{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:50:49Z","timestamp":1745567449777,"version":"3.37.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Beijing Municipal Science and Technology Project","award":["Z201100005620007"],"award-info":[{"award-number":["Z201100005620007"]}]},{"name":"Beijing Hospital Clinical Research 121 Project","award":["BJ-2018-090"],"award-info":[{"award-number":["BJ-2018-090"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874094"],"award-info":[{"award-number":["81874094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["2019-1002-69"],"award-info":[{"award-number":["2019-1002-69"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the role of Ki-67 in predicting subsequent intravesical recurrence following radical nephroureterectomy and to develop a predictive nomogram for upper tract urothelial carcinoma patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective analysis involved 489 upper tract urothelial carcinoma patients who underwent radical nephroureterectomy with bladder cuff excision. The data set was randomly split into a training cohort of 293 patients and a validation cohort of 196 patients. Immunohistochemical analysis was used to assess the immunoreactivity of the biomarker Ki-67 in the tumor tissues. A multivariable Cox regression model was utilized to identify independent intravesical recurrence predictors after radical nephroureterectomy before constructing a nomographic model. Predictive accuracy was quantified using time-dependent receiver operating characteristic curve. Decision curve analysis was performed to evaluate the clinical benefit of models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>With a median follow-up of 54\u00a0months, intravesical recurrence developed in 28.2% of this sample (n\u00a0=\u00a0137). Tumor location, multifocality, pathological T stage, surgical approach, bladder cancer history and Ki-67 expression levels were independently associated with intravesical recurrence (all P\u00a0&amp;lt;\u00a00.05). The full model, which intercalated Ki-67 with traditional clinicopathological parameters, outperformed both the basic model and Xylinas\u2019 model in terms of discriminative capacity (all P\u00a0&amp;lt;\u00a00.05). Decision-making analysis suggests that the more comprehensive model can also improve patients\u2019 net benefit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This new model, which intercalates the Ki-67 biomarker with traditional clinicopathological factors, appears to be more sensitive than nomograms previously tested across mainland Chinese populations. The findings suggest that Ki-67 could be useful for determining risk-stratified surveillance protocols following radical nephroureterectomy and in generating an individualized strategy based around intravesical recurrence predictions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyab017","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T17:27:47Z","timestamp":1612373267000},"page":"1132-1141","source":"Crossref","is-referenced-by-count":3,"title":["Developing a nomogram for predicting intravesical recurrence after radical nephroureterectomy: a retrospective cohort study of mainland Chinese patients"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2172-6583","authenticated-orcid":false,"given":"Shicong","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Urology, Beijing Hospital, Beijing, China"},{"name":"National Center of Gerontology, Beijing, China"},{"name":"Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingbo","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Hospital, Beijing, China"},{"name":"National Center of Gerontology, Beijing, China"},{"name":"Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Hospital, Beijing, China"},{"name":"National Center of Gerontology, Beijing, China"},{"name":"Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Hospital, Beijing, China"},{"name":"National Center of Gerontology, Beijing, China"},{"name":"Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Seery","sequence":"additional","affiliation":[{"name":"School of Humanities and Social Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"},{"name":"Division of Health Research, Faculty of Health and Medicine, Lancaster University, Lancaster, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Hospital, Beijing, China"},{"name":"National Center of Gerontology, Beijing, China"},{"name":"Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Hospital, Beijing, China"},{"name":"National Center of Gerontology, Beijing, China"},{"name":"Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Hospital, Beijing, China"},{"name":"National Center of Gerontology, Beijing, China"},{"name":"Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"2021070107534732500_ref1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.eururo.2020.05.042","article-title":"European Association of Urology Guidelines on upper urinary tract urothelial carcinoma: 2020 update","volume":"79","author":"Roupr\u00eat","year":"2020","journal-title":"Eur 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