{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:23:57Z","timestamp":1773419037798,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) are preventive options for women with hereditary breast and ovarian cancer (HBOC). The Japanese national medical insurance began covering RRM and RRSO for patients with HBOC in April 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 59 individuals with pathogenic germline variants (PGVs) from 55 families diagnosed with HBOC between 2010 and 2024 to assess the prevalence of RRM and RRSO after April 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age at diagnosis was 50\u00a0years. Ten individuals (16.9%) were diagnosed before April 2020, whereas 49 (83.1%) were diagnosed afterward. PGVs included BRCA1 (28 individuals) and BRCA2 (31 individuals). The most common cancer was breast cancer (74.6%), followed by ovarian (13.6%), and pancreatic cancer (3.3%); 15.3% had no cancer history. RRM was performed in 19 of 41 individuals (46.3%), with the highest rate observed among BRCA1 PGV individuals (55.0%). RRSO was conducted in 30 of 41 individuals (73.1%), with higher rates among BRCA1 and BRCA2 PGV individuals. None of the individuals without a history of breast and\/or ovarian cancer underwent these procedures. The median age was 50 for RRM and 49 for RRSO. Most surgeries (64.7% for RRM and 76.0% for RRSO) occurred within a year of genetic testing. Multivariate analysis showed that breast cancer history was strongly associated with RRM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>National insurance coverage has enhanced access to genetic testing and preventive surgeries, with 46.3% and 73.1% undergoing RRM and RRSO, respectively. However, individuals without a cancer history remain underrepresented.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf193","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:36:36Z","timestamp":1763645796000},"page":"317-323","source":"Crossref","is-referenced-by-count":0,"title":["Risk-reducing mastectomy and salpingo-oophorectomy in women with hereditary breast and ovarian cancer: a single-institute experience following coverage by Japanese national medical insurance"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-0648","authenticated-orcid":false,"given":"Akimitsu","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Oshi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Isa","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Koyasu","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mii","family":"Takatsuka","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kuriki","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Isoda","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahato","family":"Sasamoto","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Yokohama City University Medical Center , 4-57 Urafunecho, Minami-ward, Yokohama, Kanagawa 232-0024 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ogawara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Ishidera","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]},{"name":"Department of Obstetrics and Gynecology, Yokohama Municipal Citizen\u2019s Hospital , 1-1 Mitsuzawanisicho, Kanagawa-ward, Yokohama, Kanagawa 221-0855 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-4717","authenticated-orcid":false,"given":"Taichi","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Hamanoue","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Narui","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Yokohama City University Medical Center , 4-57 Urafunecho, Minami-ward, Yokohama, Kanagawa 232-0024 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]},{"name":"Department of Breast Surgery, Saiseikai Yokohamashi Nanbu Hospital , 3-2-10 Kounandai, Kounan-ward, Yokohama, Kanagawa 234-0054 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyasu","family":"Suganuma","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5492-0844","authenticated-orcid":false,"given":"Etsuko","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Breast Oncology, Tokyo Medical University hospital , 6-1-1 Sinjuku, Shinjuku-ward, Tokyo 160-8402 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3202-2752","authenticated-orcid":false,"given":"Itaru","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Yokohama City University Hospital , 3-9 Fukuura, Kanazawa-ward, Yokohama, Kanagawa 236-0004 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"2026031310021790600_ref1","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.1038\/s41467-018-06581-8","article-title":"Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls","volume":"9","author":"Momozawa","year":"2018","journal-title":"Nat Commun"},{"key":"2026031310021790600_ref2","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1245\/s10434-024-14893-x","article-title":"Society of Surgical Oncology breast disease site working group statement on contralateral mastectomy: Indications, outcomes, and risks","volume":"31","author":"Singh","year":"2024","journal-title":"Ann Surg Oncol"},{"key":"2026031310021790600_ref3","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA."