{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:23:16Z","timestamp":1770992596183,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malignant phyllodes tumors (MPTs) are rare fibroepithelial breast tumors with no standard treatment for metastatic or recurrent cases. Comprehensive genomic profiling (CGP) has been conducted for MPT; however, its association with treatment remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted on patients with advanced or recurrent MPTs treated with chemotherapy between 2013 and 2022 at two hospitals, analyzing clinical data, CGP, treatment outcomes, and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five patients with metastatic MPTs who had received chemotherapy were identified. The median age was 55\u00a0years (range, 50\u201366), and all patients were female. As first-line treatment, four patients received doxorubicin plus ifosfamide (AI) combination therapy, while one received doxorubicin monotherapy. Among those treated with AI therapy, the best responses were partial response in three patients and stable disease in one. The median progression-free survival (PFS) for patients treated with AI therapy was 5.3\u00a0months. Of the five patients two proceeded to second-line therapy, and one patient received up to fourth-line treatment. Next-generation sequencing-based CGP testing was performed in four cases. One patient with an FGFR1-N546K-mutated MPT achieved a relatively long PFS of 6.8\u00a0months with pazopanib therapy, a multi-kinase inhibitor targeting FGFR1 among other kinases, as fourth-line therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AI therapy is useful for advanced or recurrent MPTs. The observed clinical benefit of pazopanib in a patient with FGFR1 N546K-mutated MPT suggests that FGFR1 kinase domain mutations may be a relevant factor in responsiveness of FGFR1-targeted therapy. Further data accumulation is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf169","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T01:20:36Z","timestamp":1762651236000},"page":"139-147","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes and genomic alterations in patients with metastatic malignant phyllodes tumors"],"prefix":"10.1093","volume":"56","author":[{"given":"Aya","family":"Takigawa","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Oncology, NHO Kyushu Medical Center , 1-8-1 Jigyohama, Chuo-ku, Fukuoka 810-8563 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-6382","authenticated-orcid":false,"given":"Kenji","family":"Tsuchihashi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Nio","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Oncology, Hamanomachi Hospital , 3-3-1 Nagahama, Chuo-ku, Fukuoka 810-8539 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Oncology, Hamanomachi Hospital , 3-3-1 Nagahama, Chuo-ku, Fukuoka 810-8539 ,","place":["Japan"]},{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Oncology, NHO Kyushu Medical Center , 1-8-1 Jigyohama, Chuo-ku, Fukuoka 810-8563 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Ohmura","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Comprehensive Oncology, Graduate School of Medical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Kuwayama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Oncology, NHO Kyushu Medical Center , 1-8-1 Jigyohama, Chuo-ku, Fukuoka 810-8563 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-5345","authenticated-orcid":false,"given":"Kyoko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Education, Faculty of Medical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9300-825X","authenticated-orcid":false,"given":"Mamoru","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotoe","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Gastrointestinal Oncology, Shizuoka Cancer Center , 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Oncology, NHO Kyushu Medical Center , 1-8-1 Jigyohama, Chuo-ku, Fukuoka 810-8563 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Isobe","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Oncology, Graduate School of Medical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Arita","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Oncology, Graduate School of Medical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 ,","place":["Japan"]},{"name":"Department of Medical Oncology and Internal Medicine , , 5-30 Kitatakamatu-cho, Miyazaki 880-8510 ,","place":["Japan"]},{"name":"Miyazaki Prefectural Miyazaki Hospital , , 5-30 Kitatakamatu-cho, Miyazaki 880-8510 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ariyama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Oncology, Kitakyushu Municipal Medical Center , 2-1-1 Bashaku, Kokurakita-ku, Kitakyushu 802-8561 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Kusaba","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 \u00a0","place":["Japan"]},{"name":"Department of Medical Oncology, Hamanomachi Hospital , 3-3-1 Nagahama, Chuo-ku, Fukuoka 810-8539 