{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:11:56Z","timestamp":1785553916588,"version":"3.56.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Cancer Center Research and Development Funds","award":["29-A-3"],"award-info":[{"award-number":["29-A-3"]}]},{"name":"National Cancer Center Research and Development Funds","award":["26-A-4"],"award-info":[{"award-number":["26-A-4"]}]},{"name":"National Cancer Center Research and Development Funds","award":["23-A-17"],"award-info":[{"award-number":["23-A-17"]}]},{"name":"National Cancer Center Research and Development Funds","award":["23-A-16"],"award-info":[{"award-number":["23-A-16"]}]},{"name":"Grants-in Aid for Cancer Research","award":["20S-6"],"award-info":[{"award-number":["20S-6"]}]},{"name":"Grants-in Aid for Cancer Research","award":["20S-1"],"award-info":[{"award-number":["20S-1"]}]},{"name":"Grants-in Aid for Cancer Research","award":["18-06"],"award-info":[{"award-number":["18-06"]}]},{"name":"Grants-in Aid for Cancer Research","award":["17S-5"],"award-info":[{"award-number":["17S-5"]}]},{"name":"Grants-in Aid for Cancer Research","award":["17S-1"],"award-info":[{"award-number":["17S-1"]}]},{"name":"Health Sciences Research Grants for Clinical Cancer Research","award":["H22-020"],"award-info":[{"award-number":["H22-020"]}]},{"name":"Health Sciences Research Grants for Clinical Cancer Research","award":["H19-028"],"award-info":[{"award-number":["H19-028"]}]},{"name":"Health Sciences Research Grants for the Third-Term Comprehensive Control Research for Cancer","award":["H16-035"],"award-info":[{"award-number":["H16-035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>Computed tomography of the abdomen and pelvis is a useful imaging modality for identifying origin and extent of ovarian cancer before primary debulking surgery. However, the International Federation of Gynecology and Obstetrics staging for ovarian cancer is determined based on surgico-pathological findings. The purpose of this study is to determine whether computed tomography staging can be the surrogate for surgico-pathological International Federation of Gynecology and Obstetrics staging in advanced ovarian cancer undergoing neoadjuvant chemotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Computed tomography staging was compared with surgico-pathological International Federation of Gynecology and Obstetrics staging in primary debulking surgery arm patients in a randomized controlled trial comparing primary debulking surgery and neoadjuvant chemotherapy (JCOG0602). The cancer of primary debulking surgery arm was identically diagnosed regarding the origin and extent with the cancer of neoadjuvant chemotherapy arm before accrual, using imaging studies (computed tomography and\/or magnetic resonance imaging), cytological examination (ascites, pleural effusion or tumor contents fluid) and tumor marker (CA125\u00a0&amp;gt;\u00a0200\u00a0U\/mL and CEA &amp;lt; 20\u00a0ng\/mL). Institutional computed tomography staging was also compared with computed tomography staging by central review.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 149 primary debulking surgery arm patients, 147 patients who underwent primary debulking surgery immediately were analyzed. Positive predictive values and sensitivity of computed tomography staging for surgical stage III disease (extra-pelvic peritoneal disease and\/or retroperitoneal lymph node metastasis) were 99%. Meanwhile, positive predictive values for the presence of small (\u22642\u00a0cm) extra-pelvic peritoneal disease were low; &amp;lt;20% in omentum. Accuracy of institutional computed tomography staging was comparable with computed tomography staging by central review.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Preoperative computed tomography staging in each institution can be the surrogate for surgico-pathological diagnosis in stage III disease of ovarian cancer patients undergoing neoadjuvant chemotherapy without diagnostic surgery, but reliability of diagnosis of stage IIIB disease is inadequate.<\/jats:p>\n                  <jats:p>Clinical trial registration: UMIN000000523(UMIN-CTR).