{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:28Z","timestamp":1792785988605,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["21\u00a0K17249"],"award-info":[{"award-number":["21\u00a0K17249"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["JP23K09549"],"award-info":[{"award-number":["JP23K09549"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research for Promotion of Cancer Control Programs from the Japanese Ministry of Health, Labour and Welfare","award":["23EA1031"],"award-info":[{"award-number":["23EA1031"]}],"id":[{"id":"https:\/\/ror.org\/03mwa7s65","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with schizophrenia spectrum disorders (SSD) experience higher cancer mortality, partly because of later-stage diagnosis and lower rates of recommended treatments. While treatment disparities have been reported across several cancer types, no study has specifically examined stage-appropriate treatment for gastric cancer among patients with SSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using a nationwide Hospital-Based Cancer Registry linked to administrative data in Japan. Patients who received initial treatment for gastric cancer between 2018 and 2021 were included. Multivariable logistic regression models examined the association between SSD and the receipt of stage-appropriate cancer treatments, adjusting for age, sex, clinical stage, Charlson Comorbidity Index, and Barthel Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 189\u2009447 patients from 709 hospitals, 1312 had SSD. Patients with SSD were more likely to be diagnosed at advanced stages. In crude analysis, SSD was associated with lower rates of surgical or endoscopic treatment; however, this association was not statistically significant after adjustment (adjusted odds ratio [aOR], 0.90; 95% confidence interval [CI], 0.75\u20131.08). In contrast, SSD was independently associated with lower rates of postoperative adjuvant chemotherapy for pathological stage II\/III disease (aOR, 0.64; 95% CI, 0.45\u20130.91) and systemic therapy for stage IV disease (aOR, 0.36; 95% CI, 0.28\u20130.47).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients with gastric cancer, SSD was associated with reduced receipt of systemic therapy but not surgical or endoscopic treatment. Efforts to improve early detection among patients with SSD may be important for reducing treatment disparities, alongside strengthened support for systemic therapy to ensure equitable access to guideline-recommended gastric cancer care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyag102","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:39:28Z","timestamp":1781613568000},"page":"1199-1206","source":"Crossref","is-referenced-by-count":0,"title":["Impact of pre-existing schizophrenia spectrum disorder on the receipt of invasive and systemic therapy for gastric cancer: a multicenter nationwide cohort study in Japan"],"prefix":"10.1093","volume":"56","author":[{"given":"Myo Min","family":"Khant","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Shimane University , 89-1 Enya-cho, Izumo 693-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-3166","authenticated-orcid":false,"given":"Masaki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Medical Development Field, Okayama University , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558 ,","place":["Japan"]},{"name":"Division of Survivorship Research, National Cancer Center Institute for Cancer Control, National Cancer Center , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Survivorship Research, National Cancer Center Institute for Cancer Control, National Cancer Center , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045,","place":["Japan"]},{"name":"Department of Neuropsychiatry Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558 ,","place":["Japan"]},{"name":"Department of Psychiatry, Sekizen Hospital , 140 ippo, Tsuyama 708-0883 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Division of Health Services Research, National Cancer Center Institute for Cancer Control, National Cancer Center , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomone","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Health Services Research, National Cancer Center Institute for Cancer Control, National Cancer Center , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 ,","place":["Japan"]},{"name":"Department of Public Health and Health Policy, Graduate School of Medicine, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fukao","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Medical Development Field, Okayama University , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-3390","authenticated-orcid":false,"given":"Maiko","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Division of Survivorship Research, National Cancer Center Institute for Cancer Control, National Cancer Center , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakaya","sequence":"additional","affiliation":[{"name":"Tohoku Medical Megabank Organization, Tohoku University , 2-1 Seiryo-machi, Aoba-ku, Sendai 980-0872 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Shimane University Hospital , 89-1 Enya-cho, Izumo 693-8501 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Shimane University , 89-1 Enya-cho, Izumo 693-8501,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Kakiuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine , 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6000-9830","authenticated-orcid":false,"given":"Taichi","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Division of Behavioral Sciences, National Cancer Center Institute for Cancer Control, National Cancer Center , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Hinotsu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Management, Sapporo Medical University , 17, Minami-1-jonishi, Chuo-ku, Sapporo 060-0061 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Uchitomi","sequence":"additional","affiliation":[{"name":"Department of Cancer Survivorship and Digital Medicine, The Jikei University School of Medicine , 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461 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