},{"key":"2026031310021790600_ref4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S1470-2045(17)30891-4","article-title":"Germline BRCA mutation and outcome in young-onset breast cancer (POSH): A prospective cohort study","volume":"19","author":"Copson","year":"2018","journal-title":"Lancet Oncol"},{"key":"2026031310021790600_ref5","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1200\/JCO.22.00833","article-title":"BRCA-CRisk: A contralateral breast cancer risk prediction model for BRCA carriers","volume":"41","author":"Sun","year":"2023","journal-title":"J Clin Oncol"},{"key":"2026031310021790600_ref6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/sj.bjc.6602703","article-title":"Risk reduction of contralateral breast cancer and survival after contralateral prophylactic mastectomy in BRCA1 or BRCA2 mutation carriers","volume":"93","author":"Sprundel","year":"2005","journal-title":"Br J Cancer"},{"key":"2026031310021790600_ref7","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10549-013-2583-1","article-title":"Contralateral mastectomy improves survival in women with BRCA1\/2-associated breast cancer","volume":"140","author":"Evans","year":"2013","journal-title":"Breast Cancer Res Treat"},{"key":"2026031310021790600_ref8","doi-asserted-by":"publisher","first-page":"g226","DOI":"10.1136\/bmj.g226","article-title":"Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: Retrospective analysis","volume":"348","author":"Metcalfe","year":"2014","journal-title":"BMJ."},{"key":"2026031310021790600_ref9","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1002\/ijc.29032","article-title":"Improved overall survival after contralateral risk-reducing mastectomy in BRCA1\/2 mutation carriers with a history of unilateral breast cancer: A prospective analysis","volume":"136","author":"Heemskerk-Gerritsen","year":"2015","journal-title":"Int J Cancer"},{"key":"2026031310021790600_ref10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/0284186X.2017.1398415","article-title":"Clinical and molecular characterization of BRCA-associated breast cancer: Results from the DBCG","volume":"57","author":"Soenderstrup","year":"2018","journal-title":"Acta Oncol"},{"key":"2026031310021790600_ref11","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.1245\/s10434-020-08889-6","article-title":"Contralateral risk-reducing mastectomy in breast cancer patients who undergo multigene panel testing","volume":"27","author":"Murphy","year":"2020","journal-title":"Ann Surg Oncol"},{"key":"2026031310021790600_ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/1447545","article-title":"Contralateral prophylactic mastectomy among women with pathogenic variants in BRCA1\/2: Overall survival, racial, and ethnic differences","volume":"2022","author":"Makhnoon","year":"2022","journal-title":"Breast J"},{"key":"2026031310021790600_ref13","doi-asserted-by":"publisher","first-page":"Cd002748","DOI":"10.1002\/14651858.CD002748.pub4","article-title":"Risk-reducing mastectomy for the prevention of primary breast cancer","volume":"4","author":"Carbine","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"2026031310021790600_ref14","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.1245\/s10434-022-13056-0","article-title":"Survival outcomes in women with unilateral, triple-negative, breast cancer correlated with contralateral prophylactic mastectomy","volume":"30","author":"Fasano","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"2026031310021790600_ref15","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1093\/jjco\/hyac120","article-title":"Risk-reducing mastectomy for women with hereditary breast and ovarian cancer (HBOC): Analytical results of data from the Japanese organization of HBOC","volume":"52","author":"Ohsumi","year":"2022","journal-title":"Jpn J Clin Oncol"},{"key":"2026031310021790600_ref16","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s10549-014-3134-0","article-title":"Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRCA2 mutation carriers","volume":"148","author":"Chai","year":"2014","journal-title":"Breast Cancer Res Treat"},{"key":"2026031310021790600_ref17","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1158\/1055-9965.EPI-09-0171","article-title":"Uptake of risk-reducing surgery in unaffected women at high risk of breast and ovarian cancer is risk, age, and time dependent","volume":"18","author":"Evans","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2026031310021790600_ref18","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.maturitas.2013.10.017","article-title":"Risk-reducing mastectomy in BRCA1\/2 mutation carriers: Factors influencing uptake and timing","volume":"77","author":"Driel","year":"2014","journal-title":"Maturitas."},{"key":"2026031310021790600_ref19","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1200\/JCO.22.01239","article-title":"Contralateral breast cancer risk among carriers of germline pathogenic variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2","volume":"41","author":"Yadav","year":"2023","journal-title":"J Clin Oncol"},{"key":"2026031310021790600_ref20","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1038\/bjc.2011.120","article-title":"Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers","volume":"104","author":"Metcalfe","year":"2011","journal-title":"Br J Cancer"},{"key":"2026031310021790600_ref21","doi-asserted-by":"publisher","first-page":"5887","DOI":"10.1200\/JCO.2008.19.9430","article-title":"Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers","volume":"27","author":"Graeser","year":"2009","journal-title":"J