{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:32:45Z","timestamp":1784205165083,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To understand the real-world outcomes for patients with penile cancer in the Kyushu\u2013Okinawa area before the introduction of practice guidelines in Japan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively collected medical information on patients with penile squamous cell carcinoma and penile intraepithelial neoplasia at 12 university hospitals and their affiliated hospitals in the Kyushu\u2013Okinawa area from January 2009 to December 2020. Patients with unknown clinical stage were excluded. Patient background characteristics and survival, as well as pretreatment factors involved in survival, were investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 196 patients were included. Patients with clinical stage 0, I, IIA, IIB, IIIA, IIIB and IV comprised 9.7, 26.0, 22.4, 2.6, 10.7, 14.3 and 14.3%, respectively. The median follow-up was 26\u00a0months, and the mean 5-year overall survival and cancer-specific survival rates were 74.3 and 79.8%, respectively. On univariate analysis, tumor diameter\u00a0\u2265\u00a030\u00a0mm, penile shaft tumor, Eastern Cooperative Oncology Group performance status\u00a0\u2265\u00a01, cT\u00a0\u2265\u00a03, cN\u00a0\u2265\u00a02 and cM1 were associated with significantly poorer cancer-specific survival. On multivariate analysis, pretreatment factors of cN\u00a0\u2265\u00a02 (hazard ratio, 32.5; 95% confidence interval, 5.08\u2013208; P\u00a0=\u00a00.0002), Eastern Cooperative Oncology Group performance status\u00a0\u2265\u00a01 (4.42; 1.79\u201310.9; P\u00a0=\u00a00.0012) and cT\u00a0\u2265\u00a03 (3.34; 1.11\u201310.1; P\u00a0=\u00a00.0319) were identified as independent prognostic factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The study revealed basic data for future penile cancer treatment and research, including survival rates according to clinical stages, and identified cN\u00a0\u2265\u00a02, Eastern Cooperative Oncology Group performance status\u00a0\u2265\u00a01 and cT\u00a0\u2265\u00a03 at initial diagnosis as independent prognostic factors. Evidence for penile cancer in Japan is particularly scarce, and future large-scale prospective studies are warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyad053","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:18:15Z","timestamp":1686183495000},"page":"837-844","source":"Crossref","is-referenced-by-count":5,"title":["Real-world treatment outcomes of patients with penile cancer in the Kyushu\u2013Okinawa area of Japan in the pre-guideline era"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-7305","authenticated-orcid":false,"given":"Takahiro","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Urology , Faculty of Life Sciences, , Kumamoto, Kumamoto , Japan"},{"name":"Kumamoto University , Faculty of Life Sciences, , Kumamoto, Kumamoto , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Goya","sequence":"additional","affiliation":[{"name":"Department of Urology, Chubu Tokushukai Hospital , Kitanakagusuku, Okinawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Higashijima","sequence":"additional","affiliation":[{"name":"Department of Urology , School of Medicine, , Kitakyushu, Fukuoka , Japan"},{"name":"University of Occupational and Environmental Health , School of Medicine, , Kitakyushu, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Tobu","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Saga, Saga , Japan"},{"name":"Saga University , Faculty of Medicine, , Saga, Saga , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Yufu, Oita , Japan"},{"name":"Oita University , Faculty of Medicine, , Yufu, Oita , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Tatarano","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Kagoshima, Kagoshima , Japan"},{"name":"Kagoshima University , Faculty of Medicine, , Kagoshima, Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Miyazaki, Miyazaki , Japan"},{"name":"University of Miyazaki , Faculty of Medicine, , Miyazaki, Miyazaki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei-ichiro","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Urology, Kurume University School of Medicine , Kurume, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Tatsugami","sequence":"additional","affiliation":[{"name":"Department of Urology, Kitakyushu Municipal Medical Center , Kitakyushu, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuna","family":"Tsubouchi","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Fukuoka, Fukuoka , Japan"},{"name":"Fukuoka University , Faculty of Medicine, , Fukuoka, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Shida","sequence":"additional","affiliation":[{"name":"Department of Urology, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki, Nagasaki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsu","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Urology, Fukuoka University Chikushi Hospital , Chikushino, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Urology, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki, Nagasaki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Fukuoka, Fukuoka , Japan"},{"name":"Fukuoka University , Faculty of Medicine, , Fukuoka, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Fukuoka, Fukuoka , Japan"},{"name":"Fukuoka University , Faculty of Medicine, , Fukuoka, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Urology , Graduate School of Medical Sciences, , Fukuoka, Fukuoka , Japan"},{"name":"Kyushu University , Graduate School of Medical Sciences, , Fukuoka, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Igawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Kurume University School of Medicine , Kurume, Fukuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kamoto","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Miyazaki, Miyazaki , Japan"},{"name":"University of Miyazaki , Faculty of Medicine, , Miyazaki, Miyazaki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Enokida","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Kagoshima, Kagoshima , Japan"},{"name":"Kagoshima University , Faculty of Medicine, , Kagoshima, Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Yufu, Oita , Japan"},{"name":"Oita University , Faculty of Medicine, , Yufu, Oita , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Urology , Faculty of Medicine, , Saga, Saga , Japan"},{"name":"Saga University , Faculty of Medicine, , Saga, Saga , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Urology , School of Medicine, , Kitakyushu, Fukuoka , Japan"},{"name":"University of Occupational and Environmental Health , School of Medicine, , Kitakyushu, Fukuoka , 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