{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:21:32Z","timestamp":1770992492687,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although pulmonary metastasectomy is a commonly-performed procedure, data are lacking on the feasibility and oncological efficacy of removal of pulmonary metastases from pancreatic cancer. In this study, we retrospectively compared features of pulmonary metastases from pancreatic cancer versus colorectal cancer (CRC, patients with CRC being common candidates for pulmonary metastasectomy) and outcomes of removing such metastases, with our aim being to identify specific features of the former.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data on removal of 182 pulmonary metastases (29 from pancreatic and 153 from CRC) performed from January 2013 to April 2024 were included in this analysis. Radio-pathological findings were compared between these groups. The study cohort comprised 139 pulmonary metastasectomies in 119 patients (24 with pancreatic cancer and 95 with CRC) in whom R0 resection was achieved and follow-up data were available.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Atypical radiological findings of pulmonary metastases, including polygonal-shape (P\u00a0&amp;lt;\u00a00.001), spiculae (P\u00a0&amp;lt;\u00a00.001), air bronchogram (P\u00a0=\u00a00.012), peripheral ground-glass opacities (P\u00a0&amp;lt;\u00a00.001), and pleural tags (P\u00a0&amp;lt;\u00a00.001) were present more frequently in metastases from pancreatic cancer than from CRC. Furthermore, pleural lavage cytology was more frequently positive in pulmonary metastases from pancreatic cancer than in those from CRC (P\u00a0&amp;lt;\u00a00.001). Disease-free survival was significantly shorter after the removal of metastases from pancreatic than from CRC (P\u00a0&amp;lt;\u00a00.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Some pulmonary metastases from pancreatic cancer have atypical radiological features. Surgical interventions for these may enable diagnosis. The prognosis is significantly poorer after removing metastases from pancreatic cancer than from CRC. The therapeutic significance of our findings requires further investigation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyae107","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T13:59:43Z","timestamp":1724853583000},"page":"1314-1320","source":"Crossref","is-referenced-by-count":1,"title":["Pulmonary metastases from pancreatic cancer have different clinico-radiological features compared with those from colorectal cancer"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-435X","authenticated-orcid":false,"given":"Takeshi","family":"Kawaguchi","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Taiji","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Hamaji","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuharu","family":"Hosono","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyoshi","family":"Sawabata","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Nara Medical University , Nara ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"2024121023185148000_ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2024121023185148000_ref2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jso.24623","article-title":"Current and future therapies for advanced pancreatic cancer","volume":"116","author":"Gupta","year":"2017","journal-title":"J Surg Oncol"},{"key":"2024121023185148000_ref3","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1038\/s41598-020-61487-0","article-title":"Surgery for synchronous and metachronous single-organ metastasis of pancreatic cancer: a SEER database analysis and systematic literature review","volume":"10","author":"Liu","year":"2020","journal-title":"Sci Rep"},{"key":"2024121023185148000_ref4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jhbp.1127","article-title":"Outcomes of lung metastasis from pancreatic cancer: a nationwide multicenter analysis","volume":"29","author":"Homma","year":"2022","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"2024121023185148000_ref5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s11748-020-01298-2","article-title":"Thoracic and cardiovascular surgeries in Japan during 2017","volume":"68","author":"Shimizu","year":"2020","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"2024121023185148000_ref6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.athoracsur.2018.10.028","article-title":"Expert consensus document on pulmonary metastasectomy","volume":"107","author":"Handy","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"2024121023185148000_ref7","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s11605-011-1605-8","article-title":"Pulmonary resection for isolated pancreatic adenocarcinoma metastasis: an analysis of outcomes and survival","volume":"15","author":"Arnaoutakis","year":"2011","journal-title":"J Gastrointest Surg"},{"key":"2024121023185148000_ref8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jso.23943","article-title":"The indolent nature of pulmonary metastases from ductal adenocarcinoma of the pancreas","volume":"112","author":"Downs-Canner","year":"2015","journal-title":"J Surg Oncol"},{"key":"2024121023185148000_ref9","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.hpb.2018.12.002","article-title":"Isolated pulmonary recurrence after resection of pancreatic cancer: the effect of patient factors and treatment modalities on survival","volume":"21","author":"Groot","year":"2019","journal-title":"HPB"},{"key":"2024121023185148000_ref10","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/s00595-019-01794-w","article-title":"Surgical