{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:05:57Z","timestamp":1774580757510,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to assess the prognostic outcomes and risk of adverse events in elderly non-muscle invasive bladder cancer (NMIBC) patients receiving photodynamic diagnosis-assisted transurethral resection of bladder cancer (PDD-TURBT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study retrospectively included 326 patients who were over 70\u00a0years old and received either PDD-TURBT (n\u00a0=\u00a0114, PDD group) or white-light TURBT (n\u00a0=\u00a0212, WL group). Oncological outcomes, namely recurrence-free survival (RFS) and progression-free survival (PFS), and adverse event profiles were compared between the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the PDD and WL groups, the median RFS periods were not reached and 41.7\u00a0months (P\u00a0&amp;lt;\u00a00.001), and the median PFS periods were not reached and 160.2\u00a0months (P\u00a0=\u00a00.057), respectively. The Grey test which take account to overall death as a competing risk event revealed recurrence tended to decrease in PDD group (P\u00a0=\u00a00.050). The independent prognostic factors were determined by multivariate Cox regression analyses: WL-TURBT in RFS. After propensity score matching, statistically favorable RFS in the PDD group were shown (P\u00a0=\u00a00.018). The incidence of AST\/ALT elevation and intraoperative hypotension (defined as systolic blood pressure\u00a0\u2264\u00a080\u00a0mmHg) were significantly higher in the PDD group than in the WL group (P\u00a0=\u00a00.003 and 0.003, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Prolonged RFS are expected for PDD-TURBT using oral 5-aminolevulinic acid in elderly NMIBC patients. However, the risks of liver injury and intraoperative hypotension are higher for PDD-TURBT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf047","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T15:45:26Z","timestamp":1741621526000},"page":"784-790","source":"Crossref","is-referenced-by-count":3,"title":["Comparing oncological outcomes and safety between photodynamic diagnosis-assisted and white-light transurethral resection in elderly patients with non-muscle invasive bladder cancer"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-9793","authenticated-orcid":false,"given":"Yuto","family":"Matsushita","sequence":"first","affiliation":[{"name":"Department of Urology, Hamamatsu University School of Medicine , 1-20-1 Handayama, Chuo-ku, Hamamatsu, Shizuoka 431-3192 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