{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:40:33Z","timestamp":1778035233623,"version":"3.51.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the palliative efficacy of re-irradiation stereotactic body radiotherapy (SBRT) for painful spinal metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-centre, single-arm, phase II study, patients with painful spinal metastases (pain score \u22652 on a 0\u201310 scale) from solid tumours were enrolled. Eligibility criteria included absence of epidural spinal cord compression, and irradiation history (excluding SBRT) with an interval of \u22653\u00a0months. The prescribed dose was 24\u00a0Gy in two fractions; the maximum spinal cord dose constraint was 12.2\u00a0Gy. The primary endpoint was the pain response rate at 6\u00a0months in evaluable patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 35 spinal lesions in 34 patients registered between July 2019 and June 2024, 11 (31%) lesions were severely painful (score, 8\u201310), 16 (46%) were radioresistant, and 14 (40%) involved \u22653 consecutive vertebrae. The median prior equivalent dose in 2-Gy fractions (\u03b1\/\u03b2\u00a0=\u00a010) was 33 (range, 23\u201370) Gy, and median interval between irradiations was 12 (range, 3\u2013114) months. The median follow-up period was 9 (range, 2\u201351) months. Among evaluable patients, pain response was 84% at 3\u00a0months and 83% at 6\u00a0months, whereas complete response (CR) was 48% and 56%, respectively. In the intention-to-treat analysis, pain response was 60% at 3\u00a0months and 43% at 6\u00a0months, whereas CR was 34% and 29%, respectively. The 6-month local failure rate was 7%. Two (6%) patients experienced grade 3 toxicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Re-irradiation SBRT achieved substantial pain relief with acceptable toxicity, warranting larger randomized trials against conventional radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyaf215","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:47:57Z","timestamp":1766494077000},"page":"428-434","source":"Crossref","is-referenced-by-count":1,"title":["Phase II trial of re-irradiation stereotactic body radiotherapy for painful spinal metastases"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4695-5227","authenticated-orcid":false,"given":"Kei","family":"Ito","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , 3-18-22 Honkomagome, Bunkyo, Tokyo 113-8677 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , 3-18-22 Honkomagome, Bunkyo, Tokyo 113-8677 ,","place":["Japan"]},{"name":"Department of Radiation Oncology, Miyagi Cancer Center , 47-1 Nodayama, Medeshima-Shiote, Natori-shi, Miyagi 981-1293 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , 3-18-22 Honkomagome, Bunkyo, Tokyo 113-8677 ,","place":["Japan"]},{"name":"Department of Radiological Sciences, Komazawa University , 1-23-1 Komazawa, Setagaya, Tokyo 154-8525 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , 3-18-22 Honkomagome, Bunkyo, Tokyo 113-8677 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhi","family":"Suda","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital , 3-18-22 Honkomagome, Bunkyo, Tokyo 113-8677 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko Nemoto","family":"Murofushi","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and 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