{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:01:20Z","timestamp":1787655680732,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Center Research and Development Funds","award":["23-A-22"],"award-info":[{"award-number":["23-A-22"]}]},{"name":"National Cancer Center Research and Development Funds","award":["26-A-4"],"award-info":[{"award-number":["26-A-4"]}]},{"name":"National Cancer Center Research and Development Funds","award":["29-A-3"],"award-info":[{"award-number":["29-A-3"]}]},{"name":"National Cancer Center Research and Development Funds","award":["2020-J-3"],"award-info":[{"award-number":["2020-J-3"]}]},{"name":"National Cancer Center Research and Development Funds","award":["2023-J-03"],"award-info":[{"award-number":["2023-J-03"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP16ck0106350"],"award-info":[{"award-number":["JP16ck0106350"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Cancer Research"},{"name":"Ministry of Health, Labour, and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The JCOG1113, a multicenter, randomized phase III trial in patients with advanced\/recurrent biliary tract cancer showed the non-inferiority of gemcitabine plus S-1 to gemcitabine plus cisplatin. Although liver cirrhosis (LC) is a known risk factor for intrahepatic cholangiocarcinoma (ICC), few reports focus on the efficacy and safety of chemotherapy in ICC patients with LC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a subgroup analysis of ICC patients enrolled in the JCOG1113. The presence or absence of LC was evaluated based on clinical factors such as radiographic findings, medical history, laboratory data, and physical examination at enrollment. We evaluated differences in the safety and efficacy of chemotherapy according to the presence or absence of clinically diagnosed LC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 94 eligible patients with ICC, 10 were clinically diagnosed with LC. In the non-LC\/clinically diagnosed LC group, grade 3 or 4 neutropenia, anemia, decreased platelet count, and non-hematological adverse events were observed in 51.2%\/60%, 15.5%\/0%, 11.9%\/40%, and 38.1%\/30% patients. The median overall survival was 13.7\u00a0months in the non-LC group and 19.0\u00a0months in the clinically diagnosed LC group (hazard ratio [HR]: 0.969, 95% confidence interval [CI]: 0.482\u20131.948). The median progression-free survival was 5.9\u00a0months in the non-LC group and 7.1\u00a0months in the clinically diagnosed LC group (HR, 0.995; 95% CI, 0.513\u20131.929).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results of this study indicated that eligible ICC patients with clinically diagnosed LC, as determined by clinical and CT imaging findings, did not exhibit any apparent safety or efficacy disadvantage compared to those without LC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf035","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:47:53Z","timestamp":1741348073000},"page":"594-602","source":"Crossref","is-referenced-by-count":1,"title":["Impact of clinically diagnosed liver cirrhosis in patients with intrahepatic cholangiocarcinoma treated with systemic chemotherapy: a subgroup analysis of JCOG1113"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-483X","authenticated-orcid":false,"given":"Mao","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045,","place":["Japan"]},{"name":"Courses of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine , 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Chiba University , Chiba , 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-7503","authenticated-orcid":false,"given":"Chigusa","family":"Morizane","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gakuto","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7753-8712","authenticated-orcid":false,"given":"Yusuke","family":"Sano","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-0095","authenticated-orcid":false,"given":"Hiroshi","family":"Imaoka","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East , 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center , 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa 241-8515,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East , 6-5-1 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Nagaizumi-Cho, Sunto-Gun, Shizuoka 411-8777 ,","place":["Japan"]},{"name":"Department of Medical Oncology and Hematology, Oita University Faculty of Medicine , 1-1 Idaigaoka, Hasama-machi, Yufu-city, Oita 879-5593,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3716-6579","authenticated-orcid":false,"given":"Satoshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Saitama Cancer Center , 780 Komuro, Ina-machi, Kitaadati-gun, Saitama 362-0806 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-1885","authenticated-orcid":false,"given":"Nobumasa","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Aichi Cancer Center Hospital , 1-1 Kanokodono, Chikusa-ku, Nagoya 464-8681 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohei","family":"Satoi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kansai Medical University Hospital , 3-1 Shinmachi 2 Chome, Hirakata City, Osaka 573-1191 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Teikyo University School of Medicine , 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8606 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Tobimatsu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine , 7-5-1 Kusunoki-cho, Chuo-ku, Kobe City, Hyogo, 650-0017, 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