{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:02:31Z","timestamp":1793851351989,"version":"4.6.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006692","name":"University of Turin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Complete mesocolic excision with central vascular ligation, or simply CME, includes the sharp dissection along the mesocolic visceral and parietal layers, with the ligation of the main vessels at their origins. To date, there is low evidence on its safety and efficacy. This is a study-protocol of a multicenter, randomized, superiority trial in patients with right-sided colon cancer. It aims to investigate whether the complete mesocolic excision improves the oncological outcomes as compared with conventional right hemicolectomy, without worsening early outcomes. Data on efficacy and safety of complete mesocolic excision are available only from a large trial recruiting eastern patients and from a low-volume single-center western study. No results on survival are still available. For this reason, complete mesocolic excision continues to be a controversial topic in daily practice, particularly in western world. This new nationwide multicenter large-volume trial aims to provide further data on western patients, concerning both postoperative and survival outcomes.<\/jats:p>","DOI":"10.1093\/jjco\/hyac116","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T20:38:50Z","timestamp":1658176730000},"source":"Crossref","is-referenced-by-count":6,"title":["Complete mesocolic excision in comparison with conventional surgery for right colon cancer: a nationwide multicenter study of the Italian Society of Surgical Oncology colorectal cancer network (CoME-in trial). Study protocol for a randomized controlled trial"],"prefix":"10.1093","author":[{"given":"Maurizio","family":"Degiuli","sequence":"first","affiliation":[{"name":"University of Turin, Department of Oncology, Surgical Oncology and Digestiver Surgery, San Luigi University Hospital , Orbassano, 10043 Torino , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Solej","sequence":"additional","affiliation":[{"name":"University of Turin, Department of Oncology, Surgical Oncology and Digestiver Surgery, San Luigi University Hospital , Orbassano, 10043 Torino , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hogla Aridai","family":"Resendiz Aguilar","sequence":"additional","affiliation":[{"name":"University of Turin, Department of Oncology, Surgical Oncology and Digestiver Surgery, San Luigi University Hospital , Orbassano, 10043 Torino , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Marchiori","sequence":"additional","affiliation":[{"name":"University of Turin, Department of Oncology, Surgical Oncology and Digestiver Surgery, San Luigi University Hospital , Orbassano, 10043 Torino , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-9953","authenticated-orcid":false,"given":"Rossella","family":"Reddavid","sequence":"additional","affiliation":[{"name":"University of Turin, Department of Oncology, Surgical Oncology and Digestiver Surgery, San Luigi University Hospital , Orbassano, 10043 Torino , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"2022071820384229400_ref1","first-page":"3","article-title":"Source: Globocan 2020","volume":"419","author":"WHO","year":"2020","journal-title":"Globocan 2020"},{"key":"2022071820384229400_ref2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/014107688808100904","article-title":"The \u201choly plane\u201d of rectal surgery","volume":"81","author":"Heald","year":"1988","journal-title":"J R Soc Med"},{"key":"2022071820384229400_ref3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1463-1318.2008.01735.x","article-title":"Standardized surgery for colonic cancer: complete mesocolic excision and central ligation--technical notes and outcome","volume":"11","author":"Hohenberger","year":"2009","journal-title":"Colorectal Dis"},{"key":"2022071820384229400_ref4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00384-013-1818-2","article-title":"The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery : proceedings of a consensus conference","volume":"29","author":"S\u00f8ndenaa","year":"2014","journal-title":"Int J Colorectal Dis"},{"key":"2022071820384229400_ref5","first-page":"1123","article-title":"Can the quality of colonic surgery be improved by standardization of surgical technique with complete mesocolic excision?","volume-title":"Colorectal Dis","author":"Bertelsen","year":"2011"},{"key":"2022071820384229400_ref6","volume-title":"Ann Laparosc Endosc Surg (AME Publishing Company)","author":"Reddavid","year":"2020"},{"key":"2022071820384229400_ref7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1470-2045(20)30685-9","article-title":"Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial","volume":"22","author":"Xu","year":"2021","journal-title":"Lancet Oncol"},{"key":"2022071820384229400_ref8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/SLA.0000000000004557","article-title":"Feasibility and safety of laparoscopic complete Mesocolic excision (CME) for right-sided colon cancer: short-term outcomes. 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