{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T18:19:21Z","timestamp":1757614761239,"version":"3.44.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study aimed to investigate the prognostic risk factors for T1\/2 major salivary gland cancer. Additionally, we sought to determine the impact of adjuvant radiotherapy, especially in low-grade cancer cases with clinicopathological adverse features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective review of medical records for 93 patients who underwent surgery for T1\/2 major salivary gland cancers between January 2000 and December 2024 was conducted. We evaluated clinicopathological adverse features as prognostic factors and compared 5-year disease-free survival (DFS) to determine the influence of adjuvant radiotherapy on prognosis in low-grade cancer cases exhibiting any histological adverse features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Lymphatic invasion was linked to reduced 5-year overall survival in patients with T1\/2 major salivary gland cancers (hazard ratio [HR]\u00a0=\u00a08.563, 95% confidence interval [CI]\u00a0=\u00a01.202\u201360.996, P\u00a0=\u00a0.032). Regarding 5-year DFS, histological grade and positive nodal metastasis were pinpointed as detrimental prognostic factors (HR\u00a0=\u00a03.330, 95% CI\u00a0=\u00a01.023\u201310.842, P\u00a0=\u00a0.046; HR\u00a0=\u00a09.891, 95% CI\u00a0=\u00a01.520\u201364.355, P\u00a0=\u00a0.046, respectively). For low-grade cancers presenting with any clinicopathological adverse features, no significant difference was observed in 5-year DFS following adjuvant radiotherapy (86.8% vs. 93.8%, P\u00a0=\u00a0.781).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Lymphatic invasion, high histological grade, and positive nodal metastasis were determined as poor prognostic factors in T1\/2 major salivary gland cancer. However, adjuvant radiotherapy did not significantly influence the prognosis in low-grade cancer cases with adverse features.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf089","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:50:57Z","timestamp":1747036257000},"page":"1022-1028","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic risk factors and clinical implications of adjuvant radiotherapy in T1\/2 major salivary gland cancer"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2525-5144","authenticated-orcid":false,"given":"Jooin","family":"Bang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , 1021, Tongil-ro, Eunpyeong-gu, Seoul 03312 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oh-Hyeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , 222, Banpo-daero, Seocho-gu, Seoul 06591,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geun-Jeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , 10 63-ro, Yeongdeungpo-gu, Seoul, 07345 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , 222, Banpo-daero, Seocho-gu, Seoul 06591,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Il","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea , 222, Banpo-daero, Seocho-gu, Seoul, 06591 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"2025090505420158200_ref1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.coms.2018.08.007","article-title":"Salivary gland malignancies","volume":"31","author":"Carlson","year":"2019","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"2025090505420158200_ref2","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.bjoms.2014.10.008","article-title":"Tumours of the salivary 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