{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:16:40Z","timestamp":1789039000830,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Health Labor Sciences Research Grant from the Ministry of Health, Labor, and Welfare of Japan","award":["21EA1010"],"award-info":[{"award-number":["21EA1010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Single-center studies or randomized controlled trials have evaluated the impact of radiotherapy for bone metastases on quality of life (QOL). We investigated the real-world impact of radiotherapy for bone metastases on QOL using nationwide multicenter cohort data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective observational study at 26 centers in Japan. Of 333 patients who received radiotherapy for bone metastases between December 2020 and March 2021, 232 (70%) were enrolled in the study. Patient-reported QOL was evaluated at enrollment and at two- and six-month follow-up using the European Organization for Research and Treatment of Cancer (EORTC) QOL Questionnaire Core 15-Palliative and the EORTC QOL Questionnaire Bone Metastases module (QLQ-BM22). Possible predictors (patient-, tumor -, and treatment-related factors) of QOL improvement were screened using logistic regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>QOL scores showed significant improvement at two-month follow-up in seven (global health status\/QOL, emotional functioning, pain, insomnia, painful sites, pain characteristics and functional interference) of the 14 scales. Of these seven scales, mean improvement \u2265 the minimal clinically important difference (defined by a change of 10 or more on the 0 to 100 scale) was seen in four scales (pain, insomnia, pain characteristics and functional interference). We did not find any predictors of QOL improvement in the functional interference scale of QLQ-BM22.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Radiotherapy for bone metastases performed in daily practice is effective in improving some scales of QOL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyae150","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T09:31:26Z","timestamp":1730367086000},"page":"140-147","source":"Crossref","is-referenced-by-count":4,"title":["Quality of life improvement after radiotherapy for bone metastases assessed using real-world data: a secondary analysis of a Nationwide Multicenter Cohort Study"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3381-0766","authenticated-orcid":false,"given":"Nobuko","family":"Utsumi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology , Saitama Medical Center, , Saitama,","place":["Japan"]},{"name":"Saitama Medical University , Saitama Medical Center, , Saitama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Integrative Medical Oncology, Saiseikai Kumamoto Hospital , Kumamoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Shikama","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Juntendo University Graduate School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , Saitama Medical Center, , Saitama,","place":["Japan"]},{"name":"Saitama Medical University , Saitama Medical Center, , Saitama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Radiation Therapy, Shizuoka Cancer Center , Shizuoka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , St. Marianna University School of Medicine, Kanagawa,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , Saitama Medical Center, , Saitama,","place":["Japan"]},{"name":"Saitama Medical University , Saitama Medical Center, , Saitama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Notsu","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Shizuoka Cancer Center , Shizuoka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shirato","sequence":"additional","affiliation":[{"name":"Global Center for Biomedical Science and Engineering , Faculty of Medicine, , Hokkaido,","place":["Japan"]},{"name":"Hokkaido University , Faculty of Medicine, , Hokkaido,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Seirei Mikatahara General Hospital , Shizuoka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Uezono","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hyogo Cancer Center , Hyogo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8066-8753","authenticated-orcid":false,"given":"Yutaro","family":"Koide","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Aichi Cancer Center Hospital , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Kubota","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Kobe University Hospital , Hyogo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nagasaki University Hospital , Nagasaki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5792-3795","authenticated-orcid":false,"given":"Kei","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology , Department of Radiology, , Tokyo,","place":["Japan"]},{"name":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Department of Radiology, , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joichi","family":"Heianna","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanbu Tokushukai Hospital , Okinawa,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , St. Marianna University School of Medicine, Kanagawa,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Tonari","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kyorin University Hospital , Tokyo,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology , Faculty of Medicine, , Hokkaido,","place":["Japan"]},{"name":"Hokkaido University , Faculty of Medicine, , Hokkaido,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cancer Coordinate Clinic , Miyagi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ejima","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dokkyo Medical University , 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Yamanashi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobue","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kawasaki Municipal Ida Hospital , Kanagawa,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misako","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Sendai Kousei Hospital , Miyagi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-4429","authenticated-orcid":false,"given":"Miho","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University , Chiba,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayasu","family":"Nagakura","sequence":"additional","affiliation":[{"name":"Department of 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