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyaa145","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T11:36:36Z","timestamp":1597232196000},"page":"205-212","source":"Crossref","is-referenced-by-count":16,"title":["Stage III disease of ovarian, tubal and peritoneal cancers can be accurately diagnosed with pre-operative CT. Japan Clinical Oncology Group Study JCOG0602"],"prefix":"10.1093","volume":"51","author":[{"given":"Takashi","family":"Onda","sequence":"first","affiliation":[{"name":"Center for Gynecological Oncology and Gynecology, Sanno Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko Oishi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Kitai","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Jikei University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ito Municipal Hospital, Ito, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Hasumi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mitsui Memorial Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office, National Cancer Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gakuto","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office, National Cancer Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyomi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Gynecology Service, National Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kasamatsu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Japan Clinical Oncology Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"2021020810255982900_ref1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1471-0528.1989.tb03341.x","article-title":"Revised FIGO staging for gynaecological cancer","volume":"96","author":"Shepherd","year":"1989","journal-title":"Br J Obstet Gynaecol"},{"key":"2021020810255982900_ref2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1056\/NEJMoa0908806","article-title":"Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer","volume":"363","author":"Vergote","year":"2010","journal-title":"N Engl J Med"},{"key":"2021020810255982900_ref3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(14)62223-6","article-title":"Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial","volume":"386","author":"Kehoe","year":"2015","journal-title":"Lancet"},{"key":"2021020810255982900_ref4","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1200\/JCO.2016.68.6907","article-title":"Neoadjuvant chemotherapy for newly diagnosed, advanced ovarian cancer: Society of Gynecologic Oncology and American Society of clinical oncology clinical practice guideline","volume":"34","author":"Wright","year":"2016","journal-title":"J Clin Oncol"},{"key":"2021020810255982900_ref5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ygyno.2016.05.022","article-title":"Neoadjuvant chemotherapy for newly diagnosed, advanced ovarian cancer: Society of Gynecologic Oncology and American Society of clinical oncology clinical practice guideline","volume":"143","author":"Wright","year":"2016","journal-title":"Gynecol Oncol"},{"key":"2021020810255982900_ref6","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1200\/JCO.2016.68.1239","article-title":"Use and effectiveness of neoadjuvant chemotherapy for treatment of ovarian cancer","volume":"34","author":"Meyer","year":"2016","journal-title":"J Clin Oncol"},{"key":"2021020810255982900_ref7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejca.2020.02.020","article-title":"Comparison of survival between primary debulking surgery and neoadjuvant chemotherapy for stage III\/IV ovarian, tubal and peritoneal cancers in phase III randomised trial","volume":"130","author":"Onda","year":"2020","journal-title":"Eur J Cancer"},{"key":"2021020810255982900_ref8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/jjco\/hyh007","article-title":"Feasibility study of neoadjuvant chemotherapy followed by interval cytoreductive surgery for stage III\/IV ovarian, tubal and peritoneal cancers: Japan clinical oncology group study JCOG0206","volume":"34","author":"Onda","year":"2004","journal-title":"Jpn J Clin Oncol"},{"key":"2021020810255982900_ref9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ygyno.2008.12.027","article-title":"Feasibility study of neoadjuvant chemotherapy followed by interval debulking surgery for stage III\/IV ovarian, tubal, and peritoneal cancers: Japan clinical oncology group study JCOG0206","volume":"113","author":"Onda","year":"2009","journal-title":"Gynecol Oncol"},{"key":"2021020810255982900_ref10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/jjco\/hym145","article-title":"Phase III trial of upfront debulking surgery versus neoadjuvant chemotherapy for stage III\/IV ovarian, tubal and peritoneal cancers: Japan clinical oncology group study JCOG0602","volume":"38","author":"Onda","year":"2008","journal-title":"Jpn J Clin Oncol"},{"key":"2021020810255982900_ref11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejca.2016.05.017","article-title":"Comparison of treatment invasiveness between upfront debulking surgery versus interval debulking surgery following neoadjuvant chemotherapy for stage III\/IV ovarian, tubal, and peritoneal cancers in a phase III randomised trial: Japan clinical oncology group study