{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:04:42Z","timestamp":1790255082241,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K02459"],"award-info":[{"award-number":["JP24K02459"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26K23417"],"award-info":[{"award-number":["JP26K23417"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ama221325h0001"],"award-info":[{"award-number":["JP23ama221325h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project for Development of Innovative Cancer Medicine","award":["JP25ck0106001h0001"],"award-info":[{"award-number":["JP25ck0106001h0001"]}]},{"name":"Research Program for Hepatitis","award":["JP24fk0210158h0001"],"award-info":[{"award-number":["JP24fk0210158h0001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mitochondria have emerged as key determinants of cancer development and therapeutic response, extending their role beyond cellular energy production. Alterations in mitochondrial metabolism, mitochondrial DNA (mtDNA), dynamics, and quality control can support tumor growth and adaptation to the tumor microenvironment, while mitochondrial fitness also shapes the function and persistence of antitumor immune cells. Thus, mitochondrial biology represents a dynamic interface between tumor cells and the immune microenvironment. This review focuses on translating mitochondrial biology into clinical cancer applications in addition to recent advances in mitochondrial research. We evaluate mitochondrial alterations and mtDNA as diagnostic, prognostic, and predictive biomarkers, alongside strategies to selectively exploit cancer mitochondrial vulnerabilities while boosting antitumor immunity. We address key hurdles in therapeutic selectivity and discuss future perspectives for integrating mitochondrial targeting into precision oncology.<\/jats:p>","DOI":"10.1093\/jjco\/hyag160","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:08:02Z","timestamp":1788520082000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical perspectives on mitochondria in cancer"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7020-3065","authenticated-orcid":false,"given":"Hiroko","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Tumor Microenvironment, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University , 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-0164","authenticated-orcid":false,"given":"Yosuke","family":"Togashi","sequence":"additional","affiliation":[{"name":"Department of Tumor Microenvironment, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University , 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Department of Respiratory Medicine, Okayama University Hospital , 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558,","place":["Japan"]},{"name":"Faculty of Medicine, Kindai University , 1-14-1 Mihara-dai, Minami-ku, Sakai, Osaka, 590-0197 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"2026092408285405500_ref1","first-page":"319","article-title":"\u00dcber den Stoffwechsel der 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