{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:58:25Z","timestamp":1773403105207,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Limb-salvage following resection of bone sarcomas of the foot are challenging due to the complicated anatomy, adjacent neurovascular structures and few durable reconstruction options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed 50 patients with primary malignant bone sarcoma of the foot who underwent surgery including chondrosarcoma (n\u00a0=\u00a023), Ewing\u2019s sarcoma (n\u00a0=\u00a014) and osteosarcoma (n\u00a0=\u00a013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median follow-up was 68\u00a0months. The primary sites were metatarsal (n\u00a0=\u00a018), phalanges (n\u00a0=\u00a015), calcaneus (n\u00a0=\u00a013) and others (n\u00a0=\u00a04). The 5-year disease-specific survivals were 100, 83 and 83% in chondrosarcoma, Ewing\u2019s sarcoma and osteosarcoma, respectively. Below knee amputation, ray\/toe amputation, excision and curettage were performed in 21, 24, 2 and 3 patients, respectively. Below knee amputation was performed in 94% of mid\/hindfoot tumours. Surgical margins were wide\/radical, marginal and intralesional margin in 42, 5 and 3 patients. Three patients (6%) developed local recurrence, whereas, local recurrence was not observed in patients with wide\/radical margins. Postoperative complications occurred in 3 patients (6%; surgical site infection n\u00a0=\u00a02 and delayed wound healing n\u00a0=\u00a01). Mean MSTS functional score was 26 points (range, 19\u201330).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Good local control was achieved with acceptable functional outcomes and post-operative complications; almost all mid\/hindfoot tumours required below knee amputation achieving wide\/radical margins without local recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jjco\/hyab118","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T19:23:01Z","timestamp":1627586581000},"page":"1541-1546","source":"Crossref","is-referenced-by-count":8,"title":["Surgical outcomes of bone sarcoma of the foot"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2404-7714","authenticated-orcid":false,"given":"Yusuke","family":"Tsuda","sequence":"first","affiliation":[{"name":"Oncology Department, Royal Orthopaedic Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Oncology Department, Royal Orthopaedic Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Oncology Department, Royal Orthopaedic Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adesegun","family":"Abudu","sequence":"additional","affiliation":[{"name":"Oncology Department, Royal Orthopaedic Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"2021100512322440400_ref1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.2106\/00004623-199508000-00003","article-title":"Prosthetic survival and clinical results with use of large-segment replacements in the treatment of high-grade bone sarcomas","volume":"77","author":"Malawer","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"2021100512322440400_ref2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1302\/2058-5241.2.160078","article-title":"Malignant tumours of the foot and ankle","volume":"2","author":"Mascard","year":"2017","journal-title":"EFORT Open Rev"},{"key":"2021100512322440400_ref3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jso.24817","article-title":"Management of primary malignant bone and soft tissue tumors of foot and ankle: Is it worth salvaging?","volume":"117","author":"\u00d6zger","year":"2018","journal-title":"J Surg Oncol"},{"key":"2021100512322440400_ref4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.foot.2019.06.007","article-title":"Functional and oncological outcomes of limb-salvage surgery for foot and ankle tumors","volume":"41","author":"Ebeid","year":"2019","journal-title":"Foot (Edinb)"},{"key":"2021100512322440400_ref5","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.3928\/01477447-20190523-05","article-title":"Total talectomy and reconstruction using a 3-dimensional printed talus prosthesis for Ewing's sarcoma: A 3.5-Year Follow-up","volume":"42","author":"Papagelopoulos","year":"2019","journal-title":"Orthopedics"},{"key":"2021100512322440400_ref6","first-page":"370","volume-title":"WHO classification of tumours editorial board","author":"Hogendoorn","year":"2020","edition":"5th"},{"key":"2021100512322440400_ref7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00003086-198011000-00013","article-title":"A system for the surgical staging of musculoskeletal sarcoma","volume":"153","author":"Enneking","year":"1980","journal-title":"Clin Orthop Relat Res"},{"key":"2021100512322440400_ref8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00003086-199301000-00035","article-title":"A system for the functional evaluation of reconstructive procedures after surgical treatmentof tumors of the musculoskeletal system","volume":"286","author":"Enneking","year":"1993","journal-title":"Clin Orthop Relat Res"},{"key":"2021100512322440400_ref9","doi-asserted-by":"crossref","first-page":"vii100","DOI":"10.1093\/annonc\/mds254","article-title":"Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"23","author":"ESMO\/European Sarcoma Network Working Group","year":"2012","journal-title":"Ann Oncol"},{"key":"2021100512322440400_ref10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.jfas.2014.01.015","article-title":"Review of foot tumors seen in a university tumor institute","volume":"53","author":"Ruggieri","year":"2014","journal-title":"J Foot Ankle Surg"},{"key":"2021100512322440400_ref11","first-page":"264","volume-title":"Osteosarcoma. 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