{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:20:13Z","timestamp":1763018413522,"version":"3.37.3"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Soft tissue sarcomas in the elbow are extremely rare, and they have primarily been described in case series. Definitive concerning the prevalence and prognostic factors of elbow soft tissue sarcomas remain unknown. We examined the outcome of patients with elbow soft tissue sarcomas and identified the relevant prognostic factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 219 patients with elbow soft tissue sarcomas were identified using data from the bone and soft tissue tumor registry in Japan. Differences in demographics, disease characteristics, treatment and survival were compared among the patients. Survival analyses including local recurrence-free survival, distant metastasis-free survival, and overall survival were performed using the Kaplan\u2013Meier method with log-rank tests and the Cox proportional hazards model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two hundred nineteen patients with elbow soft tissue sarcomas were identified, including 119 males (54.3%) and 100 females (45.7%). In total, 189 patients (86.3%) underwent surgery including re-excision. Of the surgically treated patients, 180 (95.2%) underwent limb salvage surgery, and nine patients (4.8%) underwent amputation. The 5-year overall survival, local recurrence-free survival, and distant metastasis-free survival rates for the entire patient cohort were 76.3, 70.1, and 69.3%, respectively. After adjusting for clinically relevant factors, overall survival was significantly worse among patients with tumors: &amp;gt;10\u00a0cm (hazard ratio\u00a0=\u00a04.34; 95% confidence interval\u00a0=\u00a01.03\u201318.2) and metastatic disease (hazard ratio\u00a0=\u00a06.94; 95% confidence interval\u00a0=\u00a01.55\u201331.0).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Tumor size was identified as an independent risk factor for poor prognosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyab119","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T11:08:52Z","timestamp":1626088132000},"page":"1608-1614","source":"Crossref","is-referenced-by-count":3,"title":["Oncological and prognostic analysis of soft tissue sarcoma of the elbow: report using the bone and soft tissue tumor registry in Japan"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-2795","authenticated-orcid":false,"given":"Makoto","family":"Emori","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousuke","family":"Iba","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Murahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Hokkaido Saiseikai Otaru Hospital, Otaru, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"2021110109442989000_ref1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3322\/canjclin.54.1.8","article-title":"Cancer statistics, 2004","volume":"54","author":"Jemal","year":"2004","journal-title":"CA Cancer J Clin"},{"key":"2021110109442989000_ref2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0360-3016(02)02904-8","article-title":"Outcome of primary soft tissue sarcoma of the knee and elbow","volume":"54","author":"Alektiar","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2021110109442989000_ref3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1302\/0301-620X.90B1.19958","article-title":"Wide en bloc extra-articular excision of the elbow for sarcoma with complex reconstruction","volume":"90","author":"Schwab","year":"2008","journal-title":"J Bone Joint Surg Br"},{"key":"2021110109442989000_ref4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jos.2017.03.017","article-title":"Statistics of soft-tissue sarcoma in Japan: Report from the Bone and Soft Tissue Tumor Registry in Japan","volume":"22","author":"Ogura","year":"2017","journal-title":"J Orthop Sci"},{"key":"2021110109442989000_ref5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00000658-198704000-00001","article-title":"Localized operable soft tissue sarcoma of the upper extremity. 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