{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:34Z","timestamp":1753877074858,"version":"3.41.2"},"reference-count":22,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802915"],"award-info":[{"award-number":["81802915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the prognostic value of S-100 protein and Ki-67 labeling index in olfactory neuroblastomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective study was conducted on a cohort of 85 patients with olfactory neuroblastomas. The immunohistochemical expression of S-100 and Ki-67 was assessed, and the predictive value of S-100 and Ki-67 was further evaluated. The optimal cutoff value of Ki-67 labeling index was determined using time-dependent receiver operating characteristic curve analysis. Overall survival and progression-free survival were assessed using the Kaplan\u2013Meier method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A cut-off Ki-67 labeling index value of 67.5% was determined for prognosis in patients with olfactory neuroblastomas. There was a significant correlation between Ki-67 expression and cervical lymph node metastasis (P\u00a0=\u00a00.049). Compared with S-100 (+), S-100 (\u2212) was associated with a higher rate of lymph node metastasis and a higher level of Ki-67 (P\u00a0=\u00a00.007,\u00a0&amp;lt;\u00a00.001, respectively), as well as an advanced Kadish stage (P\u00a0=\u00a00.037). Survival analyses showed that patients with S-100 (+) had better 5-year overall survival than those with S-100 (\u2212) (P\u00a0=\u00a00.028), and patients with both S-100 (+) and Ki-67 (&amp;lt;67.5%) had superior 5-year overall survival compared with all the other patients (P\u00a0=\u00a00.0225).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings suggest that S-100 combined with Ki-67 labeling index are reliable prognostic factors in patients with olfactory neuroblastomas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyac094","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T05:36:24Z","timestamp":1657604184000},"source":"Crossref","is-referenced-by-count":1,"title":["The prognostic value of S-100 protein and Ki-67 index in olfactory neuroblastoma"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-4209","authenticated-orcid":false,"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology , Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianci","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology , Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , Eye & ENT Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"2022071205361692800_ref1","doi-asserted-by":"crossref","first-page":"E2259","DOI":"10.1002\/hed.24152","article-title":"Neuroendocrine neoplasms of the sinonasal region","volume":"38","author":"Bell","year":"2016","journal-title":"Head Neck"},{"key":"2022071205361692800_ref2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11060-020-03537-1","article-title":"Management of olfactory 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