{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:33:05Z","timestamp":1779316385957,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The incidence and background factors of sarcopenia and obesity in long-term survivors of childhood leukemia\/lymphoma were not clear in Japan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between August 2018 and September 2019, we recruited adults aged \u226518 years who had childhood leukemia\/lymphoma. Blood sampling, body composition measurement by bioelectrical impedance analysis and grip strength test were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 81 adult survivors (34 men and 47 women) with a median age of 25.0 years, 9 (11%) had sarcopenia and 10 (12%) had obesity, of whom, 3 had metabolic syndrome. Sarcopenia was observed in 7 (21%) of 33 survivors with hematopoietic stem cell transplantation (HSCT) and 2 (4%) of 48 survivors without hematopoietic stem cell transplantation (P = 0.012). The incidence of obesity was significantly higher in the cranial radiotherapy (P = 0.021) and non-transplanted cases (P = 0.042). Univariate logistic regression analysis revealed that hematopoietic stem cell transplantation for sarcopenia (odds ratio, 6.19; 95% confidence interval, 1.2\u201332.0; P = 0.03) and cranial radiotherapy for obesity (odds ratio, 5.6; 95% confidence interval, 1.4\u201322.4; P = 0.015) were significantly associated. Hypertension was more prevalent among the obese survivors, and higher transaminase levels were found more in both the sarcopenia and obese survivors than in others.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Young adult survivors of childhood leukemia\/lymphoma could be at risk of developing sarcopenia after hematopoietic stem cell transplantation and obesity after cranial radiotherapy. Further studies are required to assess the body composition of long-term survivors to find detailed risk factors of sarcopenia and metabolic syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyab046","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T12:15:10Z","timestamp":1615551310000},"page":"1100-1106","source":"Crossref","is-referenced-by-count":15,"title":["Sarcopenia and obesity in long-term survivors of childhood leukemia\/lymphoma: a report from a single institution"],"prefix":"10.1093","volume":"51","author":[{"given":"Hideki","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Pediatrics, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiji","family":"Fukano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"},{"name":"Department of Pediatrics, Yamaguchi University Hospital, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaki","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizu","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Division of Rehabilitation, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Yoshimaru","sequence":"additional","affiliation":[{"name":"Division of Nutrition, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Namie","sequence":"additional","affiliation":[{"name":"Department of Nursing, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mototsugu","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"},{"name":"Department of Biostatistics, Yamaguchi University Graduate School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"2021070819371039300_ref1","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/S0140-6736(17)31610-0","article-title":"The cumulative burden of surviving childhood cancer: an initial report from the St Jude lifetime cohort study (SJLIFE)","volume":"390","author":"Bhakta","year":"2017","journal-title":"Lancet"},{"key":"2021070819371039300_ref2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/cas.13457","article-title":"Childhood cancer incidence and survival in Japan and England: a population-based study (1993\u20132010)","volume":"109","author":"Nakata","year":"2018","journal-title":"Cancer Sci"},{"key":"2021070819371039300_ref3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1158\/1055-9965.EPI-14-1418","article-title":"Survivors of childhood cancer in the United States: prevalence and burden of morbidity","volume":"24","author":"Phillips","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2021070819371039300_ref4","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/jjco\/hyu102","article-title":"General health status and late effects among adolescent and young adult survivors of childhood cancer in Japan","volume":"44","author":"Ozono","year":"2014","journal-title":"Jpn J Clin Oncol"},{"key":"2021070819371039300_ref5","first-page":"849","article-title":"Obesity and metabolic disease after childhood cancer","volume":"29","author":"Barnea","year":"2015","journal-title":"Oncology"},{"key":"2021070819371039300_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01134-3","article-title":"Late outcome in survivors of childhood acute myeloid leukemia: a report from the St. Jude Lifetime Cohort Study","author":"Bhatt","journal-title":"Leukemia"},{"key":"2021070819371039300_ref7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s12185-010-0584-y","article-title":"Late effects and quality of life of childhood cancer survivors: part 1. 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