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Risk factors include exposure to ultraviolet light, fair skin, radiation and human papillomavirus infection. The standard treatment is surgical removal, and in cases of orbital invasion, orbital content removal is required. If sentinel node biopsy reveals a high risk of lymph node metastasis, adjuvant radiotherapy may be considered. Local chemotherapy, such as imiquimod and 5-fluorouracil, may be used for eyelid squamous cell carcinoma in situ. When surgery or radiotherapy is not recommended for distant metastases or locally advanced disease, drug therapy is often according to head and neck squamous cell carcinoma in Japan. The treatment often requires a multidisciplinary team to ensure the preservation of function and cosmetic appearance.<\/jats:p>","DOI":"10.1093\/jjco\/hyad127","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T14:27:25Z","timestamp":1695652045000},"page":"4-12","source":"Crossref","is-referenced-by-count":19,"title":["Squamous cell carcinoma of the eyelid"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4145-8694","authenticated-orcid":false,"given":"Yasuyoshi","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research , Tokyo , Japan"},{"name":"Department of Chemotherapy and Cancer Center, The University of Tokyo Hospital , Tokyo , 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