{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:39:01Z","timestamp":1771043941962,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Sichuan Research Center for Applied Psychology, Chengdu Medical College","award":["CSXL-23408"],"award-info":[{"award-number":["CSXL-23408"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>In this prospective observational cohort study, we aim to investigate the risk factors for early postoperative anastomotic leakage (AL) in patients undergoing rectal cancer resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study included 459 patients with rectal cancer who underwent treatment at our hospital from January 2021 to October 2022. All patients were hospitalized for 1\u00a0week postoperatively and observed for the occurrence of AL. Fasting venous blood samples (5\u00a0mL) were collected from all cases 1\u00a0day before surgery and 1, 2, and 3\u00a0days after surgery, and serum levels of interleukins (IL)-17, IL-6, IL-1\u03b2, tumor necrosis factor-\u03b1, and C-reactive protein (CRP) were determined using enzyme-linked immunosorbent assay. Demographic, clinical data, intraoperative hypothermia, and nutritional indicators were collected for all patients. Statistical analysis was performed using SPSS 25.0 software.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>AL patients had significantly lower hemoglobin, albumin (ALB) levels, and a higher proportion of intraoperative hypothermia compared to patients in the non-AL group (P\u00a0&amp;lt;\u00a0.05). On the first, second, and third days after surgery, patients in the AL group had significantly higher levels of serum CRP, IL-1\u03b2, and IL-17 compared to the non-AL group. Pearson\u2019s correlation analysis showed a positive correlation between serum IL-17 levels and CRP levels. Serum IL-17 had the highest predictive value for early AL, with an area under the curve (AUC) of 0.755 cutoff value of 94.77\u00a0pg\/mL, a sensitivity of 70.1%, and a specificity of 66.0%. Moreover, logistic regression analysis indicated that intraoperative hypothermia, decreased ALB levels, and increased CRP, IL-1\u03b2, and IL-17 levels on the first day after surgery were identified as risk factors for early AL in rectal cancer patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study found a significant elevation of IL-17 levels in the serum of patients who experienced early postoperative AL. Furthermore, intraoperative hypothermia and elevated IL-17 levels on the first day after surgery were identified as risk factors for early postoperative AL in rectal cancer patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf053","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T08:00:17Z","timestamp":1744272017000},"page":"729-735","source":"Crossref","is-referenced-by-count":2,"title":["Elevated serum IL-17 levels and intraoperative hypothermia are risk factors for early postoperative anastomotic leakage in rectal cancer: a prospective observational study"],"prefix":"10.1093","volume":"55","author":[{"given":"Rong","family":"Qian","sequence":"first","affiliation":[{"name":"Operating Room, The Third People\u2019s Hospital of Chengdu , No. 82, Qinglong Street, Qingyang District, Chengdu, Sichuan 610014 ,","place":["P. R. 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