{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T04:57:14Z","timestamp":1763182634517,"version":"3.41.2"},"reference-count":22,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21fk0108098"],"award-info":[{"award-number":["JP21fk0108098"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although geographical differences in the distribution of human papillomavirus genotypes have been observed worldwide, no studies have reported on national differences in the prevalence of human papillomavirus types in Japan. Here, we report a cross-sectional study to explore regional differences in the prevalence of human papillomavirus types among Japanese women with cervical intraepithelial neoplasia or invasive cervical cancer. Using human papillomavirus genotyping data from the nationwide prospective study on human papillomavirus vaccine effectiveness, we compared the frequency of detection of 15 high-risk and two low-risk human papillomavirus types in each disease category between the women who visited hospitals located in eastern Japan and those who visited hospitals located in western Japan. The risk of cervical intraepithelial neoplasia progression was assessed by calculating a prevalence ratio of each human papillomavirus type for cervical intraepithelial neoplasia grade 2\/3 versus grade 1. Among the human papillomavirus types studied, human papillomavirus 52 was detected significantly more frequently in western hospitals than in eastern hospitals in cervical intraepithelial neoplasia grade 1 patients, but was less frequent in cervical intraepithelial neoplasia grade 2\/3. The prevalence of particular human papillomavirus types was not significantly different between patients in hospitals in eastern Japan and those in hospitals in western Japan for invasive cervical cancer. In both eastern and western hospitals, a higher risk of cervical intraepithelial neoplasia progression was observed in patients infected with human papillomavirus 16, 31 or 58. In contrast, there was a significantly higher prevalence of human papillomavirus 52 infection in women with cervical intraepithelial neoplasia grade 2\/3 than in those with cervical intraepithelial neoplasia grade 1 in eastern hospitals (prevalence ratio, 1.93; 95% confidence interval, 1.48\u20132.58), but not in western hospitals (prevalence ratio, 1.03; 95% confidence interval, 0.83\u20131.30). Regional differences of human papillomavirus 52 prevalence in cervical intraepithelial neoplasia lesions may exist and emphasize the importance of continuous monitoring of human papillomavirus type prevalence throughout the country in order to accurately assess the efficacy of human papillomavirus vaccines.<\/jats:p>","DOI":"10.1093\/jjco\/hyac127","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T09:48:15Z","timestamp":1659952095000},"source":"Crossref","is-referenced-by-count":1,"title":["Regional differences in human papillomavirus type 52 prevalence among Japanese women with cervical intraepithelial neoplasia"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9080-1642","authenticated-orcid":false,"given":"Iwao","family":"Kukimoto","sequence":"first","affiliation":[{"name":"Pathogen Genomics Center, National Institute of Infectious Diseases , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamiko","family":"Onuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Showa University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Hyogo Cancer Center , Akashi , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-8993","authenticated-orcid":false,"given":"Hideaki","family":"Yahata","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics , Graduate School of Medical Sciences, , Fukuoka , Japan"},{"name":"Kyushu University , Graduate School of Medical Sciences, , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Cancer Institute Hospital , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harushige","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Saitama Cancer Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Konnai","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Kanagawa Cancer Center , Kanagawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Nio","sequence":"additional","affiliation":[{"name":"Gynecology Service, NHO Kyushu Cancer Center , Fukuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Takehara","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, National Hospital Organization Shikoku Cancer Center , Matsuyama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kamiura","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Osaka International Cancer Institute , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotake","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kurume University School of Medicine , Kurume , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Jichi Medical University , Tochigi , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneaki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine , Sendai , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekatsu","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine , Osaka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Saitama Medical University International Medical Center , Saitama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Motohara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Faculty of Life Sciences, , Kumamoto , Japan"},{"name":"Kumamoto University , Faculty of Life Sciences, , Kumamoto , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Faculty of Medicine, , Sapporo , Japan"},{"name":"Hokkaido University Graduate School of Medicine , Faculty of Medicine, , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Dentistry and Pharmaceutical Sciences, , Okayama , Japan"},{"name":"Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences, , Okayama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Okunomiya","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine , Kyoto , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Tasaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Faculty of Medicine, , Tsukuba , Japan"},{"name":"University of Tsukuba , Faculty of Medicine, , Tsukuba , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology, National Cancer Center Hospital , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Hirashima","sequence":"additional","affiliation":[{"name":"Division of Gynecology, Shizuoka Cancer Center Hospital , Shizuoka , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Shimoji","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Graduate School of Medicine, , Okinawa , Japan"},{"name":"University of the Ryukyus , Graduate School of Medicine, , Okinawa , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuyo","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Graduate School of Medicine, , Tokyo , 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Yaegashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine , Sendai , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Showa University School of Medicine , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"MINT Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,6]]},"reference":[{"key":"2022080809480660700_ref1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/rmv.1822","article-title":"Human papillomavirus molecular biology and disease association","volume":"25","author":"Doorbar","year":"2015","journal-title":"Rev Med 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