{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:58:07Z","timestamp":1785351487749,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Cancer Center Research and Development Funds","award":["2023-J-03"],"award-info":[{"award-number":["2023-J-03"]}]},{"name":"National Cancer Center Research and Development Funds","award":["2026-J-03"],"award-info":[{"award-number":["2026-J-03"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP26ck0106127h0001"],"award-info":[{"award-number":["JP26ck0106127h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Total laryngectomy with paratracheal dissection and elective lateral neck dissection (ELND) is the standard surgical procedure for T3\u2013T4aN0 laryngeal cancer. However, ELND is associated with increased surgical invasiveness, higher risk of postoperative complications, and long-term functional impairment. Although previous studies suggest that ELND omission may reduce postoperative complications, including pharyngocutaneous fistulas and deterioration in quality of life (QOL), its impact on prognosis remains controversial. Therefore, we designed a multicenter, randomized phase III trial (JCOG2407) to confirm the non-inferiority of total laryngectomy with paratracheal dissection alone compared to surgery including ELND for T3\u2013T4aN0 laryngeal cancer. The primary endpoint is overall survival. The secondary endpoints include short-term outcomes, postoperative complications, functional assessments, and QOL. A total of 280 patients from 39 institutions will be enrolled over 5\u00a0years. This trial has been registered with the Japan Registry of Clinical Trials (study number: jRCT1030250729).<\/jats:p>","DOI":"10.1093\/jjco\/hyag121","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:23:20Z","timestamp":1783941800000},"source":"Crossref","is-referenced-by-count":0,"title":["A multicenter randomized phase III trial to evaluate the value of omission of elective neck dissection for T3\u2013T4aN0 laryngeal cancer: JCOG2407 (JALNECK)"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5057-7985","authenticated-orcid":false,"given":"Kota","family":"Kawabata","sequence":"first","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office, National Cancer Center Hospital , 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Kita 15, Nishi 7, Kita-ku, Sapporo, Hokkaido 060-8638 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-8283","authenticated-orcid":false,"given":"Nobuhiro","family":"Hanai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Aichi Cancer Center Hospital , 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681 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Institute of Science Tokyo , 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, National Hospital Organization Shikoku Cancer Center , 160 Kou, Minamiumemoto-machi, Matsuyama, Ehime 791-0280 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Beppu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Aichi Cancer Center Hospital , 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mukaigawa","sequence":"additional","affiliation":[{"name":"Division of Head and Neck Surgery, Shizuoka Cancer Center , 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777 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