{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:27:52Z","timestamp":1771079272188,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In 2021, the International Germ Cell Cancer Collaborative Group (IGCCCG) Update Consortium reported improved overall survival (OS) rates in a modern cohort of metastatic non-seminoma testis cancer patients within each of the IGCCCG prognosis groups (96% in good vs. 89% in intermediate vs. 67% in poor), compared to the previous IGCCCG publication (92% in good vs. 80% in intermediate vs. 48% in poor). We hypothesized that a similar survival improvement may apply to a contemporary North-American population-based cohort of non-seminoma testis cancer patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and Methods<\/jats:title>\n                  <jats:p>The Surveillance, Epidemiology, and End Results (SEER) database (2010\u20132018) was used. Kaplan\u2013Meier plots and multivariable Cox regression models tested the effect of IGCCCG prognosis groups on overall mortality (OM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 1672 surgically treated metastatic non-seminoma patients, 778 (47%) exhibited good vs. 251 (15%) intermediate vs. 643 (38%) poor prognosis. In the overall cohort, five-year OS rate was 94% for good prognosis vs. 87% for intermediate prognosis vs. 65% for poor prognosis. In multivariable Cox regression models predicting OM, intermediate (Hazard ratio [HR] 2.4, 95% confidence interval [CI] 1.4\u20133.9, P\u00a0&amp;lt;\u00a00.001) and poor prognosis group (HR 6.6, 95% CI 1.0\u20131.0, P\u00a0&amp;lt;\u00a00.001) were independent predictors of higher OM, relative to good prognosis group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The survival improvement reported by the IGCCCG Update Consortium is also operational in non-seminoma testis cancer patients within the most contemporary SEER database. This observation indicates that the survival improvement is not only applicable to centres of excellence, but also applies to other institutions at large.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyae011","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T03:20:41Z","timestamp":1708312841000},"page":"592-598","source":"Crossref","is-referenced-by-count":5,"title":["A population-based validation of the IGCCCG Update Consortium for survival in metastatic non-seminoma testis cancer"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-2274","authenticated-orcid":false,"given":"Reha-Baris","family":"Incesu","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Morra","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"Department of Neurosciences , Reproductive Sciences and Odontostomatology, , Naples , Italy"},{"name":"University of Naples Federico II , Reproductive Sciences and Odontostomatology, , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Scheipner","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"Department of Urology, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Barletta","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"Unit of Urology\/Division of Oncology , Gianfranco Soldera Prostate Cancer Lab, , Milan, Italy; Vita-Salute San Raffaele University, Milan , Italy"},{"name":"IRCCS San Raffaele Scientific Institute , Gianfranco Soldera Prostate Cancer Lab, , Milan, Italy; Vita-Salute San Raffaele University, Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Baudo","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"Department of Urology , IRCCS Ospedale Galeazzi\u2014Sant'Ambrogio, Milan, Italy; Department of Urology, , Milan , Italy"},{"name":"IRCCS Policlinico San Donato , IRCCS Ospedale Galeazzi\u2014Sant'Ambrogio, Milan, Italy; Department of Urology, , Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Cano","family":"Garcia","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"Department of Urology , University Hospital Frankfurt, , Frankfurt am Main , Germany"},{"name":"Goethe University Frankfurt am Main , University Hospital Frankfurt, , Frankfurt am Main , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Tappero","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"Department of Urology, IRCCS Policlinico San Martino , Genova , Italy"},{"name":"Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova , Genova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia Luca","family":"Piccinelli","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"Department of Urology, IEO European Institute of Oncology, IRCCS , Via Ripamonti 435, Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"},{"name":"University of Montr\u00e9al Health Center , Division of Urology, , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh F","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology , Comprehensive Cancer Center, , Vienna , Austria"},{"name":"Medical University of Vienna , Comprehensive Cancer Center, , Vienna , Austria"},{"name":"Department of Urology, Weill Cornell Medical College , New York, New York , USA"},{"name":"Department of Urology, University of Texas Southwestern Medical Center , Dallas, TX , USA"},{"name":"Hourani Center of Applied Scientific Research, Al-Ahliyya Amman University , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ottavio","family":"de Cobelli","sequence":"additional","affiliation":[{"name":"Department of Urology, IEO European Institute of Oncology, IRCCS , Via Ripamonti 435, Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Terrone","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS Policlinico San Martino , Genova , Italy"},{"name":"Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova , Genova , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix K H","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Urology , University Hospital Frankfurt, , Frankfurt am Main , Germany"},{"name":"Goethe University Frankfurt am Main , University Hospital Frankfurt, , Frankfurt am Main , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Carmignani","sequence":"additional","affiliation":[{"name":"Department of Urology , IRCCS Ospedale Galeazzi\u2014Sant'Ambrogio, Milan, Italy; Department of Urology, , Milan , Italy"},{"name":"IRCCS Policlinico San Donato , IRCCS Ospedale Galeazzi\u2014Sant'Ambrogio, Milan, Italy; Department of Urology, , Milan , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Oncology , Gianfranco Soldera Prostate Cancer Lab, , Milan, Italy; Vita-Salute San Raffaele University, Milan , Italy"},{"name":"IRCCS San Raffaele Scientific 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