{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:06:25Z","timestamp":1749182785391,"version":"3.41.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"the National Cancer Center Research and Development Fund","award":["26-A-4"],"award-info":[{"award-number":["26-A-4"]}]},{"DOI":"10.13039\/501100004330","name":"the Smoking Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The significance of station 4\u00a0L lymph node dissection (LND) for early-stage non-small cell lung cancer (NSCLC) is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We evaluated 342 patients who underwent complete anatomical resection and mediastinal LND for radiologically solid dominant clinical (c)-Stage I left upper lobe NSCLC between 2008 and 2022. Solid dominant was defined as a consolidation tumor ratio\u00a0&amp;gt;0.5, on thin-section computed tomography. After matching, postoperative complications and outcomes between the 4\u00a0L LND and non-4\u00a0L LND groups were compared. Predictors of 4\u00a0L metastasis was also identified using logistic regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>4LND was performed in 215 patients (63%), and 4\u00a0L metastasis was detected in 11 patients. Matching yielded 108 pairs. Recurrent nerve paralysis was more frequent in the 4LND group (P\u00a0=\u00a00.02) with no significant differences in the overall survival (OS) (5y OS: 85.2% vs. 86.3%, P\u00a0=\u00a00.66) and recurrence-free survival (RFS) (5y RFS: 78.4% vs. 78.5%, P\u00a0=\u00a00.51) between the 4\u00a0L LND and non-4\u00a0L LND groups. Logistic regression analysis determined solid component size &amp;gt;20\u00a0mm (P\u00a0=\u00a00.02) and pleural indentation (P\u00a0=\u00a00.02) on computed tomography findings as clinical risk factors for 4\u00a0L metastasis. The predictive criteria for 4\u00a0L metastasis were defined as solid component size \u226420\u00a0mm without pleural indentation (specificity: 100%, positive predictive value: 100%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>4\u00a0L LND had a higher frequency of recurrent nerve palsy, although no survival improvement was observed in solid dominant c-Stage I left upper NSCLC. 4\u00a0L LND may be omitted for solid component size \u226420\u00a0mm without pleural indentation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf032","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:16:17Z","timestamp":1740140177000},"page":"636-642","source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance of 4\u00a0L lymphadenectomy in solid dominant clinical stage I non-small cell lung cancer in the left upper lobe"],"prefix":"10.1093","volume":"55","author":[{"given":"Yukio","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of General Thoracic Surgery, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aritoshi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-345X","authenticated-orcid":false,"given":"Takeshi","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Takamochi","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"2025060506415721900_ref1","doi-asserted-by":"publisher","first-page":"iv1","DOI":"10.1093\/annonc\/mdx222","article-title":"Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and 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