Clin Oncol"},{"key":"2026031310021790600_ref22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13058-022-01567-3","article-title":"PredictCBC-2.0: A contralateral breast cancer risk prediction model developed and validated in ~\u2009200,000 patients","volume":"24","author":"Giardiello","year":"2022","journal-title":"Breast Cancer Res"},{"key":"2026031310021790600_ref23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12957-015-0638-y","article-title":"The Manchester guidelines for contralateral risk-reducing mastectomy","volume":"13","author":"Basu","year":"2015","journal-title":"World J Surg Oncol"},{"key":"2026031310021790600_ref24","doi-asserted-by":"publisher","first-page":"Cd012464","DOI":"10.1002\/14651858.CD012464.pub2","article-title":"Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations","volume":"8","author":"Eleje","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"2026031310021790600_ref25","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1200\/JCO.2007.13.9626","article-title":"Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: A multicenter, prospective study","volume":"26","author":"Kauff","year":"2008","journal-title":"J Clin Oncol"},{"key":"2026031310021790600_ref26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/jnci\/djn442","article-title":"Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers","volume":"101","author":"Rebbeck","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"2026031310021790600_ref27","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s10147-019-01456-4","article-title":"Clinical background and outcomes of risk-reducing salpingo-oophorectomy for hereditary breast and ovarian cancers in Japan","volume":"24","author":"Nomura","year":"2019","journal-title":"Int J Clin Oncol"},{"key":"2026031310021790600_ref28","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/jjco\/hyad020","article-title":"Risk-reducing salpingo-oophorectomy for Japanese women with hereditary breast and ovarian cancer: A single-institution 10-year experience","volume":"53","author":"Nagashima","year":"2023","journal-title":"Jpn J Clin Oncol"},{"key":"2026031310021790600_ref29","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.3349\/ymj.2021.62.12.1090","article-title":"Uptake rate of risk-reducing Salpingo-oophorectomy and surgical outcomes of female germline BRCA1\/2 mutation carriers: A retrospective cohort study","volume":"62","author":"Lim","year":"2021","journal-title":"Yonsei Med J"},{"key":"2026031310021790600_ref30","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s10689-017-0047-1","article-title":"Cancer risk management in Tasmanian women with BRCA1 and BRCA2 mutations","volume":"17","author":"Kearton","year":"2018","journal-title":"Fam Cancer"},{"key":"2026031310021790600_ref31","doi-asserted-by":"publisher","first-page":"647","DOI":"10.4048\/jbc.2020.23.e61","article-title":"Trends in risk-reducing mastectomy and risk-reducing Salpingo-oophorectomy in Korean carriers of the BRCA1\/2 mutation","volume":"23","author":"Jung","year":"2020","journal-title":"J Breast Cancer"},{"key":"2026031310021790600_ref32","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1056\/NEJMoa1913948","article-title":"Breast cancer risk genes - association analysis in more than 113,000 women","volume":"384","author":"Dorling","year":"2021","journal-title":"N Engl J Med"},{"key":"2026031310021790600_ref33","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1001\/jamaoncol.2023.6944","article-title":"MRI surveillance and breast cancer mortality in women with BRCA1 and BRCA2 sequence variations","volume":"10","author":"Lubinski","year":"2024","journal-title":"JAMA Oncol"},{"key":"2026031310021790600_ref34","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1007\/s10897-009-9245-9","article-title":"Women's decision making about risk-reducing strategies in the context of hereditary breast and ovarian cancer: A systematic review","volume":"18","author":"Howard","year":"2009","journal-title":"J Genet Couns"},{"key":"2026031310021790600_ref35","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1472-6874-10-24","article-title":"Women's constructions of the 'right time' to consider decisions about risk-reducing mastectomy and risk-reducing oophorectomy","volume":"10","author":"Howard","year":"2010","journal-title":"BMC Womens Health"},{"key":"2026031310021790600_ref36","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000503370","article-title":"Factors impacting on decision-making towards prophylactic surgeries in BRCA mutation carriers and women with familial predisposition","volume":"15","author":"Segerer","year":"2020","journal-title":"Breast Care (Basel)"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/56\/3\/317\/65739688\/hyaf193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jjco\/article-pdf\/56\/3\/317\/65739688\/hyaf193.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:02:25Z","timestamp":1773410545000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/56\/3\/317\/8365175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12,4]]},"published-print":{"date-parts":[[2026,3,13]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyaf193","relation":{},"ISSN":["1465-3621"],"issn-type":[{"value":"1465-3621","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,12,4]]}}}