{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:35:26Z","timestamp":1760524526829,"version":"3.37.3"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Selective mediastinal lymph node dissection based on lobe-specific metastases is widely recognized in daily practice. However, the significance of mediastinal lymph node dissection for N1-positive tumors has not been elucidated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively reviewed 359 patients with N1-positive lung cancer who underwent lobectomy with systematic mediastinal lymph node dissection (systematic lymph node dissection) (n\u00a0=\u00a0150) and lobe-specific mediastinal lymph node dissection (lobe-specific lymph node dissection) (n\u00a0=\u00a0209). The operative and postoperative results and their propensity score-matched pairs were compared. The factors affecting survival were assessed using competing risk and multivariable analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The cumulative incidence of recurrence and the cumulative incidence of cancer-specific death were not significantly different between systematic and lobe-specific lymph node dissection in entire cohort. In the propensity score-matched cohort (83 pairs), systematic lymph node dissection tended to detect N2 lymph node metastasis more frequently (55.4 vs. 41%, P\u00a0=\u00a00.087). Eleven patients (13.2%) in the systematic lymph node dissection group had a metastatic N2 lymph node \u2018in the systematic lymph node dissection field\u2019 that lobe-specific lymph node dissection did not dissect. The oncological outcomes between patients undergoing systematic lymph node dissection (5-year cumulative incidence of recurrence, 62.1%; 5-year cumulative incidence of cancer-specific death, 27.9%) and lobe-specific lymph node dissection (5-year cumulative incidence of recurrence, 60.1%; 5-year cumulative incidence of cancer-specific death, 23.3%) were similar. The propensity score-adjusted multivariable analysis for cumulative incidence of recurrence revealed that the prognosis associated with systematic lymph node dissection was comparable with the prognosis with lobe-specific lymph node dissection (hazard ratio, 1.17; 95% confidence interval, 0.82\u20131.67; P\u00a0=\u00a00.37).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The extent of lymph node dissection can affect accurate pathological staging; however, it was not associated with survival outcome in the treatment of N1-positive lung cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyad110","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T11:32:01Z","timestamp":1692963121000},"page":"1183-1190","source":"Crossref","is-referenced-by-count":2,"title":["A multicenter propensity score-matched analysis of lymphadenectomy in N1-positve lung cancer"],"prefix":"10.1093","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4890-2019","authenticated-orcid":false,"given":"Yoshinori","family":"Handa","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-1027","authenticated-orcid":false,"given":"Yasuhiro","family":"Tsutani","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8928","authenticated-orcid":false,"given":"Takahiro","family":"Mimae","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanagawa Cancer Center , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Medical University , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanagawa Cancer Center , Yokohama , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Medical University , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-3828","authenticated-orcid":false,"given":"Morihito","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"2023120714400718200_ref1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0003-4975(10)64717-0","article-title":"The importance of surgery to nonsmall cell carcinoma of the lung with mediastinal lymph node metastasis","volume":"46","author":"Naruke","year":"1988","journal-title":"Ann Thorac 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The memorial experience","volume":"5","author":"Martini","year":"1995","journal-title":"Chest Surg Clin N Am"},{"key":"2023120714400718200_ref12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/jjco\/hyx170","article-title":"A randomized Phase III trial of lobespecific vs. systematic nodal dissection for clinical Stage I-II non-small cell lung cancer (JCOG1413)","volume":"48","author":"Hishida","year":"2018","journal-title":"Jpn J Clin Oncol"},{"key":"2023120714400718200_ref13","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1056\/NEJM198506203122504","article-title":"The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer","volume":"312","author":"Feinstein","year":"1985","journal-title":"N Engl J Med"},{"author":"National Comprehensive Cancer Network","key":"2023120714400718200_ref14"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/53\/12\/1183\/54060660\/hyad110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/53\/12\/1183\/54060660\/hyad110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T17:30:05Z","timestamp":1701970205000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/53\/12\/1183\/7250139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":14,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,8,24]]},"published-print":{"date-parts":[[2023,12,7]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyad110","relation":{},"ISSN":["1465-3621"],"issn-type":[{"type":"electronic","value":"1465-3621"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,8,24]]}}}