{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:01:15Z","timestamp":1792504875721,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anastomotic leakage is one of the most severe and critical complications of laparoscopic surgery for colorectal cancer. However, definitive preoperative predictors of anastomotic leakage remain elusive. With the ageing of society, the number of colorectal cancer patients with arteriosclerotic disease in Japan is increasing. This study was performed to evaluate the correlation between preoperative arteriosclerosis and anastomotic leakage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 98 patients undergoing laparoscopic surgery for colorectal cancer with reconstruction using the double-stapling technique without diversion of the stoma were enrolled in the study. Preoperative assessment of arteriosclerotic disease was performed by abdominal computed tomography. The calcification volume percentage of the aorta between the level of the celiac artery root and aortic bifurcation was calculated using ZIOstation2 software, and the relationship between arteriosclerosis and anastomotic leakage was analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 98 cases, anastomotic leakage was observed in 16 (16.3%). The median calcification volume percentage (range) was 2.35% (0\u201340.3%). Age, male sex, hypertension, dissection number, estimated glomerular filtration rate and tumour location were correlated with anastomotic leakage on statistical analysis. Statistical analysis showed that calcification volume percentage was one of the robust risk factors for anastomotic leakage (odds ratio: 1.09, 95% confidence interval: 1.03\u20131.17, P\u00a0&amp;lt;\u00a00.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Calcification of the abdominal aorta may be a promising predictor of AL after laparoscopic surgery for colorectal cancer reconstruction using the double-stapling technique.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyab196","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T23:06:36Z","timestamp":1638140796000},"page":"122-127","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of abdominal aortic calcification by plain CT predicts anastomotic leakage in laparoscopic surgery for colorectal cancer"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-8662","authenticated-orcid":false,"given":"Satoru","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Surgery, Keio University School of Medicine, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keio University School of Medicine, Tokyo"},{"name":"Department of Hepato-Biliary-Pancreatic & Gastrointestinal Surgery, International University of Health and Welfare Narita Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Okabayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keio University School of Medicine, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keio University School of Medicine, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Seishima","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keio University School of Medicine, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Monno","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keio University School of Medicine, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Itano","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic & Gastrointestinal Surgery, International University of Health and Welfare Narita Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keio University School of Medicine, Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"2022020901371879800_ref1","volume-title":"Laparoscopic Versus Open Surgery for Rectal Cancer (COLOR II): Short-Term Outcomes of a Randomised, Phase 3 Trial","author":"Pas MH","year":"2013"},{"key":"2022020901371879800_ref2","article-title":"Individual surgeon is an independent risk factor for leak after double-stapled colorectal anastomosis: An institutional analysis of 800 patients","volume-title":"Surgery.","author":"Garc Ia-Granero"},{"key":"2022020901371879800_ref3","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1007\/s00464-017-5611-0","article-title":"Influence of multiple stapler firings used for rectal division on colorectal anastomotic leak rate","volume":"31","author":"Braunschmid","year":"2017","journal-title":"Surg Endosc."},{"key":"2022020901371879800_ref4","article-title":"et\u00a0al","volume-title":"Int J Colorectal Dis.","author":"Matsumoto"},{"key":"2022020901371879800_ref5","doi-asserted-by":"crossref","DOI":"10.1007\/s11605-018-3931-6","article-title":"Influence of conversion and anastomotic leakage on survival in rectal cancer surgery; retrospective cross-sectional study","volume-title":"World J Gastrointest Surg.","author":"Furn\u00e9e"},{"key":"2022020901371879800_ref6","first-page":"670","article-title":"Long-term prognostic impact of surgical complications in the German Rectal Cancer Trial CAO\/ARO\/AIO-94","volume":"35","author":"Sprenger","year":"2017","journal-title":"Clin Oncol Gastrointest Cancers Symp."},{"key":"2022020901371879800_ref7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00595-015-1230-3","article-title":"Transanal drainage tube placement to prevent anastomotic leakage following colorectal cancer surgery with double stapling reconstruction","volume":"3","author":"Matsuda","year":"2016","journal-title":"Surg Today."},{"key":"2022020901371879800_ref8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/jjco\/hyz192","article-title":"Relationship between anastomotic leakage and CT value of the mesorectum in laparoscopic anterior resection for rectal cancer","volume":"50","author":"Iwama","year":"2020","journal-title":"Jpn J Clin Oncol."