{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:33:36Z","timestamp":1740130416729,"version":"3.37.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Taxanes are effective chemotherapy drugs for breast cancer care, but adverse effects pose a significant challenge in cancer treatment. Taxane-induced fluid retention and lower-extremity edema are two of the important dose-limiting toxicity and result in decreased quality of life (QoL). However, there is no standard of care to alleviate the symptoms. We conducted a clinical study to assess the efficacy of short-term aroma lymphatic tressage therapy (ALTT) in reducing taxane-induced edema in breast cancer patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this phase 2 clinical trial, patients with edema of CTCAE grade 2 or higher were enrolled and conducted 8 sessions of ALTT. The primary endpoint was to determine the proportion of patients with a reduction in lower extremity circumference of 3% or more before and 6\u00a0weeks after starting ALTT. The change in QoL was assessed as the secondary endpoint using QoL questionnaires.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 37 breast cancer patients completed the protocol and were analyzed. The median sum of the 3-point circumference (thigh, calf, and ankle) was 230.8\u00a0cm (IQR 218\u2013243) in the baseline and 220.2\u00a0cm (IQR 212\u2013236) at the end of the study. The average decrease of circumference was 3.8%. About, 23 patients (62%) experienced a circumference decrease of 3% or more. An improvement in every scale of FACT-TAXANE and EORTC-QLQ-C30 was observed when comparing questionnaire results before and at the end of the intervention (P\u00a0&amp;lt;\u00a00.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Eight sessions of ALTT over 4\u00a0weeks were effective in reducing lower-extremity edema and resulted in improvement of QoL in patients with breast cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyae099","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T13:07:37Z","timestamp":1724072857000},"page":"1306-1313","source":"Crossref","is-referenced-by-count":0,"title":["The effect of aroma lymphatic tressage on taxane-induced lower-extremity edema in breast cancer patients"],"prefix":"10.1093","volume":"54","author":[{"given":"Yang Sun","family":"Ha","sequence":"first","affiliation":[{"name":"Graduate School of Integrative Medicine , CHA University, 355, Pangyo-ro, Bundanggu, Seongnam-si, Kyonggi-do 13488 ,","place":["Republic of Korea"]},{"name":"OTI Oncology Aesthetic Korea , Seongbukro 114, Seongbuk-gu, Seoul 02837 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hemato-Oncology , Department of Internal Medicine, Korea University College of Medicine, , Seoul 02841 ,","place":["South Korea"]},{"name":"Korea University Anam Hospital , Department of Internal Medicine, Korea University College of Medicine, , Seoul 02841 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Korea University College of Medicine , 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"You","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery , Department of General Surgery, , 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841 ,","place":["South Korea"]},{"name":"Korea University Anam Hospital , Department of General Surgery, , 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Pil","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery , Department of General Surgery, , 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841 ,","place":["South Korea"]},{"name":"Korea University Anam Hospital , Department of General Surgery, , 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841 ,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk Chan","family":"Hahm","sequence":"additional","affiliation":[{"name":"Graduate School of Integrative Medicine, CHA University , 355, Pangyo-ro, Bundanggu, Seongnam-si, Kyonggi-do 13488 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-7920","authenticated-orcid":false,"given":"Kyong Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Hemato-Oncology , Department of Internal Medicine, Korea University College of Medicine, Korea University Anam Hospital, Seoul 02841,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"2024121023185224000_ref1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1568009033481967","article-title":"Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action","volume":"3","author":"Abal","year":"2003","journal-title":"Curr Cancer Drug Targets"},{"key":"2024121023185224000_ref2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00520-002-0405-9","article-title":"Managing taxane toxicities","volume":"11","author":"Markman","year":"2003","journal-title":"Support Care Cancer"},{"key":"2024121023185224000_ref3","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1200\/JCO.2003.07.013","article-title":"Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: a southwest oncology group and Gynecologic oncology group trial","volume":"21","author":"Markman","year":"2003","journal-title":"J Clin Oncol"},{"key":"2024121023185224000_ref4","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1200\/JCO.1998.16.10.3426","article-title":"Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment","volume":"16","author":"Semb","year":"1998","journal-title":"J Clin Oncol"},{"key":"2024121023185224000_ref5","doi-asserted-by":"crossref","first-page":"19635","DOI":"10.1200\/jco.2007.25.18_suppl.19635","article-title":"Docetaxel and fluid retention: use of single-dose dexamethasone","volume":"25","author":"Montoya","year":"2007","journal-title":"J Clin Oncol"},{"key":"2024121023185224000_ref6","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1200\/JCO.1997.15.9.3149","article-title":"Corticosteroids significantly delay the onset of docetaxel-induced fluid retention: final results of a randomized study of the European Organization for Research and Treatment of cancer investigational drug branch for breast cancer","volume":"15","author":"Piccart","year":"1997","journal-title":"J Clin Oncol"},{"key":"2024121023185224000_ref7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1200\/JCO.1996.14.2.422","article-title":"Docetaxel in patients with metastatic breast cancer: a phase II study of the National Cancer Institute of Canada-clinical trials