{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:58:07Z","timestamp":1774684687104,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>There is no consensus on the optimal treatment for patients with locoregional recurrence of esophageal cancer after surgery. The objective of this study was to investigate the outcomes and prognostic factors associated with salvage radiotherapy in patients with locoregional recurrence of esophageal cancer after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We reviewed 80 patients with locoregional recurrence of esophageal cancer after surgery who were treated with radiotherapy. The median dose was 60\u00a0Gy, and 29 patients (36%) received elective nodal irradiation. Fifty-three patients (66%) received concurrent chemotherapy (mostly 5-fluorouracil and cisplatin) during radiotherapy. Overall survival, progression-free survival and in-field recurrence rate were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median follow-up period was 17\u00a0months. Two-year overall survival, progression-free survival and in-field recurrence rate were 50.3%, 23.5% and 41.3%, respectively. On multivariate analysis, a maximum diameter of locoregional recurrence lesions &amp;lt;30\u00a0mm was associated with higher overall survival (P\u00a0=\u00a00.044). Disease-free interval between surgery and locoregional recurrence &amp;gt;14\u00a0months was associated with higher PFS (P\u00a0=\u00a00.003). Late grade 3 toxicities occurred in three patients (3.8%). No grade 4 or higher toxicity was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Salvage radiotherapy demonstrated efficacy in achieving in-field control with acceptable toxicity. However, the high rate of out-of-field metastases led to poor progression-free survival and overall survival, particularly in cases involving large lesions and a short disease-free interval. A prospective study is warranted to establish a treatment strategy, particularly considering the combined use of effective anti-cancer drugs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyae124","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:42:48Z","timestamp":1725612168000},"page":"59-66","source":"Crossref","is-referenced-by-count":3,"title":["Salvage radiotherapy for locoregional recurrence of esophageal cancer after surgery"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-2974","authenticated-orcid":false,"given":"Akira","family":"Torii","sequence":"first","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4601-0119","authenticated-orcid":false,"given":"Natsuo","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-8923","authenticated-orcid":false,"given":"Taiki","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuhito","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya Ekisaikai Hospital , 4-66 Syonen-cho, Nakagawa-ku, Nagoya, Aichi 454-8502,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Japan Community Health care Organization Chukyo Hospital , 1-1-10 Sanjo, Minami-ku, Nagoya, Aichi 457-8510,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikao","family":"Sugie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital , 2-9 Myoken-cho, Showa-ku, Nagoya, Aichi 466-8650,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Nagoya City University East Medical Center , 1-2-23 Wakamizu, Chikusa-ku, Nagoya, Aichi 464-8547,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Miyakawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Hospital Organization Nagoya Medical Center , 4- 1-1, Sannomaru, Naka-ku, Nagoya, Aichi 460-0001,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ichinomiya Municipal Hospital , 2-2-22 Bunkyo, Ichinomiya, Aichi 491-8558,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kariya Toyota General Hospital , 5-15 Sumiyoshi-cho, Kariya, Aichi 448-8505,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Okazaki City Hospital , 3-1 Goshoai, Koryuji-cho, Okazaki, Aichi 444-8553,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kasugai Municipal Hospital , 1-1-1 Takaki-cho, Kasugai, Aichi 486-8510,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Takiguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Hiwatashi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 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