{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T10:46:07Z","timestamp":1762685167494,"version":"build-2065373602"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Science and Technology Council in Taiwan","award":["111\u20132314-B-182A-044","112\u20132314-B-182A-128"],"award-info":[{"award-number":["111\u20132314-B-182A-044","112\u20132314-B-182A-128"]}]},{"name":"Chang Gung Memorial Hospital in Taiwan","award":["CMRPG3M1511\u00a0~\u00a02"],"award-info":[{"award-number":["CMRPG3M1511\u00a0~\u00a02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite the dosimetric advantages of intensity-modulated proton therapy (IMPT) in treating patients with nasopharyngeal carcinoma (NPC), it remains unclear whether these advantages confer improved health-related quality of life (HRQoL) compared to state-of-the-art photon-based techniques such as volumetric-modulated arc therapy (VMAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients with NPC eligible for definitive radiation therapy (RT) were invited to participate in the longitudinal observational study. Patient-reported outcomes were assessed using the Functional Assessment of Cancer Therapy\u2014Head &amp; Neck Cancer (FACT-HN) questionnaire at multiple time points: before, during, and after treatment. Propensity score matching (PSM) was utilized to align the IMPT group with the VMAT group. Longitudinal changes in HRQoL were then analyzed using generalized estimating equations (GEEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2008 to 2021, a total of 353 patients were enrolled in the study. After applying PSM at a 1:3 ratio, the final analysis included 213 patients in the VMAT group and 71 patients in the IMPT group. There were no significant differences were noted in the mean changes of FACT-HN scores from baseline between the IMPT and VMAT groups during treatment or throughout the follow-up periods as follows (IMPT vs. VMAT): \u221213.3 vs \u221214.4 (during RT), 2.2 vs. 1.0 (3\u00a0months post-RT), 5.4 vs. 8.5 (6\u00a0months post-RT), 10.8 vs. 10.1 (12\u00a0months post-RT), 10.2 vs. 10.5 (24\u00a0months post-RT), and 13.2 vs. 11.1 (36\u00a0months post-RT). Among all the subscales, only the emotional well-being (EWB) subscale demonstrated a significant difference at 36\u00a0months, favoring IMPT with scores of 2.7 versus 1.8 (p\u00a0=\u00a00.026). No significant differences were detected at other time points or within other subscales of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study found no clinically significant differences in overall HRQoL, as measured by the FACT-HN questionnaire, between IMPT and VMAT in the treatment of NPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf115","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:59:00Z","timestamp":1759406340000},"page":"1274-1281","source":"Crossref","is-referenced-by-count":0,"title":["Health-related quality of life changes in nasopharyngeal cancer patients: a propensity score-matched comparison of intensity-modulated proton therapy and volumetric-modulated arc therapy"],"prefix":"10.1093","volume":"55","author":[{"given":"Po-Jui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Keelung Chang Gung Memorial Hospital , Keelung ,","place":["Taiwan"]},{"name":"Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital , No. 222, Maijin Rd., Anle Dist., Keelung City 204 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Rong","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Nursing, College of Medicine, Chang Gung University , Taoyuan, 7th floor, Second Medical Building, 259 Wenhua 1st Road, Guishan District, Taoyuan City, 333 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Ping","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital , No. 222, Maijin Rd., Anle Dist., Keelung City 204 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Hsin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital , No. 222, Maijin Rd., Anle Dist., Keelung City 204 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Hung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Linkou Chang Gung Memorial Hospital , No. 5, Fuxing Street, Guishan District, Taoyuan City, 333 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiang-Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Linkou Chang Gung Memorial Hospital , No. 5, Fuxing Street, Guishan District, Taoyuan City, 333 ,","place":["Taiwan"]},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University , No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Jan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Linkou Chang Gung Memorial Hospital , No. 5, Fuxing Street, Guishan District, Taoyuan City, 333 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan-Jen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Linkou Chang Gung Memorial Hospital , No. 5, Fuxing Street, Guishan District, Taoyuan City, 333 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Linkou Chang Gung Memorial Hospital , No. 5, Fuxing Street, Guishan District, Taoyuan City, 333 ,","place":["Taiwan"]},{"name":"School of Medicine, College of Life Sciences and Medicine, National Tsing Hua University , No. 101, Section 2, Kuang-Fu Road, Hsinchu 300 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Linkou Chang Gung Memorial Hospital , No. 5, Fuxing Street, Guishan District, Taoyuan City, 333 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang-Hsu","family":"Lien","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Linkou Chang Gung Memorial Hospital , No. 5, Fuxing Street, Guishan District, Taoyuan City, 333 ,","place":["Taiwan"]},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University , No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333 ,","place":["Taiwan"]},{"name":"College of Medicine, Chang Gung University , No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 333, Taoyuan ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-0546","authenticated-orcid":false,"given":"Joseph Tung-Chieh","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital , No. 222, Maijin Rd., Anle Dist., Keelung City 204 ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"2025110905441299000_ref1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S1470-2045(15)70126-9","article-title":"Chemotherapy and radiotherapy in nasopharyngeal 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