group","volume":"14","author":"Trudeau","year":"1996","journal-title":"J Clin Oncol"},{"key":"2024121023185224000_ref8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/j.1365-2133.2006.07419.x","article-title":"Oedema as a risk factor for multiple episodes of cellulitis\/erysipelas of the lower leg: a series with community follow-up","volume":"155","author":"Cox","year":"2006","journal-title":"Br J Dermatol"},{"key":"2024121023185224000_ref9","first-page":"31","article-title":"Effects of massage on pain intensity, analgesics and quality of life in patients with cancer pain: a pilot study of a randomized clinical trial conducted within hospice care delivery","volume":"15","author":"Wilkie","year":"2000","journal-title":"Hosp J"},{"key":"2024121023185224000_ref10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/acm.2007.7176","article-title":"Role of massage therapy in cancer care","volume":"14","author":"Russell","year":"2008","journal-title":"J Altern Complement Med"},{"key":"2024121023185224000_ref11","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1200\/JCO.2006.08.9987","article-title":"Effectiveness of aromatherapy massage in the management of anxiety and depression in patients with cancer: a multicenter randomized controlled trial","volume":"25","author":"Wilkinson","year":"2007","journal-title":"J Clin Oncol"},{"key":"2024121023185224000_ref12","doi-asserted-by":"crossref","first-page":"102167","DOI":"10.1016\/j.eujim.2022.102167","article-title":"Aroma lymphatic massage (aroma lymphatic tressage) for symptom relief in breast cancer patients with taxane acute pain syndrome: a randomized controlled crossover trial","volume":"54","author":"Ha","year":"2022","journal-title":"Eur J Integr Med"},{"author":"National Institutes of Health, National Cancer Institute.","key":"2024121023185224000_ref13"},{"key":"2024121023185224000_ref14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2648.2008.04712.x","article-title":"Massage for symptom relief in patients with cancer: systematic review","volume":"63","author":"Wilkinson","year":"2008","journal-title":"J Adv Nurs"},{"key":"2024121023185224000_ref15","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cncr.11578","article-title":"Measuring the side effects of taxane therapy in oncology: the functional assesment of cancer therapy-taxane (FACT-taxane)","volume":"98","author":"Cella","year":"2003","journal-title":"Cancer"},{"key":"2024121023185224000_ref16","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/0959-8049(95)00296-0","article-title":"The EORTC core quality of life questionnaire (QLQ-C30): validity and reliability when analysed with patients treated with palliative radiotherapy","volume":"31a","author":"Kaasa","year":"1995","journal-title":"Eur J Cancer"},{"key":"2024121023185224000_ref17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000336480","article-title":"Subjective and objective assessment of edema during adjuvant chemotherapy for breast cancer using taxane-containing regimens in a randomized controlled trial: the National Surgical Adjuvant Study of breast cancer 02","volume":"82","author":"Ohsumi","year":"2012","journal-title":"Oncology"},{"key":"2024121023185224000_ref18","first-page":"1","article-title":"Docetaxel causes lymphatic endothelial cell apoptosis and impairs lymphatic function and gene expression in vitro","volume":"7","author":"Wong","year":"2021","journal-title":"J Transl Sci"},{"key":"2024121023185224000_ref19","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ijrobp.2013.02.018","article-title":"A model to estimate the risk of breast cancer-related lymphedema: combinations of treatment-related factors of the number of dissected axillary nodes, adjuvant chemotherapy, and radiation therapy","volume":"86","author":"Kim","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2024121023185224000_ref20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10549-014-3137-x","article-title":"Treatment factors affecting breast cancer-related lymphedema after systemic chemotherapy and radiotherapy in stage II\/III breast cancer patients","volume":"148","author":"Jung","year":"2014","journal-title":"Breast Cancer Res Treat"},{"key":"2024121023185224000_ref21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s10549-015-3408-1","article-title":"Impact of adjuvant taxane-based chemotherapy on development of breast cancer-related lymphedema: results from a large prospective cohort","volume":"151","author":"Swaroop","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"2024121023185224000_ref22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/CAD.0000000000000468","article-title":"Association between adjuvant docetaxel-based chemotherapy and breast cancer-related lymphedema","volume":"28","author":"Zhu","year":"2017","journal-title":"Anticancer Drugs"},{"volume-title":"Modern Treatment for Lymphoedema","author":"Casley-Smith","key":"2024121023185224000_ref23"},{"key":"2024121023185224000_ref24","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1245\/s10434-006-9332-1","article-title":"Lymphedema therapy reduces the volume of edema and pain in patients with breast cancer","volume":"14","author":"Hamner","year":"2007","journal-title":"Ann Surg Oncol"},{"volume-title":"Mae Fah Luang University International Conference 2012","year":"2012","author":"Phromthong","key":"2024121023185224000_ref25"},{"key":"2024121023185224000_ref26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.physbeh.2018.01.004","article-title":"The anxiolytic effect of Juniperus virginiana L. essential oil and determination of its active constituents","volume":"189","author":"Zhang","year":"2018","journal-title":"Physiol Behav"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/54\/12\/1306\/60983214\/hyae099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/54\/12\/1306\/60983214\/hyae099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:19:30Z","timestamp":1733872770000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/54\/12\/1306\/7735404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":26,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,8,19]]},"published-print":{"date-parts":[[2024,12,7]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyae099","relation":{},"ISSN":["1465-3621"],"issn-type":[{"type":"electronic","value":"1465-3621"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,8,19]]}}}