{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:33:46Z","timestamp":1740130426332,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It has been shown that a group of rectal cancer patients will achieve a pathological complete response following preoperative chemoradiotherapy, and non-operative management has recently gained attention. To escalate the tumour dose and increase the likelihood of pathological complete response, brachytherapy can play an important role in safely increasing the total dose. However, at the time this report was published, an applicator dedicated to rectal brachytherapy was unaffordable in Japan. Here, we report two T3 rectal cancer patients who were inoperable or refused surgery and treated by chemoradiotherapy following intracavitary brachytherapy involving a vaginal cylinder applicator with lead shielding.<\/jats:p>","DOI":"10.1093\/jjco\/hyad099","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T07:17:36Z","timestamp":1691565456000},"page":"1082-1086","source":"Crossref","is-referenced-by-count":0,"title":["Non-operative management involving chemoradiation therapy combined with high-dose-rate brachytherapy for T3 rectal cancer using a vaginal shielded cylindrical applicator: a technical report"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0660-9987","authenticated-orcid":false,"given":"Naoya","family":"Murakami","sequence":"first","affiliation":[{"name":"Juntendo University Department of Radiation Oncology, , Tokyo , Japan"},{"name":"National Cancer Center Hospital Department of Radiation Oncology, , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Kojima","sequence":"additional","affiliation":[{"name":"Juntendo University Department of Radiation Oncology, , Tokyo , Japan"},{"name":"National Cancer Center Hospital Department of Radiation Oncology, , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kae","family":"Okuma","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital Department of Radiation Oncology, , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tairo","family":"Kashihara","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital Department of Radiation Oncology, , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital Radiation Safety and Quality Assurance Division, , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakako","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Kimitsu Chuo Hospital Department of Radiation Oncology, , Chiba , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichiro","family":"Suda","sequence":"additional","affiliation":[{"name":"Kimitsu Chuo Hospital Department of Surgery, , Chiba , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7817-624X","authenticated-orcid":false,"given":"Hiroshi","family":"Igaki","sequence":"additional","affiliation":[{"name":"National Cancer Center Hospital Department of Radiation Oncology, , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Shikama","sequence":"additional","affiliation":[{"name":"Juntendo University Department of Radiation Oncology, , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"2023110906363430100_ref1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1056\/NEJMoa060829","article-title":"Chemotherapy with preoperative radiotherapy in rectal cancer","volume":"355","author":"Bosset","year":"2006","journal-title":"N Engl J Med"},{"key":"2023110906363430100_ref2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S1470-2045(10)70172-8","article-title":"Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data","volume":"11","author":"Maas","year":"2010","journal-title":"Lancet Oncol"},{"key":"2023110906363430100_ref3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41571-021-00538-5","article-title":"International consensus recommendations on key outcome measures for organ preservation 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