{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:51:26Z","timestamp":1793296286448,"version":"4.5.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The ureterovesical junction is the boundary between the urinary bladder and upper urinary tract. Because treatment strategies for bladder cancer and upper tract urothelial carcinoma are entirely different, urothelial carcinoma involving the ureterovesical junction requires special attention. Nevertheless, studies focusing on the disease are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We reviewed consecutive patients with urothelial carcinoma treated via either transurethral resection of bladder tumor (n = 2791) or radical nephroureterectomy (n = 292) between 2000 and 2020 and identified those with bladder cancer involving the ureteral orifice (n = 64) and those with upper tract urothelial carcinoma involving the intramural ureter (\u22642 cm) (n = 41). After excluding overlapping cases (n = 24), 80 patients with urothelial carcinoma involving the ureterovesical junction were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The initial symptoms or reasons for diagnosing urothelial carcinoma involving the ureterovesical junction were hematuria (n = 30), hydronephrosis (n = 21), follow-up examinations for prior urothelial carcinoma (n = 13), screening examinations (n = 7), frequent urination (n = 6) and unknown causes (n = 3). During a median follow-up period of 42 months, 18 patients died of urothelial carcinoma. The definitive surgical treatments for urothelial carcinoma involving the ureterovesical junction were transurethral resection of bladder tumor alone (n = 26), radical nephroureterectomy (n = 41) and radical cystectomy (n = 13), with different treatments having different cancer-specific survivals. Multivariate analyses identified T stage (\u2265T2) as an independent predictor of shorter cancer-specific survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Given the positional property of urothelial carcinoma involving the ureterovesical junction, the profiles of patients with the disease were highly heterogeneous. Further optimization of treatment strategies for urothelial carcinoma involving the ureterovesical junction is urgently warranted for better clinical outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyab143","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:39:45Z","timestamp":1631101185000},"page":"65-72","source":"Crossref","is-referenced-by-count":5,"title":["Clinicopathological features and oncological outcomes of urothelial carcinoma involving the ureterovesical junction"],"prefix":"10.1093","volume":"52","author":[{"given":"Takahiro","family":"Oshina","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-4294","authenticated-orcid":false,"given":"Satoru","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"},{"name":"Department of Urology, Kyorin University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimpei","family":"Miyakawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketo","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Urology, Kyorin University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"2022010310215714300_ref1","volume-title":"Global Cancer Observatory: Cancer 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endoluminal ultrasonography in vitro","volume":"161","author":"Roshani","year":"1999","journal-title":"J Urol"},{"key":"2022010310215714300_ref6","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.juro.2012.08.006","article-title":"Resection of ureteral orifice during transurethral resection of bladder tumor: functional and oncologic implications","volume":"188","author":"Mano","year":"2012","journal-title":"J Urol"},{"key":"2022010310215714300_ref7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.humpath.2017.04.018","article-title":"Urothelial carcinoma involving the ureteral orifice: a clinicopathologic analysis of 93 cases","volume":"65","author":"Annan","year":"2017","journal-title":"Hum Pathol"},{"key":"2022010310215714300_ref8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1590\/s1677-5538.ibju.2017.0218","article-title":"Ureteral orifice involvement by urothelial carcinoma: long term oncologic and functional outcomes","volume":"43","author":"Altok","year":"2017","journal-title":"Int Braz J Urol"},{"key":"2022010310215714300_ref9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.aju.2018.06.004","article-title":"Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?","volume":"16","author":"Singh","year":"2018","journal-title":"Arab J Urol"},{"key":"2022010310215714300_ref10","doi-asserted-by":"crossref","first-page":"856","DOI":"10.21037\/tau.2019.09.14","article-title":"Fate of residual ureteral stump in patients undergoing robot-assisted radical nephroureterectomy for high-risk upper tract urothelial carcinoma","volume":"9","author":"Pathak","year":"2020","journal-title":"Transl Androl Urol"},{"key":"2022010310215714300_ref11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.urology.2020.06.083","article-title":"KYUS group. the remaining ipsilateral ureteral orifice provokes intravesical tumor recurrence after nephroureterectomy for upper tract urothelial carcinoma: a multicenter study with a mid-term follow-up","volume":"145","author":"Kwon","year":"2020","journal-title":"Urology"},{"key":"2022010310215714300_ref12","doi-asserted-by":"crossref","first-page":"E845","DOI":"10.5489\/cuaj.1985","article-title":"The impact of method of distal ureter management during radical nephroureterectomy on tumour recurrence","volume":"8","author":"Kapoor","year":"2014","journal-title":"Can Urol Assoc J"},{"key":"2022010310215714300_ref13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.eururo.2012.04.052","article-title":"Impact of distal ureter management on oncologic outcomes following radical nephroureterectomy for upper tract urothelial carcinoma","volume":"65","author":"Xylinas","year":"2014","journal-title":"Eur Urol"},{"key":"2022010310215714300_ref14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.eururo.2018.04.029","article-title":"Multiparametric magnetic resonance imaging for bladder cancer: development of VI-RADS (vesical imaging-reporting and data system)","volume":"74","author":"Panebianco","year":"2018","journal-title":"Eur Urol"},{"key":"2022010310215714300_ref15","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/JU.0000000000001373","article-title":"Prospective validation of vesical imaging-reporting and data system using a next-generation magnetic resonance imaging scanner-is denoising deep learning reconstruction useful?","volume":"205","author":"Taguchi","year":"2021","journal-title":"J Urol"},{"key":"2022010310215714300_ref16","volume-title":"105th Scientific Assembly and Annual Meeting of Radiological Society of North America (RSNA)","author":"Watanabe","year":"2019"}],"container-title":["Japanese Journal of Clinical 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