outcome of pulmonary metastasis from hepatopancreatobiliary carcinomas: a comparison with pulmonary metastasis from colorectal carcinomas","volume":"49","author":"Kaiho","year":"2019","journal-title":"Surg Today"},{"key":"2024121023185148000_ref11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00595-019-01902-w","article-title":"Initial pulmonary metastasis after pancreatectomy for pancreatic ductal adenocarcinoma","volume":"50","author":"Shimizu","year":"2020","journal-title":"Surg Today"},{"key":"2024121023185148000_ref12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s12893-021-01236-w","article-title":"Significance of pulmonary resection in patient with metachronous pulmonary metastasis from pancreatic ductal adenocarcinoma: a retrospective cohort study","volume":"21","author":"Mashiko","year":"2021","journal-title":"BMC Surg"},{"key":"2024121023185148000_ref13","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.surg.2023.05.008","article-title":"Pulmonary metastasectomy is associated with survival after lung-only recurrence in pancreatic cancer","volume":"174","author":"Stuart","year":"2023","journal-title":"Surgery"},{"key":"2024121023185148000_ref14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00423-023-03198-4","article-title":"Clinical benefits f pulmonary resection for lung metastases from pancreatic cancer","volume":"409","author":"Konishi","year":"2023","journal-title":"Langenbecks Arch Surg"},{"key":"2024121023185148000_ref15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2214\/AJR.16.17280","article-title":"Predictive CT features of visceral pleural invasion by T1-sized peripheral pulmonary adenocarcinomas manifesting as subsolid nodules","volume":"209","author":"Ahn","year":"2017","journal-title":"AJR"},{"key":"2024121023185148000_ref16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2214\/ajr.180.5.1801255","article-title":"Indeterminate solitary pulmonary nodules revealed at population-based CT screening of the lung: using first follow-up diagnostic CT to differentiate benign and malignant lesions","volume":"180","author":"Takashima","year":"2003","journal-title":"AJR"},{"key":"2024121023185148000_ref17","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1148\/radiographics.21.2.g01mr17403","article-title":"Atypical pulmonary metastases: spectrum of radiologic findings","volume":"21","author":"Seo","year":"2001","journal-title":"Radiographics"},{"key":"2024121023185148000_ref18","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"2024121023185148000_ref19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00004728-199603000-00025","article-title":"Air-space pattern in lung metastasis from adenocarcinoma of the GI tract","volume":"20","author":"Gaeta","year":"1996","journal-title":"J Cmput Assist Tomogr"},{"key":"2024121023185148000_ref20","first-page":"418","article-title":"High-resolution computed tomography appearances of surgically resected pulmonary metastases from colorectal cancer, with histopathologic correlation","volume":"23","author":"Kawaguchi","year":"2005","journal-title":"Radiat Med"},{"key":"2024121023185148000_ref21","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s003300000638","article-title":"Pulmonary metastases from pancreatic adenocarcinoma mimicking bronchoalveolar carcinoma","volume":"10","author":"Steinke","year":"2000","journal-title":"Eur Radiol"},{"key":"2024121023185148000_ref22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.compmedimag.2004.09.001","article-title":"Pulmonary metastasis from pancreatic cancer: a case showing biphasic radiological and histological patterns","volume":"28","author":"Okafuji","year":"2004","journal-title":"CMIG Extra: Cases"},{"key":"2024121023185148000_ref23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.diii.2020.11.015","article-title":"CT features of lung matastases from pancreatic adenocarcinoma: correlation with histopathologic findings","volume":"102","author":"Aissaoui","year":"2021","journal-title":"Dagn Interv Imaging"},{"key":"2024121023185148000_ref24","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s00595-023-02701-0","article-title":"Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer","volume":"53","author":"Miyashita","year":"2023","journal-title":"Surg Today"},{"key":"2024121023185148000_ref25","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s11748-020-01526-9","article-title":"Status of pleural lavage cytology in cases of pulmonary metastasis: a single-institution retrospective study","volume":"69","author":"Kawai","year":"2021","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"2024121023185148000_ref26","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/s10147-022-02131-x","article-title":"Integrative analysis identifies activated anti-tumor immune microenvironment in lung metastasis of pancreatic cancer","volume":"27","author":"Sasaki","year":"2022","journal-title":"Int J Clin Oncol"},{"key":"2024121023185148000_ref27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/54\/12\/1314\/60983209\/hyae107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/54\/12\/1314\/60983209\/hyae107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:19:44Z","timestamp":1733872784000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/54\/12\/1314\/7742923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,8,28]]},"published-print":{"date-parts":[[2024,12,7]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyae107","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,8,28]]}}}