{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:55:00Z","timestamp":1770987300687,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Surgery is the standard of care for major salivary gland carcinoma (MSGC), and postoperative radiotherapy (PORT) is used for patients at high risk of postoperative recurrence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively analyzed 32 patients with MSGC treated with PORT between 2010 and 2019. All patients had one or more of the following high-risk factors for recurrence: histologically high-grade, T3\u20134 tumors, positive or close margins, lymph node (LN) metastasis, and perineural invasion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median age of the patients was 63\u00a0years (range, 18\u201381\u00a0years). Stage I, II, III, and IV disease were observed in 2, 5, 7, and 18 patients, respectively. Twenty-two patients underwent concurrent systemic therapy. The most commonly irradiated areas were the primary lesion and ipsilateral neck (78%). The 5-year overall survival (OS), recurrence-free survival (RFS) and locoregional control rates were 49%, 31%, and 77%, respectively. The 5-year OS rates were 86% for Stages I\u2013III, and 22% for Stage IV. The 5-year RFS rates were 57% for Stages I\u2013III, and 11% for Stage IV. Recurrence occurred in 22 patients. The most common pattern of recurrence was pulmonary metastases (34%). There were seven cases of cervical LN metastasis at the time of first recurrence, and five of these cases showed cervical LN metastases outside the irradiated area.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We reported the results of PORT in patients with MSGC. Although the incidence of in-field recurrence was low, recurrence from outside the irradiated area was common, suggesting the need for further investigation into the optimal systemic therapy and radiation extent.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf068","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T10:53:18Z","timestamp":1745837598000},"page":"751-757","source":"Crossref","is-referenced-by-count":1,"title":["Treatment outcomes and failure patterns in postoperative radiotherapy for major salivary gland carcinoma"],"prefix":"10.1093","volume":"55","author":[{"given":"Shota","family":"Miyoshi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Hiroshima City North Medical Center, Asa Citizens Hospital , 2-1-1 kabeminami, asakita-ku, Hiroshima 731-0293 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuno","family":"Nishibuchi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ochi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sakauchi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Katsuta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuki","family":"Imano","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 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