{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:19:09Z","timestamp":1767910749633,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770566"],"award-info":[{"award-number":["81770566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000599"],"award-info":[{"award-number":["82000599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Sichuan Science and Technology Department","award":["2019YFS0029"],"award-info":[{"award-number":["2019YFS0029"]}]},{"name":"Science and Technology Program of Sichuan Science and Technology Department","award":["2019YFS0529"],"award-info":[{"award-number":["2019YFS0529"]}]},{"name":"New Medical Technology Foundation of West China Hospital of Sichuan University","award":["XJS2016004"],"award-info":[{"award-number":["XJS2016004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The primary aim of this study was to assess the cumulative incidence of cause-specific mortality (CSM) and other cause-specific mortality (OCSM) for patients with advanced gallbladder cancer (GBC), and then to develop a nomogram based on competing-risk analysis to forecast CSM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We identified the patients with GBC with specific screening criteria and from the Surveillance Epidemiology and End Results (SEER) database. We calculated the cumulative incidence function for CSM and OCSM, and constructed a competing-risk nomogram based on the Fine and Gray\u2019s proportional subdistribution hazard regression model to forecast the probability of CSM of these patients. In addition, the concordance index and calibration plot were performed to validate the novel established model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1411 patients were included in this study. The 1-, 2-, and 3-year overall cumulative mortalities were 46.2, 62.2, and 69.6% for CSM, respectively, while they were 6.2, 8.7, and 10.4% for OCSM. Additionally, the 1-, 2-, and 3-year estimates of overall survival were 47.6, 29.1, and 19.9% for above these patients, respectively. We also developed a competing-risk nomogram to estimate the CSM. The concordance index was 0.775 (95% confidence interval (CI): 0.750\u20130.800) in the training set and that was 0.765 (95% CI: 0.730\u20130.800) in the internal validation set, which suggests the robustness of the novel established model. Furthermore, the calibration curves and concordance index demonstrated that the nomogram was well-calibrated and demonstrated good discriminative ability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The ample sample allowed us to develop a reliable model which demonstrated better calibration and discrimination for predicting the probability of CSM of patients with advanced GBC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyab212","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T12:20:01Z","timestamp":1640262001000},"page":"353-361","source":"Crossref","is-referenced-by-count":7,"title":["Competing-risk nomogram for predicting survival in patients with advanced (stage III\/IV) gallbladder cancer: A SEER population-based study"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7280-0566","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Liver Surgery & Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery & Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China"},{"name":"Department of Cardiology, Medical College of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery & Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery & Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery & Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"2022040612513572200_ref1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1634\/theoncologist.2009-0302","article-title":"Current management of gallbladder carcinoma","volume":"15","author":"Zhu","year":"2010","journal-title":"Oncologist"},{"key":"2022040612513572200_ref2","doi-asserted-by":"crossref","first-page":"967472","DOI":"10.1155\/2015\/967472","article-title":"Gallbladder cancer in the 21st century","volume":"2015","author":"Kanthan","year":"2015","journal-title":"J Oncol"},{"key":"2022040612513572200_ref3","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1007\/s00261-020-02871-2","article-title":"Current update on gallbladder carcinoma","volume":"46","author":"Ganeshan","year":"2021","journal-title":"Abdominal Radiol (New York)"},{"key":"2022040612513572200_ref4","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ejso.2013.02.010","article-title":"Carcinoma of the gallbladder: patterns of presentation, prognostic factors and survival rate. 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