{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:41:36Z","timestamp":1784997696127,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K17987"],"award-info":[{"award-number":["JP19K17987"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>the advent of BRAF inhibitors for preoperative treatment of craniopharyngioma has necessitated the identification of BRAFV600E status. Hence, we investigated predictors of BRAFV600E mutation in craniopharyngiomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>this retrospective study utilized data from 30 patients who were newly diagnosed with craniopharyngioma between 2011 and 2021. Magnetic resonance imaging (MRI) and computed tomography were performed within 1 week prior to surgery. Genetic analysis for BRAF mutation was performed using the Oncomine next-generation sequencing panel or Sanger sequencing. The relationship between BRAF mutation and demographic data, endocrinological function and tumour characteristics on imaging was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>tumour tissue carried the BRAFV600E mutation in nine patients. There was no significant difference in age, sex, or presence of hormonal dysfunction amongst patients with and without the BRAFV600E mutation in the tumour. Most tumours with the BRAFV600E mutation were histologically categorized as papillary craniopharyngioma (P\u00a0=\u00a00.0005), and were solid (P\u00a0=\u00a00.0002) and supra-diaphragmatic (P\u00a0=\u00a00.0033) on MRI. BRAFV600E tumours were more frequently associated with optic tract edema than wild-type tumour s (55.6 vs. 0%, P\u00a0=\u00a00.0009) and all tumour s with optic tract edema carried the BRAFV600E mutation. Optic tract edema was not associated with tumour volume, cysts, or preoperative pituitary function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>in craniopharyngiomas, the presence of optic tract edema can predict the presence of BRAFV600E mutation with a positive predictive value of 100%. The finding should be verified in larger prospective cohorts and multivariate regression analysis.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jjco\/hyad003","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T12:57:57Z","timestamp":1674478677000},"page":"378-385","source":"Crossref","is-referenced-by-count":3,"title":["Optic tract edema in craniopharyngioma as a predictor of BRAFV600E mutation presence"],"prefix":"10.1093","volume":"53","author":[{"given":"Akira","family":"Taguchi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Biomedical and Health Science, , Hiroshima , Japan"},{"name":"Hiroshima University , Graduate School of Biomedical and Health Science, , Hiroshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Biomedical and Health Science, , Hiroshima , Japan"},{"name":"Hiroshima University , Graduate School of Biomedical and Health Science, , Hiroshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kojima","sequence":"additional","affiliation":[{"name":"Natural Science Center for Basic Research and Development (N-BARD), Hiroshima University , Hiroshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwa J","family":"Amatya","sequence":"additional","affiliation":[{"name":"Department of Pathology , Graduate School of Biomedical and Health Sciences, , Hiroshima , Japan"},{"name":"Hiroshima University , Graduate School of Biomedical and Health Sciences, , Hiroshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neuro-Endovascular Therapy, Hiroshima Prefectural Hospital , Hiroshima , 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