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-5723","authenticated-orcid":false,"given":"Koichi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eishi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Oncology, Graduate School of Medical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"2026021308522060500_ref1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4274\/ejbh.galenos.2023.2023-3-2","article-title":"Management and outcomes of metastatic and recurrent malignant phyllodes Tumors of the breast: a systematic literature review","volume":"19","author":"Samii","year":"2023","journal-title":"Eur J Breast Health"},{"key":"2026021308522060500_ref2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3233\/bd-140393","article-title":"Recurrent phyllodes tumor in the male breast in a background of gynaecomastia","volume":"35","author":"Chougule","year":"2015","journal-title":"Breast Dis"},{"key":"2026021308522060500_ref3","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1002\/1097-0142(19930515)71:10&lt;3020::AID-CNCR2820711022&gt;3.0.CO;2-G","article-title":"The descriptive epidemiology of malignant cystosarcoma phyllodes tumors of the breast","volume":"71","author":"Bernstein","year":"1993","journal-title":"Cancer."},{"key":"2026021308522060500_ref4","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1038\/sj.onc.1204621","article-title":"Relative frequency and morphology of cancers in carriers of germline TP53 mutations","volume":"20","author":"Birch","year":"2001","journal-title":"Oncogene."},{"key":"2026021308522060500_ref5","doi-asserted-by":"publisher","first-page":"665","DOI":"10.5858\/arpa.2016-0042-RA","article-title":"Phyllodes tumor of the breast: histopathologic features, differential diagnosis, and molecular\/genetic updates","volume":"140","author":"Zhang","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"2026021308522060500_ref6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/his.12876","article-title":"Phyllodes tumours of the breast: a consensus review","volume":"68","author":"Tan","year":"2016","journal-title":"Histopathology."},{"key":"2026021308522060500_ref7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.6004\/jnccn.2024.0035","article-title":"Breast cancer, version 3.2024, NCCN clinical practice guidelines in oncology","volume":"22","author":"Gradishar","year":"2024","journal-title":"J Natl Compr Canc Netw"},{"key":"2026021308522060500_ref8","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1002\/cncr.22228","article-title":"Malignant phyllodes tumor of the female breast: association of primary therapy with cause-specific survival from the surveillance, epidemiology, and end results (SEER) program","volume":"107","author":"Macdonald","year":"2006","journal-title":"Cancer."},{"key":"2026021308522060500_ref9","doi-asserted-by":"publisher","first-page":"106969","DOI":"10.1016\/j.ijsu.2022.106969","article-title":"Management of phyllodes tumor: a systematic review and meta-analysis of real-world evidence","volume":"107","author":"Yu","year":"2022","journal-title":"Int J Surg"},{"key":"2026021308522060500_ref10","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s10549-021-06116-8","article-title":"Outcomes of systemic therapy in metastatic phyllodes tumor of the breast","volume":"186","author":"Parkes","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"2026021308522060500_ref11","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00268-015-3262-7","article-title":"Treatment of patients with distant metastases from phyllodes tumor of the breast","volume":"40","author":"Mitu\u015b","year":"2016","journal-title":"World J Surg"},{"key":"2026021308522060500_ref12","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1245\/s10434-019-08097-x","article-title":"Impact of metastasis surgery and alkylating-agent-based chemotherapy on outcomes of metastatic malignant phyllodes Tumors: a Multicenter retrospective study","volume":"27","author":"Neron","year":"2020","journal-title":"Ann Surg Oncol"},{"key":"2026021308522060500_ref13","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/ng.3409","article-title":"Genomic landscapes of breast fibroepithelial tumors","volume":"47","author":"Tan","year":"2015","journal-title":"Nat Genet"},{"key":"2026021308522060500_ref14","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1158\/1541-7786.MCR-14-0578","article-title":"Next-gen sequencing exposes frequent MED12 mutations and actionable therapeutic targets in phyllodes Tumors","volume":"13","author":"Cani","year":"2015","journal-title":"Mol Cancer Res"},{"key":"2026021308522060500_ref15","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s10549-017-4156-1","article-title":"Comprehensive genomic profiling of malignant phyllodes tumors of the breast","volume":"162","author":"Nozad","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"2026021308522060500_ref16","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/nbt.2696","article-title":"Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing","volume":"31","author":"Frampton","year":"2013","journal-title":"Nat