{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:39:41Z","timestamp":1768808381902,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"DOI":"10.1093\/jjco\/hyw002","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T19:39:03Z","timestamp":1463859543000},"page":"427-434","source":"Crossref","is-referenced-by-count":29,"title":["5-Hydroxymethylcytosine expression is associated with poor survival in cervical squamous cell carcinoma"],"prefix":"10.1093","volume":"46","author":[{"given":"Li-Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Second Affiliated Hospital of Harbin Medical University, Harbin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Song","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harbin Medical University, Harbin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Second Affiliated Hospital of Harbin Medical University, Harbin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"key\n\t\t\t\t2018110810575358900_HYW002C1","first-page":"231","article-title":"Prevalence, characteristics, and outcomes of HIV-positive women diagnosed with invasive cancer of the cervix in Kenya","volume":"123","author":"Chemtai","year":"2013","journal-title":"Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C2","first-page":"339","article-title":"Lack of association between herpes simplex virus type 2 infection and cervical cancer-Taq Man realtime PCR assay findings","volume":"13","author":"Farivar","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C3","first-page":"221","article-title":"Promoters of and barriers to cervical cancer screening in a rural setting in Tanzania","volume":"123","author":"Perng","year":"2013","journal-title":"Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C4","first-page":"96","article-title":"Regulation of microRNAs by epigenetics and their interplay involved in cancer","volume":"32","author":"Liu","year":"2013","journal-title":"J Exp Clin Cancer Res"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C5","first-page":"930","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C6","first-page":"e15367","article-title":"Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates","volume":"5","author":"Globisch","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C7","first-page":"68","article-title":"Selective chemical labeling reveals the genome wide distribution of 5-hydroxymethylcytosine","volume":"29","author":"Song","year":"2011","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C8","first-page":"1129","article-title":"Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification","volume":"466","author":"Ito","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C9","first-page":"1135","article-title":"Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma","volume":"150","author":"Lian","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C10","first-page":"e41036","article-title":"Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma","volume":"7","author":"Orr","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C11","first-page":"670","article-title":"Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation","volume":"103","author":"Kudo","year":"2012","journal-title":"Cancer Sci"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C12","first-page":"663","article-title":"Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation","volume":"32","author":"Yang","year":"2013","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C13","first-page":"1300","article-title":"Tet proteins can convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C14","first-page":"1303","article-title":"Tet-mediated formation of 5-Carboxylcytosine and its excision by TDG in mammalian DNA","volume":"333","author":"He","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C15","first-page":"1895","article-title":"Tet family proteins and 5-hydroxymethylcytosine in development and disease","volume":"139","author":"Tan","year":"2012","journal-title":"Development"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C16","first-page":"103","article-title":"Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium","volume":"105","author":"Pecorelli","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C17","first-page":"1148","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C18","first-page":"1698","article-title":"Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids","volume":"8","author":"Iyer","year":"2009","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C19","first-page":"627","article-title":"Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem\/progenitor cell compartments and in human cancers","volume":"2","author":"Haffner","year":"2011","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C20","first-page":"451","article-title":"Genome-wide regulation of 5 hmC, 5 mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells","volume":"42","author":"Xu","year":"2011","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C21","first-page":"17","article-title":"Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases","volume":"19","author":"Xu","year":"2011","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C22","first-page":"553","article-title":"Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation","volume":"18","author":"Figueroa","year":"2010","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C23","first-page":"510","article-title":"Cancer Genome Atlas Research Network: Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma","volume":"17","author":"Noushmehr","year":"2010","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t2018110810575358900_HYW002C24","first-page":"e62828","article-title":"Decrease of 5-Hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1","volume":"8","author":"Liu","year":"2013","journal-title":"Plos One"}],"container-title":["Japanese Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jjco\/article-pdf\/46\/5\/427\/26444489\/hyw002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T10:58:04Z","timestamp":1541674684000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jjco\/article\/46\/5\/427\/2218808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,1]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,19]]},"published-print":{"date-parts":[[2016,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jjco\/hyw002","relation":{},"ISSN":["1465-3621","0368-2811"],"issn-type":[{"value":"1465-3621","type":"electronic"},{"value":"0368-2811","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,5]]},"published":{"date-parts":[[2016,5,1]]}}}