{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:23:36Z","timestamp":1783085016795,"version":"3.54.6"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Consumption of opioids, essential drugs for pain relief, has seen rapid growth worldwide. In Japan, where total opioid consumption still remains low among developed countries, little is known about trends in the clinical patterns of opioids in terminally ill cancer patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients who died of cancer from 2010 to 2019 were included in this study. Morphine, oxycodone, fentanyl, tapentadol, methadone and hydromorphone were examined as opioids for cancer pain. We calculated the prevalence of prescribed opioids prior to death by year and age group and the average opioid dose 30\u00a0days before death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The total number of patients was 221\u2009598. We found that the prescription prevalence of opioids increased from 60.8 to 65.9% (5.1%). Morphine was most prescribed in 2010 but had decreased prevalence (\u22129.0%) during the 10-year period. Oxycodone had the highest increase in prescription prevalence (13.7%), and fentanyl prevalence decreased (\u22124.9%). In the subgroup comparison, the prescription prevalence of opioids in the elderly was lower than that in the younger group; however, the increasing trend in the elderly was greater than that in the younger group. The percentage of patients prescribed low-dose opioids (&amp;lt;60\u00a0mg\/day) during the 30\u00a0days before death increased by 4.9% and was the highest throughout the study period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The prevalence of opioid prescriptions for terminally ill cancer patients has increased from 2010 to 2019 in Japan. The opioid-specific trends were similar to the global trend but differed by palliative care specialty.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyac122","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T02:28:58Z","timestamp":1659234538000},"page":"1297-1302","source":"Crossref","is-referenced-by-count":16,"title":["Trends in strong opioid prescription for cancer patients in Japan from 2010 to 2019: an analysis with large medical claims data"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4265-1787","authenticated-orcid":false,"given":"Richi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Medical Statistics, Toho University Graduate School of Medicine , Tokyo , Japan"},{"name":"Yokohama Cancer Chemotherapy & Palliative Care Support Division , Toda Medical Care Group, Kanagawa , Japan"},{"name":"Department of Palliative Nursing , Health Sciences, , Miyagi , Japan"},{"name":"Tohoku University Graduate School of Medicine , Health Sciences, , Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunori","family":"Miyashita","sequence":"additional","affiliation":[{"name":"Department of Palliative Nursing , Health Sciences, , Miyagi , Japan"},{"name":"Tohoku University Graduate School of Medicine , Health Sciences, , Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Faculty of Medicine, Toho University , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari S","family":"OBA","sequence":"additional","affiliation":[{"name":"Department of Clinical Data Science , Clinical Research & Education Promotion Division, , Tokyo , Japan"},{"name":"National Center of Neurology and Psychiatry , Clinical Research & Education Promotion Division, , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"2022111921522783100_ref1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/j.1532-2149.2014.496.x","article-title":"Changes in trends and pattern of strong opioid prescribing in primary care","volume":"18","author":"Zin","year":"2014","journal-title":"Eur J Pain"},{"key":"2022111921522783100_ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/annonc\/mdt504","article-title":"Next steps in access and availability of opioids for the treatment of cancer pain: reaching the tipping point?","volume":"24","author":"Cleary","year":"2013","journal-title":"Ann Oncol"},{"key":"2022111921522783100_ref3","volume-title":"Cancer Pain","author":"Scholten","year":"2013"},{"key":"2022111921522783100_ref4","doi-asserted-by":"crossref","first-page":"e010276","DOI":"10.1136\/bmjopen-2015-010276","article-title":"Prescribed opioids in primary care: cross-sectional and longitudinal analyses of influence of patient and practice characteristics","volume":"6","author":"Foy","year":"2016","journal-title":"BMJ Open"},{"key":"2022111921522783100_ref5","first-page":"41","article-title":"Prescription opioid usage and abuse relationships: an evaluation of state prescription drug monitoring program efficacy","volume":"3","author":"Reisman","year":"2009","journal-title":"Subst Abuse"},{"key":"2022111921522783100_ref6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.5694\/mja10.11450","article-title":"Prescription of opioid analgesics and related harms in Australia","volume":"195","author":"Roxburgh","year":"2011","journal-title":"Med J Aust"},{"key":"2022111921522783100_ref7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.36076\/ppj.2012\/15\/ES191","article-title":"Prescription opioid related misuse, harms, diversion and interventions in Canada: a review","volume":"15","author":"Fischer","year":"2012","journal-title":"Pain Physician"},{"key":"2022111921522783100_ref8","first-page":"45","article-title":"Increase in opiate prescription in Germany between 2000 and 2010: a study based on insurance data","volume":"110","author":"Schubert","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"2022111921522783100_ref9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jpainsymman.2003.05.002","article-title":"Cancer patients' share in a population's use of opioids. A linkage study between a prescription database and the Danish cancer registry","volume":"27","author":"Jarlbaek","year":"2004","journal-title":"J Pain Symptom Manage"},{"key":"2022111921522783100_ref10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/jjco\/hyy117","article-title":"End-of-life care for cancer patients in Japanese acute care hospitals: a nationwide retrospective administrative database survey","volume":"48","author":"Sato","year":"2018","journal-title":"Jpn J Clin Oncol"},{"key":"2022111921522783100_ref11","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1200\/JCO.2012.42.0919","article-title":"Opioid prescribing for cancer pain during the last 3 months of life: associated factors and 9-year trends in a nationwide United Kingdom cohort study","volume":"30","author":"Higginson","year":"2012","journal-title":"J Clin Oncol"},{"key":"2022111921522783100_ref12","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.je.2016.09.009","article-title":"Validity of diagnoses, procedures, and laboratory data in Japanese administrative data","volume":"27","author":"Yamana","year":"2017","journal-title":"J Epidemiol"},{"key":"2022111921522783100_ref13","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1200\/JCO.21.00476","article-title":"US trends in opioid access among patients with poor prognosis cancer near the end-of-life","volume":"39","author":"Enzinger","year":"2021","journal-title":"J Clin Oncol"},{"key":"2022111921522783100_ref14","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jpainsymman.2012.03.011","article-title":"Using a morphine equivalence metric to quantify opioid consumption: examining the capacity to provide effective treatment of debilitating pain at the global, regional, and country levels","volume":"45","author":"Gilson","year":"2013","journal-title":"J Pain Symptom Manage"},{"key":"2022111921522783100_ref15","article-title":"EEssential medicines consumption for every country in the world","author":"Walther Global Palliative Care & Supportive Oncology"},{"key":"2022111921522783100_ref16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jpainsymman.2006.05.015","article-title":"Opioid escalation in patients with cancer pain: the effect of age","volume":"32","author":"Mercadante","year":"2006","journal-title":"J Pain Symptom Manage"},{"key":"2022111921522783100_ref17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s11912-019-0854-7","article-title":"Managing pain in the older cancer patient","volume":"21","author":"Finnerty","year":"2019","journal-title":"Curr Oncol Rep"},{"key":"2022111921522783100_ref18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1067\/mgn.2000.108267","article-title":"Cancer pain management in the elderly","volume":"21","author":"Maxwell","year":"2000","journal-title":"Geriatr Nurs"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/52\/11\/1297\/47141103\/hyac122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/52\/11\/1297\/47141103\/hyac122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T21:54:17Z","timestamp":1668894857000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/52\/11\/1297\/6652300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,30]]},"references-count":18,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,7,30]]},"published-print":{"date-parts":[[2022,11,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyac122","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11]]},"published":{"date-parts":[[2022,7,30]]}}}