{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:23:53Z","timestamp":1773419033699,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["24K18554"],"award-info":[{"award-number":["24K18554"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Olfactory neuroblastoma (ONB) is a rare malignant tumor of the nasal cavity and paranasal sinuses. In this study, we aimed to analyze ONB cases registered in the nationwide Head and Neck Cancer Registry of Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 90\u2009885 head and neck cancer registrations (2011\u201319), we identified 346 patients with ONB. We summarized demographics, tumor-node-metastasis (TNM) classification, and treatment modalities (surgery, radiotherapy, chemotherapy) and compared patterns between an early (2011\u201315) and a late (2016\u201319) period. Survival was analyzed in 95 patients with standardized 5-year outcomes available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>T4 lesions were frequent, and 234 patients (67.6%) received surgery-based treatment, typically combined with postoperative radiotherapy. Over time, endoscopic approaches increased markedly and became predominant over open skull base surgery. Among the 95 patients with evaluable follow-up, the 5-year overall survival (OS) and 5-year recurrence-free survival (RFS) were 85.1% and 62.7%, respectively. Patients &amp;lt;60\u00a0years old and female patients exhibited better OS compared to younger patients and males. Postoperative radiotherapy was associated with improved RFS but not OS. Chemotherapy was used more often with open skull base surgery than with other surgical approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Endoscopic surgery for ONB rose substantially, while younger age and female sex were associated with better OS, and postoperative radiotherapy was correlated with improved RFS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf204","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:07:59Z","timestamp":1765458479000},"page":"282-289","source":"Crossref","is-referenced-by-count":0,"title":["Nationwide analysis of olfactory neuroblastoma in Japan: evolving treatment approaches and prognostic outcomes"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-991X","authenticated-orcid":false,"given":"Mariko","family":"Sekimizu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine , 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Mikoshiba","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine , 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoto","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine , 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoaki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine , 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine , 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Kitayama","sequence":"additional","affiliation":[{"name":"Data Center Department, Clinical Study Support Center, Wakayama Medical University Hospital , 811-1 Kimiidera, Wakayama-shi, Wakayama 641-8510,","place":["Japan"]},{"name":"Japan Society for Head and Neck Cancer , 2-4-11 Fukagawa, Koto-ku, Tokyo 135-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-2790","authenticated-orcid":false,"given":"Daisuke","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Japan Society for Head and Neck Cancer , 2-4-11 Fukagawa, Koto-ku, Tokyo 135-0033, Japan"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences , 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Nibu","sequence":"additional","affiliation":[{"name":"Japan Society for Head and Neck Cancer , 2-4-11 Fukagawa, Koto-ku, Tokyo 135-0033, Japan"},{"name":"Department of Otolaryngology, Kobe University School of Medicine , 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-095X","authenticated-orcid":false,"given":"Seiichi","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Japan Society for Head and Neck Cancer , 2-4-11 Fukagawa, Koto-ku, Tokyo 135-0033, Japan"},{"name":"Department of Head and Neck Surgery, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine , 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"2026031310020547400_ref1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1001\/archotol.133.3.276","article-title":"Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors","volume":"133","author":"Jethanamest","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2026031310020547400_ref2","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1177\/1945892420973163","article-title":"Surgery as single-modality treatment for early-stage olfactory neuroblastoma: an institutional experience, systematic review and meta-analysis","volume":"35","author":"Meerwein","year":"2021","journal-title":"Am J Rhinol Allergy"},{"key":"2026031310020547400_ref3","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1001\/jamaoto.2023.1939","article-title":"Multicenter 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