{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:05:25Z","timestamp":1770897925186,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nuclear protein of the testis (NUT) midline carcinoma (NMC) is a rare tumor that typically presents in the head, neck, and chest region. NMC is characterized by rearrangement of the NUTM1 gene. It mainly affects children and young adults and is rapidly progressive and lethal. Reportedly, the prognoses of NMCs of the head and neck improve following aggressive initial surgical resection +\/\u2212 postoperative chemoradiotherapy (CRT) or radiotherapy (RT). However, as NMC of the thorax was identified later, treatments to improve its prognosis are yet to be identified. Our review reveals that NMC is an extremely rare cancer, and most patients remain undiagnosed. Furthermore, this review outlines the clinical characteristics of NMC of the thorax and the prospects for its treatment.<\/jats:p>","DOI":"10.1093\/jjco\/hyac033","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T20:12:50Z","timestamp":1646251970000},"page":"531-538","source":"Crossref","is-referenced-by-count":8,"title":["Nuclear protein of the testis midline carcinoma of the thorax"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-2022","authenticated-orcid":false,"given":"Ayae","family":"Saiki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine , , Tokyo, Japan"},{"name":"Japanese Red Cross Medical Center , , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine , , Tokyo, Japan"},{"name":"Japanese Red Cross Medical Center , , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Bee","sequence":"additional","affiliation":[{"name":"Department of Pathology , , Tokyo, Japan"},{"name":"Japanese Red Cross Medical Center , , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Izumo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine , , Tokyo, Japan"},{"name":"Japanese Red Cross Medical Center , , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"2022060109132064200_ref1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/pin.12727","article-title":"NUT carcinoma: Clinicopathologic features, pathogenesis, and treatment","volume":"68","author":"French","year":"2018","journal-title":"Pathol Int"},{"key":"2022060109132064200_ref2","first-page":"3327","article-title":"Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma","volume":"51","author":"Kubonishi","year":"1991","journal-title":"Cancer Res"},{"key":"2022060109132064200_ref3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00043426-199124000-00011","article-title":"Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19)","volume":"13","author":"Kees","year":"1991","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"2022060109132064200_ref4","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1002\/1097-0142(19931001)72:7<2273::AID-CNCR2820720735>3.0.CO;2-U","article-title":"Disseminated mediastinal carcinoma with chromosomal trans- location (15;19). A distinctive clinicopathologic syndrome","volume":"72","author":"Lee","year":"1993","journal-title":"Cancer"},{"key":"2022060109132064200_ref5","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/1097-0142(20010901)92:5<1195::AID-CNCR1438>3.0.CO;2-3","article-title":"Upper respiratory tract carcinoma with chromosomal translocation 15;19: evidence for a distinct disease entity of young patients with a rapidly fatal course","volume":"92","author":"Vargas","year":"2001","journal-title":"Cancer"},{"key":"2022060109132064200_ref6","first-page":"304","article-title":"BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma","volume":"63","author":"French","year":"2003","journal-title":"Cancer Res"},{"key":"2022060109132064200_ref7","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1200\/JCO.2004.02.107","article-title":"Midline carcinoma of children and young adults with NUT rearrangement","volume":"22","author":"French","year":"2004","journal-title":"J Clin 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