{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:01:36Z","timestamp":1782964896515,"version":"3.54.5"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100020685","name":"Japan Hospice Palliative Care Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020685","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H05212"],"award-info":[{"award-number":["JP16H05212"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Cultural, social, and legal factors have been known to affect physicians\u2019 practice of continuous deep sedation. There have been few quantitative studies to compare continuous deep sedation practice in Asian countries. We aimed to describe and compare clinical characteristics of continuous deep sedation in Japan, Korea and Taiwan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with advanced cancer admitted to participating palliative care units were enrolled from January 2017 to September 2018. We evaluated and compared (i) the prevalence of continuous deep sedation, (ii) the characteristics of sedated and non-sedated groups in each country, and (iii) continuous deep sedation administration patterns among the three countries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2158 participants were included in our analysis, and 264 received continuous deep sedation. The continuous deep sedation prevalence was 10, 16 and 22% in Japan, Korea and Taiwan, respectively. Delirium was the most frequent target symptom in all countries, along with dyspnoea (in Japan) and psychological symptoms (in Korea). Midazolam was most frequently used in Japan and Taiwan, but not in Korea (P &amp;lt; 0.001). Among the patients receiving continuous deep sedation, the hydration amount on the final day was significantly different, with median volumes of 200, 500 and 0 mL in Japan, Korea and Taiwan, respectively (P &amp;lt; 0.001). In Korea, 33% of the continuous deep sedation administration caused a high degree of physicians\u2019 discomfort, but 3% in Japan and 5% in Taiwan (P &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Clinical practices of continuous deep sedation and physicians\u2019 discomfort related to continuous deep sedation initiation highly varied across countries. We need to develop optimal decision-making models of continuous deep sedation and hydration during continuous deep sedation in each country.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyad037","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T13:02:21Z","timestamp":1682686941000},"page":"714-721","source":"Crossref","is-referenced-by-count":6,"title":["Cross-cultural comparison of continuous deep sedation for advanced cancer patients in East Asian countries: prospective cohort study"],"prefix":"10.1093","volume":"53","author":[{"given":"Chiu-Hsien","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University , Kaohsiung , Taiwan"},{"name":"Marie Curie Palliative Care Research Department, Division of Psychiatry, University College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Palliative and Supportive Care, Seirei Mikatahara General Hospital , Hamamatsu , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Morita","sequence":"additional","affiliation":[{"name":"Division of Palliative and Supportive Care, Seirei Mikatahara General Hospital , Hamamatsu , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, College of Medicine and Hospital, National Taiwan University , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Yeon","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Dongguk University Ilsan Hospital , Goyang-si , South Korea"},{"name":"Department of Medicine, Dongguk University Medical School , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, School of Medicine, Catholic Kwandong University, International St. Mary\u2019s Hospital , Incheon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naosuke","family":"Yokomichi","sequence":"additional","affiliation":[{"name":"Division of Palliative and Supportive Care, Seirei Mikatahara General Hospital , Hamamatsu , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Imai","sequence":"additional","affiliation":[{"name":"Seirei Hospice, Seirei Mikatahara General Hospital, Hamamatsu , Shizuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Ito","sequence":"additional","affiliation":[{"name":"Hospice, The Japan Baptist Hospital , Kyoto , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Palliative Medicine, Kobe University Graduate School of Medicine , Kobe , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Hiratsuka","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Tohoku University School of Medicine , Sendai , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Tsuneto","sequence":"additional","affiliation":[{"name":"Department of Human Health Sciences, Graduate School of Medicine, Kyoto University , Kyoto , 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