JCOG0602","volume":"64","author":"Onda","year":"2016","journal-title":"Eur J Cancer"},{"key":"2021020810255982900_ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijgo.2013.10.001","article-title":"Staging classification for cancer of the ovary, fallopian tube, and peritoneum","volume":"124","author":"Prat","year":"2014","journal-title":"Int J Gynaecol Obstet"},{"key":"2021020810255982900_ref13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1148\/radiol.2232011081","article-title":"Peritoneal metastases: detection with spiral CT in patients with ovarian cancer","volume":"223","author":"Coakley","year":"2002","journal-title":"Radiology"},{"key":"2021020810255982900_ref14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/RLU.0b013e31826390ec","article-title":"Peritoneal carcinomatosis in patients with ovarian cancer: enhanced CT versus 18F-FDG PET\/CT","volume":"38","author":"Kim","year":"2013","journal-title":"Clin Nuclear Med"},{"key":"2021020810255982900_ref15","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1148\/radiology.215.3.r00jn25761","article-title":"Staging of advanced ovarian cancer: comparison of imaging modalities--report from the radiological diagnostic oncology group","volume":"215","author":"Tempany","year":"2000","journal-title":"Radiology"},{"key":"2021020810255982900_ref16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ygyno.2009.10.059","article-title":"Diagnosis and staging of primary ovarian cancer: correlation between PET\/CT, Doppler US, and CT or MRI","volume":"116","author":"Nam","year":"2010","journal-title":"Gynecol Oncol"},{"key":"2021020810255982900_ref17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/00004728-200305000-00006","article-title":"Thin section dual-phase multidetector-row computed tomography detection of peritoneal metastases in gynecologic cancers","volume":"27","author":"Pannu","year":"2003","journal-title":"J Comput Assist Tomography"},{"key":"2021020810255982900_ref18","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1148\/radiology.169.3.3186993","article-title":"Peritoneal implants from ovarian tumors: CT findings","volume":"169","author":"Buy","year":"1988","journal-title":"Radiology"},{"key":"2021020810255982900_ref19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2214\/AJR.08.1753","article-title":"Diffusion-weighted MRI of peritoneal tumors: comparison with conventional MRI and surgical and histopathologic findings--a feasibility study","volume":"193","author":"Low","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"2021020810255982900_ref20","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/1097-0142(19930901)72:5<1631::AID-CNCR2820720523>3.0.CO;2-I","article-title":"Evaluation of computed tomography in patients with peritoneal carcinomatosis","volume":"72","author":"Jacquet","year":"1993","journal-title":"Cancer"},{"key":"2021020810255982900_ref21","first-page":"398","article-title":"PET-CT detection of abdominal recurrence of ovarian cancer: radiologic-surgical correlation","volume":"29","author":"Pannu","year":"2004","journal-title":"Abdominal Imag"},{"key":"2021020810255982900_ref22","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.ejrad.2011.01.112","article-title":"Computer tomography, magnetic resonance imaging, and positron emission tomography or positron emission tomography\/computer tomography for detection of metastatic lymph nodes in patients with ovarian cancer: a meta-analysis","volume":"81","author":"Yuan","year":"2012","journal-title":"Eur J Radiol"},{"key":"2021020810255982900_ref23","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.crad.2008.09.011","article-title":"MRI appearances of borderline ovarian tumours","volume":"64","author":"Bent","year":"2009","journal-title":"Clin Radiol"},{"key":"2021020810255982900_ref24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1046\/j.1365-2303.1998.00061.x","article-title":"Peritoneal fluid cytology in serous borderline tumours of the ovary","volume":"9","author":"Stewart","year":"1998","journal-title":"Cytopathol: Off J Brit Soc Clin Cytol"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/51\/2\/205\/36212660\/hyaa145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/51\/2\/205\/36212660\/hyaa145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T20:13:32Z","timestamp":1612815212000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/51\/2\/205\/5896866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,8,25]]},"published-print":{"date-parts":[[2021,2,8]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyaa145","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2]]},"published":{"date-parts":[[2020,8,25]]}}}