{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:28:08Z","timestamp":1770830888226,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study explored the impacts of peri-operative changes in the neutrophil-to-lymphocyte ratio (NLR) on the survival rate after radical nephroureterectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective analysis included a multicentric cohort of patients diagnosed with upper tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy from 2012 to 2021. We assessed the preoperative NLR, postoperative NLR, delta-NLR (difference between postoperative and preoperative NLRs), and NLR change (ratio of postoperative to preoperative NLR). Additionally, patients were categorized according to increases in their preoperative and\/or postoperative NLRs. Associations of survival with peri-operative changes in the NLR were investigated using Cox multivariate regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 488 patients were included in the study, with a median age of 73\u00a0years. Among the patients, 105 (21.5%) exhibited elevated preoperative and postoperative NLRs, 88 (18.0%) exhibited elevated preoperative NLR only, 53 (10.9%) exhibited elevated postoperative NLR only, and 242 (49.6%) exhibited normal NLRs. Multivariate analysis indicated significant negative correlations between both preoperative and postoperative increased NLRs and oncological outcomes, including nonurothelial tract recurrence-free survival and cancer-specific survival (hazard ratio [HR]: 1.65, P\u00a0=\u00a00.017; HR: 2.12, P\u00a0=\u00a00.014, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This is the first study to evaluate the association between peri-operative changes in the NLR and the outcomes of patients with UTUC who underwent radical nephroureterectomy. Patients with elevated NLRs at both time points experienced considerably worse outcomes. Further research should explore whether increases in the NLR during long-term follow-up could indicate impending disease recurrence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyae081","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T12:56:54Z","timestamp":1719406614000},"page":"1201-1207","source":"Crossref","is-referenced-by-count":2,"title":["Associations between early changes in the neutrophil-to-lymphocyte ratio after radical nephroureterectomy and treatment outcomes"],"prefix":"10.1093","volume":"54","author":[{"given":"Shun","family":"Saito","sequence":"first","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]},{"name":"Jikei University Kashiwa Hospital Department of Urology, , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetsugu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Yata","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyoshi","family":"Takamizawa","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Hara","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7799-669X","authenticated-orcid":false,"given":"Keiichiro","family":"Miyajima","sequence":"additional","affiliation":[{"name":"The 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Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhisa","family":"Koide","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibuki","family":"Sadakane","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahito","family":"Atsuta","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]},{"name":"Jikei University Kashiwa Hospital Department of Urology, , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Mori","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Imai","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotaro","family":"Kayano","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Murakami","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kojiro","family":"Tashiro","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]},{"name":"Jikei Katsushika Medical Center Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-4684","authenticated-orcid":false,"given":"Shunsuke","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yamada","sequence":"additional","affiliation":[{"name":"The Jikei University School of Medicine Department of Urology, , Tokyo,","place":["Japan"]},{"name":"Jikei Katsushika Medical Center Department of Urology, , 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