},{"key":"2022020901371879800_ref9","first-page":"927","article-title":"Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery","volume":"86","author":"S\u00f8rensen","year":"1999","journal-title":"Colorectal Surgery"},{"key":"2022020901371879800_ref10","article-title":"Lifestyle and 30-day complications to surgery for colorectal cancer","author":"Nickelsen","year":"2009","journal-title":"Acta Oncol."},{"key":"2022020901371879800_ref11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1463-1318.2004.00657.x","article-title":"Risk factors for anastomotic leakage after anterior resection of the rectum","volume":"6","author":"Matthiessen","year":"2004","journal-title":"Color Dis."},{"key":"2022020901371879800_ref12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1001\/archsurg.2012.77","article-title":"Risk factors for anastomotic leak and mortality in diabetic patients undergoing colectomy: Analysis from a statewide surgical quality collaborative","volume":"147","author":"Ziegler","year":"2012","journal-title":"Arch Surg."},{"key":"2022020901371879800_ref13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00268-001-0256-4","article-title":"Factors associated with clinically significant anastomotic leakage after large bowel resection: multivariate analysis of 707 patients","volume":"26","author":"Alves","year":"2002","journal-title":"World J Surg."},{"key":"2022020901371879800_ref14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10350-004-6627-9","article-title":"Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis","volume":"46","author":"M\u00e4kel\u00e4","year":"2003","journal-title":"Dis Colon Rectum."},{"key":"2022020901371879800_ref15","article-title":"et\u00a0al","volume-title":"Surgery.","author":"Scharff"},{"key":"2022020901371879800_ref16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0889-8553(05)70190-4","article-title":"Ischemic bowel disease in the elderly","volume":"30","author":"Greenwald","year":"2001","journal-title":"Gastroenterol Clin North Am."},{"key":"2022020901371879800_ref17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2019.11.023","article-title":"The relationship between aortic calcification and anastomotic leak following gastrointestinal resection: a systematic review","volume-title":"Int J Surg.","author":"Knight"},{"key":"2022020901371879800_ref18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000486143","article-title":"Influence of visceral fat in the outcomes of colorectal cancer","volume":"36","author":"Goulart","year":"2018","journal-title":"Dig Surg."},{"key":"2022020901371879800_ref19","article-title":"Evaluation of liver function using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging based on a three-dimensional volumetric analysis system","author":"Kudo","journal-title":"Hepatol Int."},{"key":"2022020901371879800_ref20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jcmg.2020.08.036","article-title":"The relationship between coronary calcification and the natural history of coronary artery disease","volume":"14","author":"Jin","year":"2021","journal-title":"JACC Cardiovasc Imaging."},{"key":"2022020901371879800_ref21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg."},{"key":"2022020901371879800_ref22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ejso.2018.01.225","article-title":"Generalized cardiovascular disease on a preoperative CT scan is predictive for anastomotic leakage after esophagectomy","volume":"44","author":"Borggreve","year":"2018","journal-title":"Eur J Surg Oncol."},{"key":"2022020901371879800_ref23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jviscsurg.2016.03.007","article-title":"Colorectal anastomotic leakage can be predicted by abdominal aortic calcification on preoperative CT scans: a pilot study","volume":"153","author":"Eveno","year":"2016","journal-title":"J Visc Surg."},{"key":"2022020901371879800_ref24","first-page":"1220","article-title":"Compromised visceral circulation does not affect the outcome of colorectal surgery","volume":"44","author":"Kornmann","year":"2013","journal-title":"Surg Today."},{"key":"2022020901371879800_ref25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/BF02237248","article-title":"Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak","volume":"43","author":"Vignali","year":"2000","journal-title":"Dis Colon Rectum."},{"key":"2022020901371879800_ref26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00000658-198709000-00011","article-title":"Blood flow in colonic anastomoses. Effect of stapling and suturing","volume":"206","author":"Chung","year":"1987","journal-title":"Ann Surg."},{"key":"2022020901371879800_ref27","article-title":"et\u00a0al","volume-title":"Int J Colorectal Dis.","author":"Watanabe"},{"key":"2022020901371879800_ref28","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1161\/01.CIR.92.8.2157","article-title":"Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area: a histopathologic correlative study","volume":"92","author":"Rumberger","year":"1995","journal-title":"Circulation."}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/52\/2\/122\/42404817\/hyab196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/52\/2\/122\/42404817\/hyab196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T21:04:07Z","timestamp":1644354247000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/52\/2\/122\/6479793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,12,23]]},"published-print":{"date-parts":[[2022,2,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyab196","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2]]},"published":{"date-parts":[[2021,12,23]]}}}