{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:57:14Z","timestamp":1787065034757,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The significance of lymphadenectomy is yet to be fully examined in segmentectomy. We compared the oncological outcomes of mediastinal lymph node dissection (LND) and hilar LND for lung cancer treated with segmentectomy via a multicenter database using propensity score-matched analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed 357 clinical stage IA radiologically solid-dominant lung cancer patients who underwent segmentectomy with lymphadenectomy. The extent of LND was classified into systematic\/lobe-specific mediastinal LND and hilar LND only groups. Postoperative results after segmentectomy with mediastinal LND (n\u00a0=\u00a0179) and hilar LND (n\u00a0=\u00a0178) were analyzed for all patients and their propensity score-matched pairs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cancer-specific survival (CSS) and recurrence-free interval (RFI) rates for the mediastinal LND group were determined to be not significantly different compared with the hilar LND group in all non-adjusted cohorts. In the propensity score-matched cohort (129 pairs), mediastinal LND harvested more lymph nodes compared with hilar LND, and both groups had significantly different pathological stages (P\u00a0=\u00a00.015). Adjuvant chemotherapy was performed in 10 (7.8%) patients in the mediastinal LND group and 4 (3.1%) in the hilar LND group. The mediastinal LND group tended to have better prognosis than the hilar LND group (5-year CSS rates, 97.4% vs 93.2%; 5-year RFI rates, 93.5% vs 88.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mediastinal LND was found to provide more appropriate pathological staging compared with hilar LND in patients with segmentectomy by harvesting more lymph nodes. In addition, mediastinal LND might lead to better oncological outcome than hilar LND in segmentectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyaa199","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T07:19:20Z","timestamp":1601882360000},"page":"451-458","source":"Crossref","is-referenced-by-count":9,"title":["Appropriate Extent of Lymphadenectomy in Segmentectomy: A Multicenter Study"],"prefix":"10.1093","volume":"51","author":[{"given":"Yoshinori","family":"Handa","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-1027","authenticated-orcid":false,"given":"Yasuhiro","family":"Tsutani","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mimae","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morihito","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"2021030800224940900_ref1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0003-4975(95)00537-U","article-title":"Randomized trial of lobectomy versus. Limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group","volume":"60","author":"Ginsberg","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"2021030800224940900_ref2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J Thorac Oncol"},{"key":"2021030800224940900_ref3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cncr.11530","article-title":"Characteristics and prognosis of patients after resection of nonsmall cell lung carcinoma measuring 2 cm or less in greatest dimension","volume":"98","author":"Okada","year":"2003","journal-title":"Cancer"},{"key":"2021030800224940900_ref4","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.athoracsur.2007.05.007","article-title":"Anatomic segmentectomy in the treatment of stage I non\u2013small cell lung cancer","volume":"84","author":"Schuchert","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"2021030800224940900_ref5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ejcts.2006.08.008","article-title":"ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer","volume":"30","author":"Lardinois","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021030800224940900_ref6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jtcvs.2011.10.037","article-title":"Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting the pathological malignant grade of tumors in clinical stage IA lung adenocarcinoma: a multicenter study","volume":"143","author":"Tsutani","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021030800224940900_ref7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1378\/chest.13-1094","article-title":"Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma: wedge resection or segmentectomy","volume":"145","author":"Tsutani","year":"2014","journal-title":"Chest"},{"key":"2021030800224940900_ref8","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa032792","article-title":"A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung","volume":"350","author":"Kato","year":"2004","journal-title":"N Engl J Med"},{"key":"2021030800224940900_ref9","volume-title":"Non-small cell lung cancer (version 3. 2014)","author":"National Comprehensive Cancer Network"},{"key":"2021030800224940900_ref10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jtho.2015.10.007","article-title":"Nodal upstaging is more common with thoracotomy than with VATS during lobectomy for early-stage lung cancer: an analysis from the National Cancer Data Base","volume":"11","author":"Medbery","year":"2016","journal-title":"J Thorac Oncol"},{"key":"2021030800224940900_ref11","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1245\/s10434-012-2829-x","article-title":"Predictive factors of lymph node status in small peripheral non-small cell lung cancers: tumor histology is more reliable","volume":"20","author":"Zhang","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"2021030800224940900_ref12","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.athoracsur.2016.05.071","article-title":"Re-assessment of intentional extended Segmentectomy for clinical T1aN0 non-small cell lung cancer","volume":"102","author":"Nishio","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"2021030800224940900_ref13","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1056\/NEJMoa043623","article-title":"Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer","volume":"352","author":"Winton","year":"2005","journal-title":"N Engl J Med"},{"key":"2021030800224940900_ref14","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1378\/chest.128.3.1545","article-title":"Postoperative survival and the number of lymph nodes sampled during resection of node-negative non-small cell lung cancer","volume":"128","author":"Ludwig","year":"2005","journal-title":"Chest"},{"key":"2021030800224940900_ref15","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.athoracsur.2005.06.066","article-title":"Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial","volume":"81","author":"Allen","year":"2006","journal-title":"Ann Thorac Surg"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/51\/3\/451\/36446225\/hyaa199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/51\/3\/451\/36446225\/hyaa199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T19:23:04Z","timestamp":1615144984000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/51\/3\/451\/5988195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,11,18]]},"published-print":{"date-parts":[[2021,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyaa199","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3]]},"published":{"date-parts":[[2020,11,18]]}}}