":"Chang Gung University, College of Medicine, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hsu","family":"Ko","sequence":"first","affiliation":[{"name":"Anfa Clinic, Taipei, Taiwan"},{"name":"Division of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yang","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Tsung","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Chi-Mei Medical Center, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Huei","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Shyong","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan"},{"name":"Division of Hematology-Oncology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruey-Kuen","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, MacKay Memorial Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,18]]},"reference":[{"key":"2020061005543759800_ref1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/1472-6963-9-190","article-title":"Distribution and determinants of patient satisfaction in oncology with a focus on health related quality of life","volume":"9","author":"Lis","year":"2009","journal-title":"BMC Health Serv Res"},{"key":"2020061005543759800_ref2","volume-title":"NCCN Clinical Practice Guidelines in Oncology Cancer-Related Fatigue Cancer-Related Fatigue","author":"National Comprehensive Cancer Network","year":"2019"},{"key":"2020061005543759800_ref3","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1056\/NEJMoa1606774","article-title":"Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer","volume":"375","author":"Reck","year":"2016","journal-title":"N Engl J Med"},{"key":"2020061005543759800_ref4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0885-3924(96)00042-5","article-title":"Prevalence of symptoms among patients with advanced cancer: an international collaborative study. 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