Biotechnol"},{"key":"2026021308522060500_ref17","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1111\/cas.13969","article-title":"Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: a hospital-based study","volume":"110","author":"Sunami","year":"2019","journal-title":"Cancer Sci"},{"key":"2026021308522060500_ref18","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"2026021308522060500_ref19","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10549-022-06524-4","article-title":"Systemic treatment in advanced phyllodes tumor of the breast: a multi-institutional European retrospective case-series analyses","volume":"192","author":"Palassini","year":"2022","journal-title":"Breast Cancer Res Treat"},{"key":"2026021308522060500_ref20","doi-asserted-by":"publisher","first-page":"2759650","DOI":"10.1155\/2019\/2759650","article-title":"Effective treatment of a malignant breast phyllodes tumor with doxorubicin-Ifosfamide therapy","volume":"2019","author":"Yamamoto","year":"2019","journal-title":"Case Rep Oncol Med"},{"key":"2026021308522060500_ref21","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/s40792-020-00986-8","article-title":"Malignant phyllodes tumor of the breast with rapid progression: a case report","volume":"6","author":"Abe","year":"2020","journal-title":"Surg Case Rep"},{"key":"2026021308522060500_ref22","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3919\/jjsa.83.649","article-title":"A case of metastastic malignant phyllodes tumor showing long-term disease control by eribulin and pazopanib","volume":"83","author":"Tayama","year":"2022","journal-title":"J Jpn Surg Assoc"},{"key":"2026021308522060500_ref23","volume-title":"Adverse events and Oncotargeted kinase inhibitors","author":"Tridente","year":"2017"},{"key":"2026021308522060500_ref24","doi-asserted-by":"publisher","first-page":"ra6","DOI":"10.1126\/scisignal.2000021","article-title":"The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations","volume":"2","author":"Lew","year":"2009","journal-title":"Sci Signal"},{"key":"2026021308522060500_ref25","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/modpathol.2016.97","article-title":"Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase\/RAS signaling pathways and provides insights into intratumoral heterogeneity","volume":"29","author":"Liu","year":"2016","journal-title":"Mod Pathol"},{"key":"2026021308522060500_ref26","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1038\/s41591-024-02934-7","article-title":"Pemigatinib in previously treated solid tumors with activating FGFR1-FGFR3 alterations: phase 2 FIGHT-207 basket trial","volume":"30","author":"Rod\u00f3n","year":"2024","journal-title":"Nat Med"},{"key":"2026021308522060500_ref27","doi-asserted-by":"publisher","first-page":"e2100371","DOI":"10.1200\/PO.21.00371","article-title":"Activity of Pemigatinib in pilocytic astrocytoma and FGFR1 N546K mutation","volume":"6","author":"Capone","year":"2022","journal-title":"JCO Precis Oncol"},{"key":"2026021308522060500_ref28","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.pathol.2022.03.008","article-title":"Analysis of recurrent molecular alterations in phyllodes tumour of breast: insights into prognosis and pathogenesis","volume":"54","author":"Tsang","year":"2022","journal-title":"Pathology."},{"key":"2026021308522060500_ref29","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1093\/oncolo\/oyae218","article-title":"Genomic landscape of malignant phyllodes tumors reveals multiple targetable opportunities","volume":"29","author":"Rosenberger","year":"2024","journal-title":"Oncologist."},{"key":"2026021308522060500_ref30","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1056\/NEJMoa2214131","article-title":"Capivasertib in hormone receptor-positive advanced breast cancer","volume":"388","author":"Turner","year":"2023","journal-title":"N Engl J Med"},{"key":"2026021308522060500_ref31","doi-asserted-by":"publisher","first-page":"1549452","DOI":"10.3389\/fimmu.2025.1549452","article-title":"Case report: efficacy of immune checkpoint inhibitors for high tumour mutational burden malignant phyllodes tumours of the breast as revealed by comprehensive genomic profiling","volume":"16","author":"Katsuya","year":"2025","journal-title":"Front Immunol"},{"key":"2026021308522060500_ref32","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"2026021308522060500_ref33","doi-asserted-by":"publisher","first-page":"l1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/56\/2\/139\/65224988\/hyaf169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/56\/2\/139\/65224988\/hyaf169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:52:29Z","timestamp":1770990749000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/56\/2\/139\/8315083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,11,5]]},"published-print":{"date-parts":[[2026,2,13]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyaf169","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2025,11,5]]}}}