{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:59:03Z","timestamp":1790859543490,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malignant soft tissue sarcomas (STSs) are rare, aggressive tumors with diverse subtypes and variable prognoses. Current prognostic markers, such as tumor size and grade, do not sufficiently predict postoperative outcomes. Therefore, this study aimed to assess the prognostic significance of the hemoglobin, albumin, lymphocyte, platelet (HALP) score, an integrated immunonutritional marker, for predicting overall survival (OS) in patients with extremity and trunk STSs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 99 patients with primary STS who underwent wide excision. The primary endpoint was OS. Systemic inflammatory and nutritional indices, including HALP, were evaluated using pre-treatment blood samples. OS was analysed using Kaplan\u2013Meier curves and Cox proportional hazards models. Receiver operating characteristic curve analysis was used to determine the prognostic value of the HALP score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-nine deaths occurred during a median follow-up of 83.6\u00a0months. Three- and five-year OS were 82.1% and 74.2%, respectively. Lower HALP was associated with worse OS (hazard ratio 3.89, 95% confidence interval 1.66\u20139.13; P\u00a0=\u00a00.002). In multivariable analysis, a low HALP score (\u226439.4) remained independently associated with worse OS (hazard ratio 3.17, 95% confidence interval 1.33\u20137.54; P\u00a0=\u00a00.011). The 5-year time-dependent AUC for HALP was 0.763, which was numerically higher than those of the other inflammatory and nutritional indices; however, the differences were not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The HALP score stratified patients with STS by risk of adverse postoperative outcomes and may serve as a practical and accessible exploratory prognostic marker. Prospective validation is required before HALP can be incorporated into prognostic models or used to guide treatment decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jjco\/hyag171","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:12:06Z","timestamp":1790334726000},"source":"Crossref","is-referenced-by-count":0,"title":["HALP is a novel marker for predicting overall survival in patients with malignant soft tissue sarcoma: a retrospective study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-989X","authenticated-orcid":false,"given":"Seiji","family":"Shimomura","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryu","family":"Terauchi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Mizoshiri","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusei","family":"Katsuyama","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026100108330814300_ref1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"2026100108330814300_ref2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3322\/caac.21605","article-title":"Soft-tissue sarcoma in adults: an update on the current state of histiotype-specific management in an era of personalized medicine","volume":"70","author":"Gamboa","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"2026100108330814300_ref3","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.ejso.2016.03.026","article-title":"The width of resection margins 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carcinoma","volume":"10","author":"Zhang","year":"2017","journal-title":"Onco Targets Ther"},{"key":"2026100108330814300_ref7","first-page":"12231","article-title":"Impact of systemic inflammation on survival in patients with metastatic soft tissue sarcoma","volume":"37","author":"Salmiheimo","year":"2016","journal-title":"Tumor Biol"},{"key":"2026100108330814300_ref8","first-page":"695","article-title":"The neutrophil-to-lymphocyte ratio as a prognostic marker for survival in soft-tissue sarcoma patients","volume":"22","author":"Takano","year":"2020","journal-title":"Clin Transl Oncol"},{"key":"2026100108330814300_ref9","first-page":"1124","article-title":"Sarcopenia is associated with poor prognosis in patients with retroperitoneal sarcoma","volume":"218","author":"Gaitanidis","year":"2019","journal-title":"Am J Surg"},{"key":"2026100108330814300_ref10","first-page":"963","article-title":"Preoperative anemia is associated with poor prognosis in patients with retroperitoneal sarcoma","volume":"123","author":"Schuettfort","year":"2021","journal-title":"J Surg Oncol"},{"key":"2026100108330814300_ref11","first-page":"1488","article-title":"C-reactive protein\/albumin ratio as a predictor of survival in patients with resectable soft tissue sarcoma","volume":"40","author":"Choi","year":"2014","journal-title":"Eur J Surg Oncol"},{"key":"2026100108330814300_ref12","first-page":"4938651","article-title":"Prognostic impact of sarcopenia on overall survival in patients with primary sarcoma of the bone or soft tissue","volume":"2022","author":"Romano","year":"2022","journal-title":"Sarcoma"},{"key":"2026100108330814300_ref13","first-page":"2589","article-title":"Preoperative HALP score and its role in survival outcomes after resection of retroperitoneal sarcomas: a multi-institutional analysis","volume":"30","author":"Farag","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"2026100108330814300_ref14","first-page":"144","article-title":"Prognostic significance of HALP (hemoglobin, albumin, lymphocyte, and platelet) score in gastric carcinoma: a retrospective study","volume":"15","author":"Chen","year":"2015","journal-title":"BMC Cancer"},{"key":"2026100108330814300_ref15","first-page":"345","article-title":"The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is associated with prognosis in colorectal cancer patients","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Cancer"},{"key":"2026100108330814300_ref16","first-page":"245","article-title":"Prognostic value of the HALP score in patients undergoing surgery for retroperitoneal sarcoma: a retrospective study","volume":"8","author":"Jiang","year":"2016","journal-title":"Cancer Manag Res"},{"key":"2026100108330814300_ref17","first-page":"1547","article-title":"Prognostic value of inflammatory and nutritional parameters in patients with malignant soft tissue sarcomas","volume":"13","author":"Matsui","year":"2022","journal-title":"J 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