{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:42:24Z","timestamp":1774374144342,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pancreatic cancer has a high risk of developing osteoporosis. However, the impact of osteoporosis has not been well-studied. This study aimed to evaluate bone loss over time and risk of osteoporosis in patients with advanced pancreatic cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively examined consecutive patients with unresectable pancreatic cancer who had evaluable computed tomography before treatment and at 1-year follow-up. Bone mineral density at the first lumbar vertebra was measured on computed tomography, and osteoporosis was defined as bone mineral density &amp;lt;\u00a0135 Hounsfield units. The prevalence and risk factors for osteoporosis, changes in bone mineral density over time and incidence of bone fractures were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Three hundred eighty patients were included. Osteoporosis was associated with older age, female sex, low body mass index and poor performance status at baseline. A consistent decrease in bone mineral density was observed over time regardless of age, sex or disease status, resulting in an increase in the prevalence of osteoporosis over time (47% at baseline, 79% at 1\u00a0year, 88% at 2\u00a0years, 89% at 3\u00a0years, 95% at 4\u00a0years and 100% at 5\u00a0years). Changes in bone mineral density from baseline were greater in patients with locally-advanced pancreatic cancer, in those who received modified FOLFIRINOX or S-IROX for more than 3 months, and in those who received radiation therapy. Incident fractures developed in 45 patients (12%) during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Osteoporosis and osteoporotic fractures were highly prevalent in patients with advanced pancreatic cancer. This study highlights the importance of screening for osteoporosis in such patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyae028","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T18:53:58Z","timestamp":1709837638000},"page":"667-674","source":"Crossref","is-referenced-by-count":3,"title":["Bone loss over time and risk of osteoporosis in advanced pancreatic cancer"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-8166","authenticated-orcid":false,"given":"Tsuyoshi","family":"Takeda","sequence":"first","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Ishitsuka","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9746-6776","authenticated-orcid":false,"given":"Takaaki","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-5558","authenticated-orcid":false,"given":"Takafumi","family":"Mie","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Kasuga","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Ozaka","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Sasahira","sequence":"additional","affiliation":[{"name":"Department of Hepato-Biliary-Pancreatic Medicine , , Tokyo , Japan"},{"name":"Cancer Institute Hospital of Japanese Foundation for Cancer Research , , Tokyo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"2024060203002432600_ref1","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2147\/TCRM.S138000","article-title":"A comprehensive overview on osteoporosis and its risk factors","volume":"14","author":"Pouresmaeili","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"2024060203002432600_ref2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1177\/2050640620938987","article-title":"Pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy in patients with advanced pancreatic cancer: a 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