{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:23:47Z","timestamp":1789597427233,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pain and post-operative nausea and vomiting are the main factors that impair the quality of recovery after surgery. Very few reports have analyzed patient-reported outcomes to investigate the efficacy of an enhanced recovery after surgery protocol to alleviate these symptoms after head and neck surgeries with free tissue transfer reconstruction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We investigated post-operative pain and post-operative nausea and vomiting in 47 patients who underwent head and neck surgeries with free tissue transfer reconstruction with enhanced recovery after surgery support between February 2021 and August 2022. Patient-reported outcomes were assessed using the visual analog scale and Japanese version of the Quality of Recovery-40.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Significant increases in the mean visual analog scale scores for pain and post-operative nausea and vomiting were observed only on post-operative Day 1 compared with preoperative values (pain: 3.19\u00a0\u00b1\u00a02.78 vs. 1.96\u00a0\u00b1\u00a02.42, P\u00a0=\u00a00.0408; post-operative nausea and vomiting: 1.52\u00a0\u00b1\u00a02.09 vs. 0.54\u00a0\u00b1\u00a01.37, P\u00a0=\u00a00.0194). From post-operative Day 2, there were no significant differences between the pre- and post-operative visual analog scale scores, and no significant increases in the incidences of moderate or severe pain and post-operative nausea and vomiting compared with preoperatively. The Japanese version of the Quality of Recovery-40 score for post-operative pain showed no significant deterioration compared with preoperatively, while the Japanese version of the Quality of Recovery-40 score for post-operative nausea and vomiting showed significant deterioration compared with the preoperative value on post-operative Days 2, 4 and 7.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The visual analog scale and Japanese version of the Quality of Recovery-40 scores for post-operative pain and visual analog scale score for post-operative nausea and vomiting suggested that the enhanced recovery after surgery strategy favorably controlled pain and post-operative nausea and vomiting after head and neck surgeries with free tissue transfer reconstruction. However, as the post-operative Japanese version of the Quality of Recovery-40 score for post-operative nausea and vomiting was lower than the preoperative value, there is still a need for further improvement of the enhanced recovery after surgery pathway.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyad094","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T09:04:29Z","timestamp":1691053469000},"page":"1038-1044","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of an enhanced recovery after surgery pathway to manage pain, nausea and vomiting after head and neck surgeries with free tissue transfer reconstruction"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9016-656X","authenticated-orcid":false,"given":"Takayuki","family":"Imai","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiko","family":"Takasago","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Momma","sequence":"additional","affiliation":[{"name":"Department of Nursing, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyo","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Nursing, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Nakanome","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinkichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohsei","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Medical Oncology, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Miyagi Cancer Center , Natori, Miyagi , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"2023110906364145300_ref1","doi-asserted-by":"crossref","first-page":"i27","DOI":"10.1093\/bja\/aer358","article-title":"Multimodal therapies for postoperative nausea and vomiting, and pain","volume":"107","author":"Chandrakantan","year":"2011","journal-title":"Br J Anaesth"},{"key":"2023110906364145300_ref2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00000542-199907000-00018","article-title":"Can postoperative nausea and vomiting be 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meta-analysis","volume":"24","author":"Wang","year":"2018","journal-title":"World J Gastroenterol"},{"key":"2023110906364145300_ref6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jmig.2018.12.010","article-title":"Enhanced recovery after surgery in gynecology: a review of the literature","volume":"26","author":"Scheib","year":"2019","journal-title":"J Minim Invasive Gynecol"},{"key":"2023110906364145300_ref7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s40064-016-1793-5","article-title":"The enhanced recovery after surgery (ERAS) program in liver surgery: a meta-analysis of randomized controlled trials","volume":"5","author":"Song","year":"2016","journal-title":"Springerplus"},{"key":"2023110906364145300_ref8","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.3748\/wjg.v24.i15.1666","article-title":"Impact of enhanced recovery after surgery programs on pancreatic surgery: a 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